eF-site ID 4eo4-ABCD PDB Code 4eo4 Chain A, B, C, D click to enlarge Title Crystal structure of the yeast mitochondrial threonyl-tRNA synthetase (MST1) in complex with seryl sulfamoyl adenylate Classification LIGASE Compound Threonine--tRNA ligase, mitochondrial Source Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (SYTM_YEAST) Sequence A:  ATMTSMVSQRQDLFMTDPLSPGSMFFLPNGAKIFNKLIEF MKLQQKFKFGFNEVVTPLIYKKTLWEKSGHWENYADDMFK VETKEEYGLKPMNCPGHCLIFGKKDRSYNELPLRFSDFSP LHRNEASGALSGLTRLRKFHQDDGHIFCTPSQVKSEIFNS LKLIDIVYNKIFPFAESNYFINFSTRPDHFIGDLKVWNHA EQVLKEILEESGKPWKLNPGDGAFYGPKLDIMVTDHLRKT HQVATIQLDFQLPERFDLKFKDQDNSYKRPIMIHRATFGS IERFMALLIDSNEGRWPFWLNPYQAVIIPVNTKNVQQLDM CTALQKKLRNELEADDMEPVPLNDWHFNVDLDIRNEPVGY RIKSAILKNYSYLIIVGDEEVQLQKYNIRERDNRKSFEKL TMSQIWEKFIELEKNYK B:  MTSMVSQRQDLFMTDPLSPGSMFFLPNGAKIFNKLIEFMK LQQKFKFGFNEVVTPLIYKKTLWEKSGHWENYADDMFKVE TKEEYGLKPMNCPGHCLIFGKKDRSYNELPLRFSDFSPLH RNEASGALSGLTRLRKFHQDDGHIFCTPSQVKSEIFNSLK LIDIVYNKIFPFSNYFINFSTRPDHFIGDLKVWNHAEQVL KEILEESGKPWKLNPGDGAFYGPKLDIMVTDHLRKTHQVA TIQLDFQLPERFDLKFKDQDNSYKRPIMIHRATFGSIERF MALLIDSNEGRWPFWLNPYQAVIIPVNTKNVQQLDMCTAL QKKLRNELEADDMEPVPLNDWHFNVDLDIRNEPVGYRIKS AILKNYSYLIIVGDEEVQLQKYNIRERDNRKSFEKLTMSQ IWEKFIELEKNYK C:  ATMTSMVSQRQDLFMTDPLSPGSMFFLPNGAKIFNKLIEF MKLQQKFKFGFNEVVTPLIYKKTLWEKSGHWENYADDMFK VETTEKEEYGLKPMNCPGHCLIFGKKDRSYNELPLRFSDF SPLHRNEASGALSGLTRLRKFHQDDGHIFCTPSQVKSEIF NSLKLIDIVYNKIFPSNYFINFSTRPDHFIGDLKVWNHAE QVLKEILEESGKPWKLNPGDGAFYGPKLDIMVTDHLRKTH QVATIQLDFQLPERFDLKFKDQDNSYKRPIMIHRATFGSI ERFMALLIDSNEGRWPFWLNPYQAVIIPVNTKNVQQLDMC TALQKKLRNELEADDMEPVPLNDWHFNVDLDIRNEPVGYR IKSAILKNYSYLIIVGDEEVQLQKYNIRERDNRKSFEKLT MSQIWEKFIELEKNYK D:  ATMTSMVSQRQDLFMTDPLSPGSMFFLPNGAKIFNKLIEF MKLQQKFKFGFNEVVTPLIYKKTLWEKSGHWENYADDMFK VETKEEYGLKPMNCPGHCLIFGKKDRSYNELPLRFSDFSP LHRNEASGALSGLTRLRKFHQDDGHIFCTPSQVKSEIFNS LKLIDIVYNKIFPSNYFINFSTRPDHFIGDLKVWNHAEQV LKEILEESGKPWKLNPGDGAFYGPKLDIMVTDHLRKTHQV ATIQLDFQLPERFDLKFKDQDNSYKRPIMIHRATFGSIER FMALLIDSNEGRWPFWLNPYQAVIIPVNTKNVQQLDMCTA LQKKLRNELEADDMEPVPLNDWHFNVDLDIRNEPVGYRIK SAILKNYSYLIIVGDEEVQLQKYNIRERDNRKSFEKLTMS QIWEKFIELEKNYK Description Functional site 1) chain A residue 131 type sequence M description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 2) chain A residue 162 type sequence R description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 3) chain A residue 164 type sequence E description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 4) chain A residue 173 type sequence T description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 5) chain A residue 174 type sequence R description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 6) chain A residue 175 type sequence L description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 7) chain A residue 178 type sequence F description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 8) chain A residue 180 type sequence Q description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 9) chain A residue 182 type sequence D description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 10) chain A residue 287 type sequence Q description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 11) chain A residue 288 type sequence V description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 12) chain A residue 292 type sequence Q description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 13) chain A residue 319 type sequence H description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 14) chain A residue 324 type sequence G description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 15) chain A residue 325 type sequence S description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 16) chain A residue 328 type sequence R description BINDING SITE FOR RESIDUE SSA A 1001 source : AC1 17) chain A residue 403 type sequence V description BINDING SITE FOR RESIDUE SSA A 1002 source : AC2 18) chain A residue 404 type sequence G description BINDING SITE FOR RESIDUE SSA A 1002 source : AC2 19) chain A residue 407 type sequence I description BINDING SITE FOR RESIDUE SSA A 1002 source : AC2 20) chain A residue 408 type sequence K description BINDING SITE FOR RESIDUE SSA A 1002 source : AC2 21) chain A residue 411 type sequence I description BINDING SITE FOR RESIDUE SSA A 1002 source : AC2 22) chain A residue 434 type