eF-site ID 4e4k-AB PDB Code 4e4k Chain A, B click to enlarge Title Crystal Structure of PPARgamma with the ligand JO21 Classification TRANSCRIPTION Compound Peroxisome proliferator-activated receptor gamma Source Homo sapiens (Human) (PPARG_HUMAN) Sequence A:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSP FVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQ FRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEII YTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEP KFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPI EDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIV TEHVQLLQVIKKTETDMSLHPLLQEIYK B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSP FVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQ FRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEII YTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEP KFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPI EDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIV TEHVQLLQVIKKTETDMSLHPLLQEIYK Description Functional site 1) chain A residue 264 type sequence F description BINDING SITE FOR RESIDUE RRG A 501 source : AC1 2) chain A residue 266 type sequence H description BINDING SITE FOR RESIDUE RRG A 501 source : AC1 3) chain A residue 282 type sequence F description BINDING SITE FOR RESIDUE RRG A 501 source : AC1 4) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE RRG A 501 source : AC1 5) chain A residue 288 type sequence R description BINDING SITE FOR RESIDUE RRG A 501 source : AC1 6) chain A residue 327 type sequence Y description BINDING SITE FOR RESIDUE RRG A 501 source : AC1 7) chain A residue 330 type sequence L description BINDING SITE FOR RESIDUE RRG A 501 source : AC1 8) chain A residue 341 type sequence I description BINDING SITE FOR RESIDUE RRG A 501 source : AC1 9) chain A residue 342 type sequence S description BINDING SITE FOR RESIDUE RRG A 501 source : AC1 10) chain A residue 363 type sequence F description BINDING SITE FOR RESIDUE RRG A 501 source : AC1 11) chain A residue 364 type sequence M description BINDING SITE FOR RESIDUE RRG A 501 source : AC1 12) chain A residue 367 type sequence K description BINDING SITE FOR RESIDUE RRG A 501 source : AC1 13) chain A residue 282 type sequence F description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 14) chain A residue 283 type sequence Q description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 15) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 16) chain A residue 286 type sequence Q description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 17) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 18) chain A residue 323 type sequence H description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 19) chain A residue 326 type sequence I description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 20) chain A residue 327 type sequence Y description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 21) chain A residue 363 type sequence F description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 22) chain A residue 449 type sequence H description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 23) chain A residue 453 type sequence L description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 24) chain A residue 456 type sequence I description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 25) chain A residue 463 type sequence M description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 26) chain A residue 469 type sequence L description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 27) chain A residue 473 type sequence Y description BINDING SITE FOR RESIDUE RRG A 502 source : AC2 28) chain A residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 29) chain A residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 30) chain A residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 31) chain A residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 32) chain B residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 33) chain B residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 34) chain B residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 35) chain B residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 36) chain A residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2 37) chain B residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

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