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eF-site ID
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4ejx-D |
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PDB Code
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4ejx |
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Chain
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D |
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click to enlarge
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Title
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Structure of ceruloplasmin-myeloperoxidase complex |
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Classification
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OXIDOREDUCTASE |
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Compound
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Ceruloplasmin |
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Source
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ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; |
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Sequence
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D: |
VNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPA
CPGSNITIRNQINALTSFVDASMVYGSEEPLARNLRNMSN
QLGLLAVNQRFQDNGRALLPFDNLHDDPCLLTNRSARIPC
FLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWD
GERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPT
YRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQP
MEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLN
RQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPG
YNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPN
NIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRF
WWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIF
MSNSYPRDFVNCSTLPALNLASWREA
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Description
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Functional site
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|
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1)
|
chain |
D |
| residue |
239 |
| type |
catalytic |
| sequence |
R
|
| description |
601
|
| source |
MCSA : MCSA1
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2)
|
chain |
D |
| residue |
242-252 |
| type |
prosite |
| sequence |
EMPELTSMHTL
|
| description |
PEROXIDASE_1 Peroxidases proximal heme-ligand signature. EMPELTSMHTL
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| source |
prosite : PS00435
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|
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3)
|
chain |
D |
| residue |
168 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000269|PubMed:10766826, ECO:0000269|PubMed:11705390, ECO:0000269|PubMed:7840679, ECO:0007744|PDB:1CXP, ECO:0007744|PDB:1D2V, ECO:0007744|PDB:1D7W, ECO:0007744|PDB:1DNU, ECO:0007744|PDB:1DNW, ECO:0007744|PDB:1MHL
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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4)
|
chain |
D |
| residue |
170 |
| type |
BINDING |
| sequence |
F
|
| description |
BINDING => ECO:0000269|PubMed:10766826, ECO:0000269|PubMed:11705390, ECO:0000269|PubMed:7840679, ECO:0007744|PDB:1CXP, ECO:0007744|PDB:1D2V, ECO:0007744|PDB:1D7W, ECO:0007744|PDB:1DNU, ECO:0007744|PDB:1DNW, ECO:0007744|PDB:1MHL
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| source |
Swiss-Prot : SWS_FT_FI1
|
|
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5)
|
chain |
D |
| residue |
172 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:10766826, ECO:0000269|PubMed:11705390, ECO:0000269|PubMed:7840679, ECO:0007744|PDB:1CXP, ECO:0007744|PDB:1D2V, ECO:0007744|PDB:1D7W, ECO:0007744|PDB:1DNU, ECO:0007744|PDB:1DNW, ECO:0007744|PDB:1MHL
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| source |
Swiss-Prot : SWS_FT_FI1
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|
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6)
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chain |
D |
| residue |
174 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000269|PubMed:10766826, ECO:0000269|PubMed:11705390, ECO:0000269|PubMed:7840679, ECO:0007744|PDB:1CXP, ECO:0007744|PDB:1D2V, ECO:0007744|PDB:1D7W, ECO:0007744|PDB:1DNU, ECO:0007744|PDB:1DNW, ECO:0007744|PDB:1MHL
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
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7)
|
chain |
D |
| residue |
242 |
| type |
BINDING |
| sequence |
E
|
| description |
covalent => ECO:0000269|PubMed:23843990, ECO:0000269|PubMed:7840679, ECO:0007744|PDB:1CXP, ECO:0007744|PDB:4EJX
|
| source |
Swiss-Prot : SWS_FT_FI2
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|
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8)
|
chain |
D |
| residue |
243 |
| type |
BINDING |
| sequence |
M
|
| description |
covalent => ECO:0000269|PubMed:23843990, ECO:0000269|PubMed:7840679, ECO:0007744|PDB:1CXP, ECO:0007744|PDB:4EJX
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
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9)
|
chain |
D |
| residue |
336 |
| type |
BINDING |
| sequence |
H
|
| description |
axial binding residue => ECO:0000269|PubMed:23843990, ECO:0000269|PubMed:7840679, ECO:0007744|PDB:1CXP, ECO:0007744|PDB:4EJX
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
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10)
|
chain |
D |
| residue |
239 |
| type |
SITE |
| sequence |
R
|
| description |
Transition state stabilizer
|
| source |
Swiss-Prot : SWS_FT_FI4
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|
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11)
|
chain |
D |
| residue |
150 |
| type |
MOD_RES |
| sequence |
C
|
| description |
Cysteine sulfenic acid (-SOH) => ECO:0000269|PubMed:7840679
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| source |
Swiss-Prot : SWS_FT_FI5
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|
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12)
|
chain |
D |
| residue |
157 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:20332087
|
| source |
Swiss-Prot : SWS_FT_FI6
|
|
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13)
|
chain |
D |
| residue |
189 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20332087, ECO:0000269|PubMed:23843990, ECO:0007744|PDB:4EJX
|
| source |
Swiss-Prot : SWS_FT_FI7
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|
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14)
|
chain |
D |
| residue |
225 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:20332087, ECO:0000269|PubMed:23843990, ECO:0007744|PDB:4EJX
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| source |
Swiss-Prot : SWS_FT_FI7
|
|
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15)
|
chain |
D |
| residue |
317 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:20332087, ECO:0000269|PubMed:23843990, ECO:0007744|PDB:4EJX
|
| source |
Swiss-Prot : SWS_FT_FI8
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|
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16)
|
chain |
D |
| residue |
563 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:20332087
|
| source |
Swiss-Prot : SWS_FT_FI9
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