eF-site ID 4e4v-B PDB Code 4e4v Chain B click to enlarge Title The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution. Classification TRANSPORT PROTEIN Compound Importin subunit alpha-2 Source Homo sapiens (Human) (IMA2_HUMAN) Sequence B:  MLDALNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLL SREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWAL TNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVW ALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACG YLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDD PEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGA SELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLL TNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVS VLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEP LMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMI EECGGLDKIEALQNHENESVYRASLSLIEKYFS Description Functional site 1) chain B residue 399 type sequence W description BINDING SITE FOR RESIDUE GOL A 601 source : AC1 2) chain B residue 442 type sequence D description BINDING SITE FOR RESIDUE GOL A 601 source : AC1 3) chain B residue 376 type sequence H description BINDING SITE FOR RESIDUE GOL A 602 source : AC2 4) chain B residue 480 type sequence E description BINDING SITE FOR RESIDUE GOL A 603 source : AC3 5) chain B residue 223 type sequence C description BINDING SITE FOR RESIDUE GOL B 601 source : BC1 6) chain B residue 224 type sequence G description BINDING SITE FOR RESIDUE GOL B 601 source : BC1 7) chain B residue 371 type sequence Q description BINDING SITE FOR RESIDUE GOL B 602 source : BC2 8) chain B residue 411 type sequence E description BINDING SITE FOR RESIDUE GOL B 602 source : BC2 9) chain B residue 412 type sequence Q description BINDING SITE FOR RESIDUE GOL B 602 source : BC2 10) chain B residue 353 type sequence K description BINDING SITE FOR RESIDUE GOL B 603 source : BC3 11) chain B residue 354 type sequence E description BINDING SITE FOR RESIDUE GOL B 603 source : BC3 12) chain B residue 396 type sequence E description BINDING SITE FOR RESIDUE GOL B 603 source : BC3 13) chain B residue 431 type sequence A description BINDING SITE FOR RESIDUE GOL B 604 source : BC4 14) chain B residue 432 type sequence K description BINDING SITE FOR RESIDUE GOL B 604 source : BC4 15) chain B residue 433 type sequence D description BINDING SITE FOR RESIDUE GOL B 604 source : BC4 16) chain B residue 228 type sequence N description BINDING SITE FOR RESIDUE GOL B 605 source : BC5 17) chain B residue 418 type sequence H description BINDING SITE FOR RESIDUE DTT B 606 source : BC6 18) chain B residue 456 type sequence E description BINDING SITE FOR RESIDUE DTT B 606 source : BC6 19) chain B residue 490 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1

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