eF-site ID 4eiw-ABCDEF PDB Code 4eiw Chain A, B, C, D, E, F click to enlarge Title Whole cytosolic region of atp-dependent metalloprotease FtsH (G399L) Classification HYDROLASE Compound ATP-dependent zinc metalloprotease FtsH Source Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579) (FTSH_THET8) Sequence A:  RARVLTEAPKVTFKDVAGAEEAKEELKEIVEFLKNPSRFH EMGARIPKGVLLVGPPGVGKTHLARAVAGEARVPFITASG SDFVEMFVGVGAARVRDLFETAKRHAPCIVFIDEIDAVGR KRGSGVGGGNDEREQTLNQLLVEMDGFEKDTAIVVMAATN RPDILDPALLRPGRFDRQIAIDAPDVKGREQILRIHARGK PLAEDVDLALLAKRTPGFVGADLENLLNEAALLAAREGRR KITMKDLEEAADRVMMLPAKKSLVLSPRDRRITAYHEAGH ALAAHFLEHADGVHKVTIVPRGRALGFMMPRREDMLHWSR KRLLDQIAVALAGRAAEEIVFDDVTTGAENDFRQATELAR RMITEWGMHPEFGPVAYAVREDTYLGGYDVRQYSEETAKR IDEAVRRLIEEQYQRVKALLLEKREVLERVAETLLERETL TAEEFQRVVEGLPLEAPE B:  LTEAPKVTFKDVAGAEEAKEELKEIVEFLKNPSRFHEMGA RIPKGVLLVGPPGVGKTHLARAVAGEARVPFITASGSDFV EMFVGVGAARVRDLFETAKRHAPCIVFIDEIDAVGRKNDE REQTLNQLLVEMDGFEKDTAIVVMAATNRPDILDPALLRP GRFDRQIAIDAPDVKGREQILRIHARGKPLAEDVDLALLA KRTPGFVGADLENLLNEAALLAAREGRRKITMKDLEEAAD RVMMLPAKKSLVLSPRDRRITAYHEAGHALAAHFLEHADG VHKVTIVPRGRALGFMMPRREDMLHWSRKRLLDQIAVALA GRAAEEIVFDDVTTGAENDFRQATELARRMITEWGMHPEF GPVAYAVREDTYLGGYDVRQYSEETAKRIDEAVRRLIEEQ YQRVKALLLEKREVLERVAETLLERETLTAEEFQRVVEGL PLEAPE C:  RARVLTEAPKVTFKDVAGAEEAKEELKEIVEFLKNPSRFH EMGARIPKGVLLVGPPGVGKTHLARAVAGEARVPFITASG SDFVEMFVGVGAARVRDLFETAKRHAPCIVFIDEIDAVGR KRGSGVGGGNDEREQTLNQLLVEMDGFEKDTAIVVMAATN RPDILDPALLRPGRFDRQIAIDAPDVKGREQILRIHARGK PLAEDVDLALLAKRTPGFVGADLENLLNEAALLAAREGRR KITMKDLEEAADRVMMLPAKKSLVLSPRDRRITAYHEAGH ALAAHFLEHADGVHKVTIVPRGRALGFMMPRREDMLHWSR KRLLDQIAVALAGRAAEEIVFDDVTTGAENDFRQATELAR RMITEWGMHPEFGPVAYAVREDTYLGGYDVRQYSEETAKR IDEAVRRLIEEQYQRVKALLLEKREVLERVAETLLERETL TAEEFQRVVEGLPLEAPE D:  LTEAPKVTFKDVAGAEEAKEELKEIVEFLKNPSRFHEMGA RIPKGVLLVGPPGVGKTHLARAVAGEARVPFITASGSDFV EMFVGVGAARVRDLFETAKRHAPCIVFIDEIDAVGRKNDE REQTLNQLLVEMDGFEKDTAIVVMAATNRPDILDPALLRP GRFDRQIAIDAPDVKGREQILRIHARGKPLAEDVDLALLA KRTPGFVGADLENLLNEAALLAAREGRRKITMKDLEEAAD RVMMLPAKKSLVLSPRDRRITAYHEAGHALAAHFLEHADG VHKVTIVPRGRALGFMMPRREDMLHWSRKRLLDQIAVALA GRAAEEIVFDDVTTGAENDFRQATELARRMITEWGMHPEF GPVAYAVREDTYLGGYDVRQYSEETAKRIDEAVRRLIEEQ YQRVKALLLEKREVLERVAETLLERETLTAEEFQRVVEGL PLEAPE E:  RARVLTEAPKVTFKDVAGAEEAKEELKEIVEFLKNPSRFH EMGARIPKGVLLVGPPGVGKTHLARAVAGEARVPFITASG SDFVEMFVGVGAARVRDLFETAKRHAPCIVFIDEIDAVGR KRGSGVGGGNDEREQTLNQLLVEMDGFEKDTAIVVMAATN RPDILDPALLRPGRFDRQIAIDAPDVKGREQILRIHARGK PLAEDVDLALLAKRTPGFVGADLENLLNEAALLAAREGRR KITMKDLEEAADRVMMLPAKKSLVLSPRDRRITAYHEAGH ALAAHFLEHADGVHKVTIVPRGRALGFMMPRREDMLHWSR KRLLDQIAVALAGRAAEEIVFDDVTTGAENDFRQATELAR RMITEWGMHPEFGPVAYAVREDTYLGGYDVRQYSEETAKR IDEAVRRLIEEQYQRVKALLLEKREVLERVAETLLERETL TAEEFQRVVEGLPLEAPE F:  LTEAPKVTFKDVAGAEEAKEELKEIVEFLKNPSRFHEMGA RIPKGVLLVGPPGVGKTHLARAVAGEARVPFITASGSDFV EMFVGVGAARVRDLFETAKRHAPCIVFIDEIDAVGRKNDE REQTLNQLLVEMDGFEKDTAIVVMAATNRPDILDPALLRP GRFDRQIAIDAPDVKGREQILRIHARGKPLAEDVDLALLA KRTPGFVGADLENLLNEAALLAAREGRRKITMKDLEEAAD RVMMLPAKKSLVLSPRDRRITAYHEAGHALAAHFLEHADG VHKVTIVPRGRALGFMMPRREDMLHWSRKRLLDQIAVALA GRAAEEIVFDDVTTGAENDFRQATELARRMITEWGMHPEF GPVAYAVREDTYLGGYDVRQYSEETAKRIDEAVRRLIEEQ YQRVKALLLEKREVLERVAETLLERETLTAEEFQRVVEGL PLEAPE Description Functional site 1) chain A residue 197 type sequence P description BINDING SITE FOR RESIDUE ADP A 1001 source : AC1 2) chain A residue 198 type sequence P description BINDING SITE FOR RESIDUE ADP A 1001 source : AC1 3) chain A residue 199 type sequence G description BINDING SITE FOR RESIDUE ADP A 1001 source : AC1 4) chain A residue 200 type sequence V description BINDING SITE FOR RESIDUE ADP A 1001 source : AC1 5) chain A residue 201 type sequence G description BINDING SITE FOR RESIDUE ADP A 1001 source : AC1 6) chain A residue 