eF-site ID 4e26-B PDB Code 4e26 Chain B click to enlarge Title BRAF in complex with an organic inhibitor 7898734 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Serine/threonine-protein kinase B-raf Source Homo sapiens (Human) (BRAF_HUMAN) Sequence B:  DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNV TAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAI VTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYL HAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSSGSIL WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSN INNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLK KKRDERPLFPQILASIELLARSLP Description Functional site 1) chain B residue 463 type sequence I description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 2) chain B residue 464 type sequence G description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 3) chain B residue 481 type sequence A description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 4) chain B residue 530 type sequence Q description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 5) chain B residue 531 type sequence W description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 6) chain B residue 532 type sequence C description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 7) chain B residue 535 type sequence S description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 8) chain B residue 536 type sequence S description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 9) chain B residue 539 type sequence H description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 10) chain B residue 583 type sequence F description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 11) chain B residue 671 type MOD_RES sequence R description Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714 source Swiss-Prot : SWS_FT_FI6 12) chain B residue 578 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581 source Swiss-Prot : SWS_FT_FI7 13) chain B residue 576 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 14) chain B residue 463 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 15) chain B residue 483 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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