eF-site ID 4edz-D PDB Code 4edz Chain D click to enlarge Title Crystal structure of hH-PGDS with water displacing inhibitor Classification Isomerase/Isomerase inhibitor Compound Hematopoietic prostaglandin D synthase Source Homo sapiens (Human) (HPGDS_HUMAN) Sequence D:  APNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWP EIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGN TEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELL TYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTL LVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL Description Functional site 1) chain D residue 97 type sequence D description BINDING SITE FOR RESIDUE GSH C 202 source : AC7 2) chain D residue 8 type sequence Y description BINDING SITE FOR RESIDUE GSH D 201 source : AC9 3) chain D residue 14 type sequence R description BINDING SITE FOR RESIDUE GSH D 201 source : AC9 4) chain D residue 39 type sequence W description BINDING SITE FOR RESIDUE GSH D 201 source : AC9 5) chain D residue 43 type sequence K description BINDING SITE FOR RESIDUE GSH D 201 source : AC9 6) chain D residue 50 type sequence K description BINDING SITE FOR RESIDUE GSH D 201 source : AC9 7) chain D residue 51 type sequence I description BINDING SITE FOR RESIDUE GSH D 201 source : AC9 8) chain D residue 63 type sequence Q description BINDING SITE FOR RESIDUE GSH D 201 source : AC9 9) chain D residue 64 type sequence S description BINDING SITE FOR RESIDUE GSH D 201 source : AC9 10) chain D residue 8 type sequence Y description BINDING SITE FOR RESIDUE 0O5 D 202 source : BC1 11) chain D residue 9 type sequence F description BINDING SITE FOR RESIDUE 0O5 D 202 source : BC1 12) chain D residue 11 type sequence M description BINDING SITE FOR RESIDUE 0O5 D 202 source : BC1 13) chain D residue 13 type sequence G description BINDING SITE FOR RESIDUE 0O5 D 202 source : BC1 14) chain D residue 14 type sequence R description BINDING SITE FOR RESIDUE 0O5 D 202 source : BC1 15) chain D residue 36 type sequence Q description BINDING SITE FOR RESIDUE 0O5 D 202 source : BC1 16) chain D residue 96 type sequence D description BINDING SITE FOR RESIDUE 0O5 D 202 source : BC1 17) chain D residue 99 type sequence M description BINDING SITE FOR RESIDUE 0O5 D 202 source : BC1 18) chain D residue 104 type sequence W description BINDING SITE FOR RESIDUE 0O5 D 202 source : BC1 19) chain D residue 152 type sequence Y description BINDING SITE FOR RESIDUE 0O5 D 202 source : BC1 20) chain D residue 155 type sequence I description BINDING SITE FOR RESIDUE 0O5 D 202 source : BC1 21) chain D residue 8 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 14 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 23) chain D residue 39 type BINDING sequence W description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 24) chain D residue 49 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 63 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1

Display surface Download Links