eF-site ID 4e26-AB PDB Code 4e26 Chain A, B click to enlarge Title BRAF in complex with an organic inhibitor 7898734 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Serine/threonine-protein kinase B-raf Source Homo sapiens (Human) (BRAF_HUMAN) Sequence A:  DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNV TAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAI VTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYL HAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRFEQL SGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQ LPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLM AECLKKKRDERPLFPQILASIELLARSLPK B:  DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNV TAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAI VTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYL HAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSSGSIL WMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSN INNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLK KKRDERPLFPQILASIELLARSLP Description Functional site 1) chain A residue 481 type sequence A description BINDING SITE FOR RESIDUE 734 A 801 source : AC1 2) chain A residue 514 type sequence L description BINDING SITE FOR RESIDUE 734 A 801 source : AC1 3) chain A residue 530 type sequence Q description BINDING SITE FOR RESIDUE 734 A 801 source : AC1 4) chain A residue 531 type sequence W description BINDING SITE FOR RESIDUE 734 A 801 source : AC1 5) chain A residue 532 type sequence C description BINDING SITE FOR RESIDUE 734 A 801 source : AC1 6) chain A residue 536 type sequence S description BINDING SITE FOR RESIDUE 734 A 801 source : AC1 7) chain A residue 583 type sequence F description BINDING SITE FOR RESIDUE 734 A 801 source : AC1 8) chain B residue 463 type sequence I description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 9) chain B residue 464 type sequence G description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 10) chain B residue 481 type sequence A description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 11) chain B residue 530 type sequence Q description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 12) chain B residue 531 type sequence W description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 13) chain B residue 532 type sequence C description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 14) chain B residue 535 type sequence S description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 15) chain B residue 536 type sequence S description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 16) chain B residue 539 type sequence H description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 17) chain B residue 583 type sequence F description BINDING SITE FOR RESIDUE 734 B 801 source : AC2 18) chain A residue 576 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 576 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 463 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 483 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 463 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 23) chain B residue 483 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 463-483 type prosite sequence IGSGSFGTVYKGKWHGDVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGTVYkGkwhgd.............VAVK source prosite : PS00107 25) chain A residue 572-584 type prosite sequence IIHRDLKSNNIFL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKsnNIFL source prosite : PS00108 26) chain A residue 671 type MOD_RES sequence R description Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714 source Swiss-Prot : SWS_FT_FI6 27) chain B residue 671 type MOD_RES sequence R description Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714 source Swiss-Prot : SWS_FT_FI6 28) chain A residue 578 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581 source Swiss-Prot : SWS_FT_FI7 29) chain B residue 578 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581 source Swiss-Prot : SWS_FT_FI7

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