202 type sequence K description BINDING SITE FOR RESIDUE ADP A 1001 source : AC1 7) chain A residue 203 type sequence T description BINDING SITE FOR RESIDUE ADP A 1001 source : AC1 8) chain A residue 204 type sequence H description BINDING SITE FOR RESIDUE ADP A 1001 source : AC1 9) chain A residue 334 type sequence I description BINDING SITE FOR RESIDUE ADP A 1001 source : AC1 10) chain A residue 338 type sequence H description BINDING SITE FOR RESIDUE ADP A 1001 source : AC1 11) chain A residue 362 type sequence G description BINDING SITE FOR RESIDUE ADP A 1001 source : AC1 12) chain A residue 363 type sequence A description BINDING SITE FOR RESIDUE ADP A 1001 source : AC1 13) chain B residue 158 type sequence V description BINDING SITE FOR RESIDUE ADP B 2001 source : AC2 14) chain B residue 159 type sequence A description BINDING SITE FOR RESIDUE ADP B 2001 source : AC2 15) chain B residue 198 type sequence P description BINDING SITE FOR RESIDUE ADP B 2001 source : AC2 16) chain B residue 199 type sequence G description BINDING SITE FOR RESIDUE ADP B 2001 source : AC2 17) chain B residue 200 type sequence V description BINDING SITE FOR RESIDUE ADP B 2001 source : AC2 18) chain B residue 201 type sequence G description BINDING SITE FOR RESIDUE ADP B 2001 source : AC2 19) chain B residue 202 type sequence K description BINDING SITE FOR RESIDUE ADP B 2001 source : AC2 20) chain B residue 203 type sequence T description BINDING SITE FOR RESIDUE ADP B 2001 source : AC2 21) chain B residue 204 type sequence H description BINDING SITE FOR RESIDUE ADP B 2001 source : AC2 22) chain B residue 334 type sequence I description BINDING SITE FOR RESIDUE ADP B 2001 source : AC2 23) chain B residue 338 type sequence H description BINDING SITE FOR RESIDUE ADP B 2001 source : AC2 24) chain B residue 362 type sequence G description BINDING SITE FOR RESIDUE ADP B 2001 source : AC2 25) chain B residue 363 type sequence A description BINDING SITE FOR RESIDUE ADP B 2001 source : AC2 26) chain B residue 366 type sequence E description BINDING SITE FOR RESIDUE ADP B 2001 source : AC2 27) chain C residue 197 type sequence P description BINDING SITE FOR RESIDUE ADP C 1001 source : AC3 28) chain C residue 198 type sequence P description BINDING SITE FOR RESIDUE ADP C 1001 source : AC3 29) chain C residue 199 type sequence G description BINDING SITE FOR RESIDUE ADP C 1001 source : AC3 30) chain C residue 200 type sequence V description BINDING SITE FOR RESIDUE ADP C 1001 source : AC3 31) chain C residue 201 type sequence G description BINDING SITE FOR RESIDUE ADP C 1001 source : AC3 32) chain C residue 202 type sequence K description BINDING SITE FOR RESIDUE ADP C 1001 source : AC3 33) chain C residue 203 type sequence T description BINDING SITE FOR RESIDUE ADP C 1001 source : AC3 34) chain C residue 204 type sequence H description BINDING SITE FOR RESIDUE ADP C 1001 source : AC3 35) chain C residue 334 type sequence I description BINDING SITE FOR RESIDUE ADP C 1001 source : AC3 36) chain C residue 338 type sequence H description BINDING SITE FOR RESIDUE ADP C 1001 source : AC3 37) chain C residue 362 type sequence G description BINDING SITE FOR RESIDUE ADP C 1001 source : AC3 38) chain C residue 363 type sequence A description BINDING SITE FOR RESIDUE ADP C 1001 source : AC3 39) chain D residue 158 type sequence V description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 40) chain D residue 159 type sequence A description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 41) chain D residue 197 type sequence P description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 42) chain D residue 198 type sequence P