eF-site ID 4e4v-AB PDB Code 4e4v Chain A, B click to enlarge Title The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution. Classification TRANSPORT PROTEIN Compound Importin subunit alpha-2 Source Homo sapiens (Human) (IMA2_HUMAN) Sequence A:  MLDALNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLL SREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWAL TNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVW ALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACG YLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDD PEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGA SELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLL TNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVS VLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEP LMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMI EECGGLDKIEALQNHENESVYRASLSLIEKYFS B:  MLDALNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLL SREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWAL TNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVW ALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACG YLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDD PEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGA SELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLL TNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVS VLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEP LMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMI EECGGLDKIEALQNHENESVYRASLSLIEKYFS Description Functional site 1) chain A residue 101 type sequence R description BINDING SITE FOR RESIDUE GOL A 601 source : AC1 2) chain A residue 102 type sequence K description BINDING SITE FOR RESIDUE GOL A 601 source : AC1 3) chain A residue 105 type sequence S description BINDING SITE FOR RESIDUE GOL A 601 source : AC1 4) chain B residue 399 type sequence W description BINDING SITE FOR RESIDUE GOL A 601 source : AC1 5) chain B residue 442 type sequence D description BINDING SITE FOR RESIDUE GOL A 601 source : AC1 6) chain A residue 116 type sequence I description BINDING SITE FOR RESIDUE GOL A 602 source : AC2 7) chain B residue 376 type sequence H description BINDING SITE FOR RESIDUE GOL A 602 source : AC2 8) chain A residue 174 type sequence P description BINDING SITE FOR RESIDUE GOL A 603 source : AC3 9) chain A residue 175 type sequence H description BINDING SITE FOR RESIDUE GOL A 603 source : AC3 10) chain A residue 176 type sequence A description BINDING SITE FOR RESIDUE GOL A 603 source : AC3 11) chain A residue 177 type sequence H description BINDING SITE FOR RESIDUE GOL A 603 source : AC3 12) chain B residue 480 type sequence E description BINDING SITE FOR RESIDUE GOL A 603 source : AC3 13) chain A residue 217 type sequence D description BINDING SITE FOR RESIDUE GOL A 604 source : AC4 14) chain A residue 218 type sequence M description BINDING SITE FOR RESIDUE GOL A 604 source : AC4 15) chain A residue 258 type sequence R description BINDING SITE FOR RESIDUE GOL A 604 source : AC4 16) chain A residue 262 type sequence H description BINDING SITE FOR RESIDUE GOL A 604 source : AC4 17) chain A residue 372 type sequence Q description BINDING SITE FOR RESIDUE GOL A 605 source : AC5 18) chain A residue 376 type sequence H description BINDING SITE FOR RESIDUE GOL A 605 source : AC5 19) chain A residue 374 type sequence V description BINDING SITE FOR RESIDUE GOL A 606 source : AC6 20) chain A residue 377 type sequence G description BINDING SITE FOR RESIDUE GOL A 606 source : AC6 21) chain A residue 131 type sequence T description BINDING SITE FOR RESIDUE GOL A 607 source : AC7 22) chain A residue 137 type sequence Q description BINDING SITE FOR RESIDUE GOL A 607 source : AC7 23) chain A residue 169 type sequence S description BINDING SITE FOR RESIDUE GOL A 607 source : AC7 24) chain A residue 371 type sequence Q description BINDING SITE FOR RESIDUE GOL A 608 source : AC8 25) chain A residue 374 type sequence V description BINDING SITE FOR RESIDUE GOL A 608 source : AC8 26) chain A residue 411 type sequence E description BINDING SITE FOR RESIDUE GOL A 608 source : AC8 27) chain A residue 412 type sequence Q description BINDING SITE FOR RESIDUE GOL A 608 source : AC8 28) chain A residue 415 type sequence Y description BINDING SITE FOR RESIDUE GOL A 608 source : AC8 29) chain A residue 454 type sequence L description BINDING SITE FOR RESIDUE DTT A 609 source : AC9 30) chain A residue 456 type sequence E description BINDING SITE FOR RESIDUE DTT A 609 source : AC9 31) chain A residue 459 type sequence K description BINDING SITE FOR RESIDUE DTT A 609 source : AC9 32) chain A residue 431 type sequence A description BINDING SITE FOR RESIDUE GOL B 601 source : BC1 33) chain A residue 432 type sequence K description BINDING SITE FOR RESIDUE GOL B 601 source : BC1 34) chain B residue 223 type sequence C description BINDING SITE FOR RESIDUE GOL B 601 source : BC1 35) chain B residue 224 type sequence G description BINDING SITE FOR RESIDUE GOL B 601 source : BC1 36) chain B residue 371 type sequence Q description BINDING SITE FOR RESIDUE GOL B 602 source : BC2 37) chain B residue 411 type sequence E description BINDING SITE FOR RESIDUE GOL B 602 source : BC2 38) chain B residue 412 type sequence Q description BINDING SITE FOR RESIDUE GOL B 602 source : BC2 39) chain B residue 353 type sequence K description BINDING SITE FOR RESIDUE GOL B 603 source : BC3 40) chain B residue 354 type sequence E description BINDING SITE FOR RESIDUE GOL B 603 source : BC3 41) chain B residue 396 type sequence E description BINDING SITE FOR RESIDUE GOL B 603 source : BC3 42) chain B residue 431 type sequence A description BINDING SITE FOR RESIDUE GOL B 604 source : BC4 43) chain B residue 432 type sequence K description BINDING SITE FOR RESIDUE GOL B 604 source : BC4 44) chain B residue 433 type sequence D description BINDING SITE FOR RESIDUE GOL B 604 source : BC4 45) chain B residue 228 type sequence N description BINDING SITE FOR RESIDUE GOL B 605 source : BC5 46) chain B residue 418 type sequence H description BINDING SITE FOR RESIDUE DTT B 606 source : BC6 47) chain B residue 456 type sequence E description BINDING SITE FOR RESIDUE DTT B 606 source : BC6 48) chain A residue 490 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1 49) chain B residue 490 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1

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