eF-site ID 4edz-B PDB Code 4edz Chain B click to enlarge Title Crystal structure of hH-PGDS with water displacing inhibitor Classification Isomerase/Isomerase inhibitor Compound Hematopoietic prostaglandin D synthase Source Homo sapiens (Human) (HPGDS_HUMAN) Sequence B:  APNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWP EIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGN TEMEQCHVDAIVDTLDDFMSCFPWAEQDVKEQMFNELLTY NAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLV FKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL Description Functional site 1) chain B residue 97 type sequence D description BINDING SITE FOR RESIDUE GSH A 201 source : AC1 2) chain B residue 8 type sequence Y description BINDING SITE FOR RESIDUE GSH B 202 source : AC4 3) chain B residue 14 type sequence R description BINDING SITE FOR RESIDUE GSH B 202 source : AC4 4) chain B residue 39 type sequence W description BINDING SITE FOR RESIDUE GSH B 202 source : AC4 5) chain B residue 43 type sequence K description BINDING SITE FOR RESIDUE GSH B 202 source : AC4 6) chain B residue 50 type sequence K description BINDING SITE FOR RESIDUE GSH B 202 source : AC4 7) chain B residue 51 type sequence I description BINDING SITE FOR RESIDUE GSH B 202 source : AC4 8) chain B residue 52 type sequence P description BINDING SITE FOR RESIDUE GSH B 202 source : AC4 9) chain B residue 63 type sequence Q description BINDING SITE FOR RESIDUE GSH B 202 source : AC4 10) chain B residue 64 type sequence S description BINDING SITE FOR RESIDUE GSH B 202 source : AC4 11) chain B residue 9 type sequence F description BINDING SITE FOR RESIDUE 0O5 B 203 source : AC5 12) chain B residue 11 type sequence M description BINDING SITE FOR RESIDUE 0O5 B 203 source : AC5 13) chain B residue 13 type sequence G description BINDING SITE FOR RESIDUE 0O5 B 203 source : AC5 14) chain B residue 14 type sequence R description BINDING SITE FOR RESIDUE 0O5 B 203 source : AC5 15) chain B residue 36 type sequence Q description BINDING SITE FOR RESIDUE 0O5 B 203 source : AC5 16) chain B residue 96 type sequence D description BINDING SITE FOR RESIDUE 0O5 B 203 source : AC5 17) chain B residue 99 type sequence M description BINDING SITE FOR RESIDUE 0O5 B 203 source : AC5 18) chain B residue 100 type sequence S description BINDING SITE FOR RESIDUE 0O5 B 203 source : AC5 19) chain B residue 104 type sequence W description BINDING SITE FOR RESIDUE 0O5 B 203 source : AC5 20) chain B residue 152 type sequence Y description BINDING SITE FOR RESIDUE 0O5 B 203 source : AC5 21) chain B residue 155 type sequence I description BINDING SITE FOR RESIDUE 0O5 B 203 source : AC5 22) chain B residue 199 type sequence L description BINDING SITE FOR RESIDUE 0O5 B 203 source : AC5 23) chain B residue 8 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 14 type BINDING sequence R description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 39 type BINDING sequence W description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 49 type BINDING sequence G description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 63 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:12627223, ECO:0000269|PubMed:15113825, ECO:0000269|PubMed:16547010, ECO:0000269|PubMed:18341273, ECO:0000269|PubMed:19939518 source Swiss-Prot : SWS_FT_FI1

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