description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 43) chain D residue 199 type sequence G description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 44) chain D residue 200 type sequence V description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 45) chain D residue 201 type sequence G description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 46) chain D residue 202 type sequence K description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 47) chain D residue 203 type sequence T description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 48) chain D residue 204 type sequence H description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 49) chain D residue 334 type sequence I description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 50) chain D residue 338 type sequence H description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 51) chain D residue 362 type sequence G description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 52) chain D residue 363 type sequence A description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 53) chain D residue 366 type sequence E description BINDING SITE FOR RESIDUE ADP D 2001 source : AC4 54) chain E residue 197 type sequence P description BINDING SITE FOR RESIDUE ADP E 1001 source : AC5 55) chain E residue 198 type sequence P description BINDING SITE FOR RESIDUE ADP E 1001 source : AC5 56) chain E residue 199 type sequence G description BINDING SITE FOR RESIDUE ADP E 1001 source : AC5 57) chain E residue 200 type sequence V description BINDING SITE FOR RESIDUE ADP E 1001 source : AC5 58) chain E residue 201 type sequence G description BINDING SITE FOR RESIDUE ADP E 1001 source : AC5 59) chain E residue 202 type sequence K description BINDING SITE FOR RESIDUE ADP E 1001 source : AC5 60) chain E residue 203 type sequence T description BINDING SITE FOR RESIDUE ADP E 1001 source : AC5 61) chain E residue 204 type sequence H description BINDING SITE FOR RESIDUE ADP E 1001 source : AC5 62) chain E residue 334 type sequence I description BINDING SITE FOR RESIDUE ADP E 1001 source : AC5 63) chain E residue 338 type sequence H description BINDING SITE FOR RESIDUE ADP E 1001 source : AC5 64) chain E residue 362 type sequence G description BINDING SITE FOR RESIDUE ADP E 1001 source : AC5 65) chain E residue 363 type sequence A description BINDING SITE FOR RESIDUE ADP E 1001 source : AC5 66) chain F residue 158 type sequence V description BINDING SITE FOR RESIDUE ADP F 2001 source : AC6 67) chain F residue 159 type sequence A description BINDING SITE FOR RESIDUE ADP F 2001 source : AC6 68) chain F residue 198 type sequence P description BINDING SITE FOR RESIDUE ADP F 2001 source : AC6 69) chain F residue 199 type sequence G description BINDING SITE FOR RESIDUE ADP F 2001 source : AC6 70) chain F residue 200 type sequence V description BINDING SITE FOR RESIDUE ADP F 2001 source : AC6 71) chain F residue 201 type sequence G description BINDING SITE FOR RESIDUE ADP F 2001 source : AC6 72) chain F residue 202 type sequence K description BINDING SITE FOR RESIDUE ADP F 2001 source : AC6 73) chain F residue 203 type sequence T description BINDING SITE FOR RESIDUE ADP F 2001 source : AC6 74) chain F residue 204 type sequence H description BINDING SITE FOR RESIDUE ADP F 2001 source : AC6 75) chain F residue 334 type sequence I description BINDING SITE FOR RESIDUE ADP F 2001 source : AC6 76) chain F residue 338 type sequence H description BINDING SITE FOR RESIDUE ADP F 2001 source : AC6 77) chain F residue 363 type sequence A description BINDING SITE FOR RESIDUE ADP F 2001 source : AC6 78) chain F residue 366 type