eF-site ID 4ej1-A PDB Code 4ej1 Chain A click to enlarge Title Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complex Classification Oxidoreductase/Immune system Compound Dihydrofolate reductase Source Escherichia coli (strain K12) (4EJ1) Sequence A:  MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV IMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDE AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR Description (1)  Dihydrofolate reductase (E.C.1.5.1.3), Nb113 camelid antibody fragment Functional site 1) chain A residue 5 type sequence I description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 2) chain A residue 6 type sequence A description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 3) chain A residue 7 type sequence A description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 4) chain A residue 17 type sequence E description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 5) chain A residue 27 type sequence D description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 6) chain A residue 28 type sequence L description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 7) chain A residue 31 type sequence F description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 8) chain A residue 32 type sequence K description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 9) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 10) chain A residue 52 type sequence R description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 11) chain A residue 57 type sequence R description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 12) chain A residue 94 type sequence I description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 13) chain A residue 100 type sequence Y description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 14) chain A residue 113 type sequence T description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 15) chain A residue 43 type sequence G description BINDING SITE FOR RESIDUE PO4 A 202 source : AC2 16) chain A residue 44 type sequence R description BINDING SITE FOR RESIDUE PO4 A 202 source : AC2 17) chain A residue 45 type sequence H description BINDING SITE FOR RESIDUE PO4 A 202 source : AC2 18) chain A residue 46 type sequence T description BINDING SITE FOR RESIDUE PO4 A 202 source : AC2 19) chain A residue 96 type sequence G description BINDING SITE FOR RESIDUE PO4 A 202 source : AC2 20) chain A residue 44 type sequence R description BINDING SITE FOR RESIDUE PO4 A 203 source : AC3 21) chain A residue 63 type sequence S description BINDING SITE FOR RESIDUE PO4 A 203 source : AC3 22) chain A residue 64 type sequence S description BINDING SITE FOR RESIDUE PO4 A 203 source : AC3 23) chain A residue 144 type sequence D description BINDING SITE FOR RESIDUE PO4 A 204 source : AC4 24) chain A residue 145 type sequence A description BINDING SITE FOR RESIDUE PO4 A 204 source : AC4 25) chain A residue 146 type sequence Q description BINDING SITE FOR RESIDUE PO4 A 204 source : AC4 26) chain A residue 5 type BINDING sequence I description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 27 type BINDING sequence D description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 52 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 29) chain A residue 57 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 113 type BINDING sequence T description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 45 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 32) chain A residue 63 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 33) chain A residue 76 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 95 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 35) chain A residue 13 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 36) chain A residue 7 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 37) chain A residue 13-35 type prosite sequence VIGMENAMPWNLPADLAWFKRNT description DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT source prosite : PS00075

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