eF-site ID 4eop-C
PDB Code 4eop
Chain C

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Title Thr 160 phosphorylated CDK2 Q131E - human cyclin A3 complex with the inhibitor RO3306
Classification TRANSFERASE/TRANSFERASE INHIBITOR
Compound Cyclin-dependent kinase 2
Source Homo sapiens (Human) (CCNA2_HUMAN)
Sequence C:  SMENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDT
ETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLV
FEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCH
SHRVLHRDLKPENLLINTEGAIKLADFGLARAFGVPVRTY
XHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTR
RALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPS
FPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKA
ALAHPFFQDVTKPVPHL
Description (1)  Cyclin-dependent kinase 2 (E.C.2.7.11.22), Cyclin-A2


Functional site

1) chain C
residue 10
type
sequence I
description BINDING SITE FOR RESIDUE 1RO C 301
source : AC3

2) chain C
residue 12
type
sequence E
description BINDING SITE FOR RESIDUE 1RO C 301
source : AC3

3) chain C
residue 13
type
sequence G
description BINDING SITE FOR RESIDUE 1RO C 301
source : AC3

4) chain C
residue 31
type
sequence A
description BINDING SITE FOR RESIDUE 1RO C 301
source : AC3

5) chain C
residue 81
type
sequence E
description BINDING SITE FOR RESIDUE 1RO C 301
source : AC3

6) chain C
residue 82
type
sequence F
description BINDING SITE FOR RESIDUE 1RO C 301
source : AC3

7) chain C
residue 83
type
sequence L
description BINDING SITE FOR RESIDUE 1RO C 301
source : AC3

8) chain C
residue 86
type
sequence D
description BINDING SITE FOR RESIDUE 1RO C 301
source : AC3

9) chain C
residue 131
type
sequence E
description BINDING SITE FOR RESIDUE 1RO C 301
source : AC3

10) chain C
residue 132
type
sequence N
description BINDING SITE FOR RESIDUE 1RO C 301
source : AC3

11) chain C
residue 134
type
sequence L
description BINDING SITE FOR RESIDUE 1RO C 301
source : AC3

12) chain C
residue 145
type
sequence D
description BINDING SITE FOR RESIDUE 1RO C 301
source : AC3

13) chain C
residue 14
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507
source Swiss-Prot : SWS_FT_FI7

14) chain C
residue 19
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0007744|PubMed:19369195
source Swiss-Prot : SWS_FT_FI9

15) chain C
residue 127
type ACT_SITE
sequence D
description Proton acceptor
source Swiss-Prot : SWS_FT_FI1

16) chain C
residue 160
type MOD_RES
sequence X
description Phosphothreonine; by CAK and CCRK => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:14597612, ECO:0000269|PubMed:16325401, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:17570665, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:21565702, ECO:0000305|PubMed:28666995
source Swiss-Prot : SWS_FT_FI10

17) chain C
residue 129
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

18) chain C
residue 10
type BINDING
sequence I
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

19) chain C
residue 33
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

20) chain C
residue 81
type BINDING
sequence E
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

21) chain C
residue 86
type BINDING
sequence D
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI2

22) chain C
residue 132
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI3

23) chain C
residue 145
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:21565702
source Swiss-Prot : SWS_FT_FI3

24) chain C
residue 9
type SITE
sequence K
description CDK7 binding
source Swiss-Prot : SWS_FT_FI4

25) chain C
residue 88
type SITE
sequence K
description CDK7 binding
source Swiss-Prot : SWS_FT_FI4

26) chain C
residue 166
type SITE
sequence L
description CDK7 binding
source Swiss-Prot : SWS_FT_FI4

27) chain C
residue 1
type MOD_RES
sequence M
description N-acetylmethionine => ECO:0007744|PubMed:22814378
source Swiss-Prot : SWS_FT_FI5

28) chain C
residue 6
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI6

29) chain C
residue 15
type MOD_RES
sequence Y
description Phosphotyrosine; by WEE1 => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507, ECO:0007744|PubMed:19690332
source Swiss-Prot : SWS_FT_FI8


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