eF-site ID 4edz-C PDB Code 4edz Chain C click to enlarge Title Crystal structure of hH-PGDS with water displacing inhibitor Classification Isomerase/Isomerase inhibitor Compound Hematopoietic prostaglandin D synthase Source Homo sapiens (Human) (HPGDS_HUMAN) Sequence C:  PNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPE IKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNT EMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLT YNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLL VFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL Description Functional site 1) chain C residue 8 type sequence Y description BINDING SITE FOR RESIDUE GSH C 202 source : AC7 2) chain C residue 14 type sequence R description BINDING SITE FOR RESIDUE GSH C 202 source : AC7 3) chain C residue 39 type sequence W description BINDING SITE FOR RESIDUE GSH C 202 source : AC7 4) chain C residue 43 type sequence K description BINDING SITE FOR RESIDUE GSH C 202 source : AC7 5) chain C residue 50 type sequence K description BINDING SITE FOR RESIDUE GSH C 202 source : AC7 6) chain C residue 51 type sequence I description BINDING SITE FOR RESIDUE GSH C 202 source : AC7 7) chain C residue 63 type sequence Q description BINDING SITE FOR RESIDUE GSH C 202 source : AC7 8) chain C residue 64 type sequence S description BINDING SITE FOR RESIDUE GSH C 202 source : AC7 9) chain C residue 13 type sequence G description BINDING SITE FOR RESIDUE 0O5 C 203 source : AC8 10) chain C residue 14 type sequence R description BINDING SITE FOR RESIDUE 0O5 C 203 source : AC8 11) chain C residue 36 type sequence Q description BINDING SITE FOR RESIDUE 0O5 C 203 source : AC8 12) chain C residue 96 type sequence D description BINDING SITE FOR RESIDUE 0O5 C 203 source : AC8 13) chain C residue 99 type sequence M description BINDING SITE FOR RESIDUE 0O5 C 203 source : AC8 14) chain C residue 100 type sequence S description BINDING SITE FOR RESIDUE 0O5 C 203 source : AC8 15) chain C residue 104 type sequence W description BINDING SITE FOR RESIDUE 0O5 C 203 source : AC8 16) chain C residue 152 type sequence Y description BINDING SITE FOR RESIDUE 0O5 C 203 source : AC8 17) chain C residue 155 type sequence I description BINDING SITE FOR RESIDUE 0O5 C 203 source : AC8 18) chain C residue 199 type sequence L description BINDING SITE FOR RESIDUE 0O5 C 203 source : AC8 19) chain C residue 97 type sequence D description BINDING SITE FOR RESIDUE GSH D 201 source : AC9 20) chain C residue 8 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 21) chain C residue 14 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 22) chain C residue 39 type BINDING sequence W description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 23) chain C residue 49 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 24) chain C residue 63 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1

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