eF-site ID 4e26-A PDB Code 4e26 Chain A click to enlarge Title BRAF in complex with an organic inhibitor 7898734 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Serine/threonine-protein kinase B-raf Source Homo sapiens (Human) (BRAF_HUMAN) Sequence A:  DDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNV TAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAI VTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYL HAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRFEQL SGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQ LPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLM AECLKKKRDERPLFPQILASIELLARSLPK Description Functional site 1) chain A residue 481 type sequence A description BINDING SITE FOR RESIDUE 734 A 801 source : AC1 2) chain A residue 514 type sequence L description BINDING SITE FOR RESIDUE 734 A 801 source : AC1 3) chain A residue 530 type sequence Q description BINDING SITE FOR RESIDUE 734 A 801 source : AC1 4) chain A residue 531 type sequence W description BINDING SITE FOR RESIDUE 734 A 801 source : AC1 5) chain A residue 532 type sequence C description BINDING SITE FOR RESIDUE 734 A 801 source : AC1 6) chain A residue 536 type sequence S description BINDING SITE FOR RESIDUE 734 A 801 source : AC1 7) chain A residue 583 type sequence F description BINDING SITE FOR RESIDUE 734 A 801 source : AC1 8) chain A residue 671 type MOD_RES sequence R description Omega-N-methylarginine; by PRMT5 => ECO:0000269|PubMed:21917714 source Swiss-Prot : SWS_FT_FI6 9) chain A residue 578 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23907581 source Swiss-Prot : SWS_FT_FI7 10) chain A residue 576 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 463 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 12) chain A residue 483 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 463-483 type prosite sequence IGSGSFGTVYKGKWHGDVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGSFGTVYkGkwhgd.............VAVK source prosite : PS00107 14) chain A residue 572-584 type prosite sequence IIHRDLKSNNIFL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHrDLKsnNIFL source prosite : PS00108

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