eF-site ID 4ej1-B PDB Code 4ej1 Chain B click to enlarge Title Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complex Classification Oxidoreductase/Immune system Compound Dihydrofolate reductase Source Escherichia coli (strain K12) (4EJ1) Sequence B:  MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV IMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDE AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR Description (1)  Dihydrofolate reductase (E.C.1.5.1.3), Nb113 camelid antibody fragment Functional site 1) chain B residue 5 type sequence I description BINDING SITE FOR RESIDUE FOL B 201 source : AC5 2) chain B residue 6 type sequence A description BINDING SITE FOR RESIDUE FOL B 201 source : AC5 3) chain B residue 7 type sequence A description BINDING SITE FOR RESIDUE FOL B 201 source : AC5 4) chain B residue 17 type sequence E description BINDING SITE FOR RESIDUE FOL B 201 source : AC5 5) chain B residue 27 type sequence D description BINDING SITE FOR RESIDUE FOL B 201 source : AC5 6) chain B residue 31 type sequence F description BINDING SITE FOR RESIDUE FOL B 201 source : AC5 7) chain B residue 32 type sequence K description BINDING SITE FOR RESIDUE FOL B 201 source : AC5 8) chain B residue 54 type sequence L description BINDING SITE FOR RESIDUE FOL B 201 source : AC5 9) chain B residue 57 type sequence R description BINDING SITE FOR RESIDUE FOL B 201 source : AC5 10) chain B residue 94 type sequence I description BINDING SITE FOR RESIDUE FOL B 201 source : AC5 11) chain B residue 100 type sequence Y description BINDING SITE FOR RESIDUE FOL B 201 source : AC5 12) chain B residue 113 type sequence T description BINDING SITE FOR RESIDUE FOL B 201 source : AC5 13) chain B residue 43 type sequence G description BINDING SITE FOR RESIDUE PO4 B 202 source : AC6 14) chain B residue 44 type sequence R description BINDING SITE FOR RESIDUE PO4 B 202 source : AC6 15) chain B residue 45 type sequence H description BINDING SITE FOR RESIDUE PO4 B 202 source : AC6 16) chain B residue 46 type sequence T description BINDING SITE FOR RESIDUE PO4 B 202 source : AC6 17) chain B residue 96 type sequence G description BINDING SITE FOR RESIDUE PO4 B 202 source : AC6 18) chain B residue 99 type sequence V description BINDING SITE FOR RESIDUE PO4 B 202 source : AC6 19) chain B residue 44 type sequence R description BINDING SITE FOR RESIDUE PO4 B 203 source : AC7 20) chain B residue 63 type sequence S description BINDING SITE FOR RESIDUE PO4 B 203 source : AC7 21) chain B residue 64 type sequence S description BINDING SITE FOR RESIDUE PO4 B 203 source : AC7 22) chain B residue 98 type sequence R description BINDING SITE FOR RESIDUE PO4 B 203 source : AC7 23) chain B residue 144 type sequence D description BINDING SITE FOR RESIDUE PO4 B 204 source : AC8 24) chain B residue 145 type sequence A description BINDING SITE FOR RESIDUE PO4 B 204 source : AC8 25) chain B residue 146 type sequence Q description BINDING SITE FOR RESIDUE PO4 B 204 source : AC8 26) chain B residue 113 type BINDING sequence T description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 57 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 5 type BINDING sequence I description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 27 type BINDING sequence D description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 52 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 63 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 32) chain B residue 76 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 33) chain B residue 95 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 34) chain B residue 7 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 35) chain B residue 13 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 45 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2

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