sequence R description BINDING SITE FOR RESIDUE SSA A 1002 source : AC2 23) chain A residue 439 type sequence R description BINDING SITE FOR RESIDUE SSA A 1002 source : AC2 24) chain A residue 133 type sequence C description BINDING SITE FOR RESIDUE ZN A 1003 source : AC3 25) chain A residue 184 type sequence H description BINDING SITE FOR RESIDUE ZN A 1003 source : AC3 26) chain A residue 319 type sequence H description BINDING SITE FOR RESIDUE ZN A 1003 source : AC3 27) chain B residue 131 type sequence M description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 28) chain B residue 133 type sequence C description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 29) chain B residue 162 type sequence R description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 30) chain B residue 164 type sequence E description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 31) chain B residue 173 type sequence T description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 32) chain B residue 174 type sequence R description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 33) chain B residue 175 type sequence L description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 34) chain B residue 178 type sequence F description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 35) chain B residue 180 type sequence Q description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 36) chain B residue 182 type sequence D description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 37) chain B residue 287 type sequence Q description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 38) chain B residue 288 type sequence V description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 39) chain B residue 292 type sequence Q description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 40) chain B residue 319 type sequence H description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 41) chain B residue 324 type sequence G description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 42) chain B residue 325 type sequence S description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 43) chain B residue 328 type sequence R description BINDING SITE FOR RESIDUE SSA B 1001 source : AC4 44) chain B residue 403 type sequence V description BINDING SITE FOR RESIDUE SSA B 1002 source : AC5 45) chain B residue 404 type sequence G description BINDING SITE FOR RESIDUE SSA B 1002 source : AC5 46) chain B residue 408 type sequence K description BINDING SITE FOR RESIDUE SSA B 1002 source : AC5 47) chain B residue 411 type sequence I description BINDING SITE FOR RESIDUE SSA B 1002 source : AC5 48) chain B residue 434 type sequence R description BINDING SITE FOR RESIDUE SSA B 1002 source : AC5 49) chain B residue 436 type sequence R description BINDING SITE FOR RESIDUE SSA B 1002 source : AC5 50) chain B residue 439 type sequence R description BINDING SITE FOR RESIDUE SSA B 1002 source : AC5 51) chain B residue 133 type sequence C description BINDING SITE FOR RESIDUE ZN B 1003 source : AC6 52) chain B residue 184 type sequence H description BINDING SITE FOR RESIDUE ZN B 1003 source : AC6 53) chain B residue 319 type sequence H description BINDING SITE FOR RESIDUE ZN B 1003 source : AC6 54) chain C residue 131 type sequence M description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 55) chain C residue 162 type sequence R description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 56) chain C residue 164 type sequence E description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 57) chain C residue 173 type sequence T description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 58) chain C residue 174 type sequence R description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 59) chain C residue 175 type sequence L description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 60) chain C residue 178 type sequence F description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 61) chain C residue 180 type sequence Q description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 62) chain C residue 182 type sequence D description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 63) chain C residue 270 type sequence Y description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 