|
|
eF-site ID
|
4eok-B |
|
PDB Code
|
4eok |
|
Chain
|
B |
|
click to enlarge
|
|
|
Title
|
Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102 |
|
Classification
|
Transferase/Transferase Inhibitor |
|
Compound
|
Cyclin-dependent kinase 2 |
|
Source
|
Homo sapiens (Human) (CCNA2_HUMAN) |
|
|
Sequence
|
B: |
VPDYHEDIHTYLREMEVKCKPKVGYMKKQPDITNSMRAIL
VDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQ
LVGTAAMLLASKFEEIYPPEVAEFVYITDDTYTKKQVLRM
EHLVLKVLTFDLAAPTVNQFLTQYFLHQQPANCKVESLAM
FLGELSLIDADPYLKYLPSVIAGAAFHLALYTVTGQSWPE
SLIRKTGYTLESLKPCLMDLHQTYLKAPQHAQQSIREKYK
NSKYHGVSLLNPPETLNL
|
|
|
Description
|
(1) |
Cyclin-dependent kinase 2 (E.C.2.7.11.22), Cyclin-A2
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
189 |
| type |
|
| sequence |
M
|
| description |
BINDING SITE FOR RESIDUE SGM B 501
|
| source |
: AC2
|
|
|
2)
|
chain |
B |
| residue |
193 |
| type |
|
| sequence |
C
|
| description |
BINDING SITE FOR RESIDUE SGM B 501
|
| source |
: AC2
|
|
|
3)
|
chain |
B |
| residue |
211-242 |
| type |
prosite |
| sequence |
RAILVDWLVEVGEEYKLQNETLHLAVNYIDRF
|
| description |
CYCLINS Cyclins signature. RaiLvdWLvevgeeykLqnetLhlAVnYIDRF
|
| source |
prosite : PS00292
|
|
|
|