eF-site ID 4e45-ABCDEFGHIJKLMNO PDB Code 4e45 Chain A, B, C, D, E, F, G, H, I, J, K, L, M, N, O click to enlarge Title Crystal structure of the hMHF1/hMHF2 Histone-Fold Tetramer in Complex with Fanconi Anemia Associated Helicase hFANCM Classification DNA BINDING PROTEIN/HYDROLASE Compound Centromere protein S Source Homo sapiens (Human) (FANCM_HUMAN) Sequence A:  EAETEEQQRFSYQQRLKAAVHYTVGCLCEEVALDKEMQFS KQTIAAISELTFRQCENFAKDLEMFARHAKRTTINTEDVK LLARRSNSLLKYITDKSEEIAQ B:  SGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVV EAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF C:  RFSYQQRLKAAVHYTVGCLCEEVALDKEMQFSKQTIAAIS ELTFRQCENFAKDLEMFARHAKRTTINTEDVKLLARRSNS LLKYITDKSEEIAQ D:  SGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVV EAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF E:  KDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLTT GIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIE GMRHEEGECSYELEVESYLQMEDVT F:  EAETEEQQRFSYQQRLKAAVHYTVGCLCEEVALDKEMQFS KQTIAAISELTFRQCENFAKDLEMFARHAKRTTINTEDVK LLARRSNSLLKYITDKSEEIAQ G:  SGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVV EAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF H:  RFSYQQRLKAAVHYTVGCLCEEVALDKEMQFSKQTIAAIS ELTFRQCENFAKDLEMFARHAKRTTINTEDVKLLARRSNS LLKYITDKSEEIAQ I:  SGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVV EAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF J:  KDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLTT GIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIE GMRHEEGECSYELEVESYLQMEDVT K:  EQQRFSYQQRLKAAVHYTVGCLCEEVALDKEMQFSKQTIA AISELTFRQCENFAKDLEMFARHAKRTTINTEDVKLLARR SNSLLKYITDKSEE L:  SGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVV EAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF M:  EEQQRFSYQQRLKAAVHYTVGCLCEEVALDKEMQFSKQTI AAISELTFRQCENFAKDLEMFARHAKRTTINTEDVKLLAR RSNSLLKYITDKS N:  SGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVV EAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF O:  KDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLTT GIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIE GMRHECSYELEVESYLQMEDV Description Functional site 1) chain B residue 17 type sequence R description BINDING SITE FOR RESIDUE GOL B 101 source : AC1 2) chain D residue 76 type sequence Q description BINDING SITE FOR RESIDUE ZN D 101 source : AC2 3) chain D residue 80 type sequence D description BINDING SITE FOR RESIDUE ZN D 101 source : AC2 4) chain E residue 751 type sequence H description BINDING SITE FOR RESIDUE ZN D 101 source : AC2 5) chain E residue 755 type sequence C description BINDING SITE FOR RESIDUE ZN D 101 source : AC2 6) chain H residue 32 type sequence E description BINDING SITE FOR RESIDUE GOL H 201 source : AC3 7) chain H residue 42 type sequence F description BINDING SITE FOR RESIDUE GOL H 201 source : AC3 8) chain J residue 691 type sequence L description BINDING SITE FOR RESIDUE GOL H 201 source : AC3 9) chain I residue 76 type sequence Q description BINDING SITE FOR RESIDUE ZN J 901 source : AC4 10) chain I residue 80 type sequence D description BINDING SITE FOR RESIDUE ZN J 901 source : AC4 11) chain J residue 751 type sequence H description BINDING SITE FOR RESIDUE ZN J 901 source : AC4 12) chain J residue 755 type sequence C description BINDING SITE FOR RESIDUE ZN J 901 source : AC4 13) chain N residue 76 type sequence Q description BINDING SITE FOR RESIDUE ZN N 101 source : AC5 14) chain N residue 80 type sequence D description BINDING SITE FOR RESIDUE ZN N 101 source : AC5 15) chain O residue 751 type sequence H description BINDING SITE FOR RESIDUE ZN N 101 source : AC5 16) chain O residue 755 type sequence C description BINDING SITE FOR RESIDUE ZN N 101 source : AC5

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