64) chain C residue 273 type sequence K description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 65) chain C residue 287 type sequence Q description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 66) chain C residue 288 type sequence V description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 67) chain C residue 292 type sequence Q description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 68) chain C residue 319 type sequence H description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 69) chain C residue 324 type sequence G description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 70) chain C residue 325 type sequence S description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 71) chain C residue 328 type sequence R description BINDING SITE FOR RESIDUE SSA C 1001 source : AC7 72) chain B residue 408 type sequence K description BINDING SITE FOR RESIDUE SSA C 1002 source : AC8 73) chain C residue 403 type sequence V description BINDING SITE FOR RESIDUE SSA C 1002 source : AC8 74) chain C residue 408 type sequence K description BINDING SITE FOR RESIDUE SSA C 1002 source : AC8 75) chain C residue 411 type sequence I description BINDING SITE FOR RESIDUE SSA C 1002 source : AC8 76) chain C residue 434 type sequence R description BINDING SITE FOR RESIDUE SSA C 1002 source : AC8 77) chain C residue 439 type sequence R description BINDING SITE FOR RESIDUE SSA C 1002 source : AC8 78) chain C residue 133 type sequence C description BINDING SITE FOR RESIDUE ZN C 1003 source : AC9 79) chain C residue 184 type sequence H description BINDING SITE FOR RESIDUE ZN C 1003 source : AC9 80) chain C residue 319 type sequence H description BINDING SITE FOR RESIDUE ZN C 1003 source : AC9 81) chain D residue 131 type sequence M description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 82) chain D residue 133 type sequence C description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 83) chain D residue 162 type sequence R description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 84) chain D residue 164 type sequence E description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 85) chain D residue 173 type sequence T description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 86) chain D residue 175 type sequence L description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 87) chain D residue 178 type sequence F description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 88) chain D residue 180 type sequence Q description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 89) chain D residue 182 type sequence D description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 90) chain D residue 270 type sequence Y description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 91) chain D residue 273 type sequence K description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 92) chain D residue 287 type sequence Q description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 93) chain D residue 288 type sequence V description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 94) chain D residue 292 type sequence Q description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 95) chain D residue 324 type sequence G description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 96) chain D residue 325 type sequence S description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 97) chain D residue 328 type sequence R description BINDING SITE FOR RESIDUE SSA D 1001 source : BC1 98) chain D residue 403 type sequence V description BINDING SITE FOR RESIDUE SSA D 1002 source : BC2 99) chain D residue 408 type sequence K description BINDING SITE FOR RESIDUE SSA D 1002 source : BC2 100) chain D residue 434 type sequence R description BINDING SITE FOR RESIDUE SSA D 1002 source : BC2 101) chain D residue 439 type sequence R description BINDING SITE FOR RESIDUE SSA D 1002 source : BC2 102) chain D residue 133 type sequence C description BINDING SITE FOR RESIDUE ZN D 1003 source : BC3 103) chain D residue 184 type sequence H description BINDING SITE FOR RESIDUE ZN D 1003 source : BC3 104) chain D residue 319 type sequence H description BINDING SITE FOR RESIDUE ZN D 1003 source : BC3

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