sequence E description BINDING SITE FOR RESIDUE ADP F 2001 source : AC6 79) chain A residue 419 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI1 80) chain B residue 419 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI1 81) chain C residue 419 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI1 82) chain D residue 419 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI1 83) chain E residue 419 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI1 84) chain F residue 419 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI1 85) chain A residue 159 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 86) chain D residue 159 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 87) chain D residue 199 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 88) chain D residue 204 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 89) chain E residue 159 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 90) chain E residue 199 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 91) chain E residue 204 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 92) chain F residue 159 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 93) chain F residue 199 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 94) chain F residue 204 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 95) chain A residue 199 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 96) chain A residue 204 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 97) chain B residue 159 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 98) chain B residue 199 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 99) chain B residue 204 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 100) chain C residue 159 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 101) chain C residue 199 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI2 102) chain C residue 204 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI2 103) chain A residue 418 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 104) chain D residue 418 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 105) chain D residue 422 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 106) chain D residue 493 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 107) chain E residue 418 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 108) chain E residue 422 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 109) chain E residue 493 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 110) chain F residue 418 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 111) chain F residue 422 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 112) chain F residue 493 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 113) chain A residue 422 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 114) chain A residue 493 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 115) chain B residue 418 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 116) chain B residue 422 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 117) chain B residue 493 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 118) chain C residue 418 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 119) chain C residue 422 type BINDING sequence H description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 120) chain C residue 493 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01458 source Swiss-Prot : SWS_FT_FI3 121) chain A residue 295-313 type prosite sequence IVVMAATNRPDILDPALLR description AAA AAA-protein family signature. IvVMaATNrpdiLDpALl.R source prosite : PS00674

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