eF-site ID 4e4v-A PDB Code 4e4v Chain A click to enlarge Title The crystal structure of the dimeric human importin alpha 1 at 2.5 angstrom resolution. Classification TRANSPORT PROTEIN Compound Importin subunit alpha-2 Source Homo sapiens (Human) (IMA2_HUMAN) Sequence A:  MLDALNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLL SREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWAL TNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVW ALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACG YLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDD PEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGA SELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLL TNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVS VLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEP LMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMI EECGGLDKIEALQNHENESVYRASLSLIEKYFS Description Functional site 1) chain A residue 101 type sequence R description BINDING SITE FOR RESIDUE GOL A 601 source : AC1 2) chain A residue 102 type sequence K description BINDING SITE FOR RESIDUE GOL A 601 source : AC1 3) chain A residue 105 type sequence S description BINDING SITE FOR RESIDUE GOL A 601 source : AC1 4) chain A residue 116 type sequence I description BINDING SITE FOR RESIDUE GOL A 602 source : AC2 5) chain A residue 174 type sequence P description BINDING SITE FOR RESIDUE GOL A 603 source : AC3 6) chain A residue 175 type sequence H description BINDING SITE FOR RESIDUE GOL A 603 source : AC3 7) chain A residue 176 type sequence A description BINDING SITE FOR RESIDUE GOL A 603 source : AC3 8) chain A residue 177 type sequence H description BINDING SITE FOR RESIDUE GOL A 603 source : AC3 9) chain A residue 217 type sequence D description BINDING SITE FOR RESIDUE GOL A 604 source : AC4 10) chain A residue 218 type sequence M description BINDING SITE FOR RESIDUE GOL A 604 source : AC4 11) chain A residue 258 type sequence R description BINDING SITE FOR RESIDUE GOL A 604 source : AC4 12) chain A residue 262 type sequence H description BINDING SITE FOR RESIDUE GOL A 604 source : AC4 13) chain A residue 372 type sequence Q description BINDING SITE FOR RESIDUE GOL A 605 source : AC5 14) chain A residue 376 type sequence H description BINDING SITE FOR RESIDUE GOL A 605 source : AC5 15) chain A residue 374 type sequence V description BINDING SITE FOR RESIDUE GOL A 606 source : AC6 16) chain A residue 377 type sequence G description BINDING SITE FOR RESIDUE GOL A 606 source : AC6 17) chain A residue 131 type sequence T description BINDING SITE FOR RESIDUE GOL A 607 source : AC7 18) chain A residue 137 type sequence Q description BINDING SITE FOR RESIDUE GOL A 607 source : AC7 19) chain A residue 169 type sequence S description BINDING SITE FOR RESIDUE GOL A 607 source : AC7 20) chain A residue 371 type sequence Q description BINDING SITE FOR RESIDUE GOL A 608 source : AC8 21) chain A residue 374 type sequence V description BINDING SITE FOR RESIDUE GOL A 608 source : AC8 22) chain A residue 411 type sequence E description BINDING SITE FOR RESIDUE GOL A 608 source : AC8 23) chain A residue 412 type sequence Q description BINDING SITE FOR RESIDUE GOL A 608 source : AC8 24) chain A residue 415 type sequence Y description BINDING SITE FOR RESIDUE GOL A 608 source : AC8 25) chain A residue 454 type sequence L description BINDING SITE FOR RESIDUE DTT A 609 source : AC9 26) chain A residue 456 type sequence E description BINDING SITE FOR RESIDUE DTT A 609 source : AC9 27) chain A residue 459 type sequence K description BINDING SITE FOR RESIDUE DTT A 609 source : AC9 28) chain A residue 431 type sequence A description BINDING SITE FOR RESIDUE GOL B 601 source : BC1 29) chain A residue 432 type sequence K description BINDING SITE FOR RESIDUE GOL B 601 source : BC1 30) chain A residue 490 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI1

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