eF-site ID 4e0s-B PDB Code 4e0s Chain B click to enlarge Title Crystal Structure of C5b-6 Classification IMMUNE SYSTEM Compound Complement C5 Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence B:  CFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFC EQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQS KVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEADCK NKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVCT RKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTV KSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFYKDLTSL GHNENQQGVPIFYSSKRSENINHNSAFKQAIQASHKKDSS FIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSA LYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLT EEEAKHCVRIETKKRVLFAKKTKVEHRCTTNKLSEKHEGS FIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEW LESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQ EYAAKFDPCQCAPCPNNGRPTLSGTECLCVCQSGTYGENC EKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNP APQRGGKRCEGEKRQEEDCTFSIMENNGQPCINDDEEMKE VDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISC LTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEV LTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWT PPISNSLTCEKDTLGHCQLGQKQSGSECICMSPEEDCSHH SEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGS CQDGRQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSAS TSKCVCLLPPQCFKGGNQLYCVKMGSSTSEKTLNICEVGT IRCANRKMEILHPGKCLA Description Functional site 1) chain B residue 8 type CARBOHYD sequence W description C-linked (Man) tryptophan => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 11 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 3) chain B residue 69 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 4) chain B residue 547 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 5) chain B residue 550 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 6) chain B residue 553 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 7) chain B residue 17 type CARBOHYD sequence T description O-linked (Fuc...) threonine => ECO:0000305|PubMed:22267737 source Swiss-Prot : SWS_FT_FI3 8) chain B residue 371 type CARBOHYD sequence T description O-linked (Fuc...) threonine => ECO:0000305|PubMed:22267737 source Swiss-Prot : SWS_FT_FI3 9) chain B residue 303 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:22267737 source Swiss-Prot : SWS_FT_FI4 10) chain B residue 834 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 source Swiss-Prot : SWS_FT_FI5 11) chain B residue 520-531 type prosite sequence CVCQSGTYGENC description EGF_1 EGF-like domain signature 1. CvCqsGtyGEnC source prosite : PS00022 12) chain B residue 333-344 type prosite sequence YSRIFDDFGTHY description MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YsrifddFGTHY source prosite : PS00279 13) chain B residue 130-152 type prosite sequence CIARKLECNGENDCGDNSDERDC description LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIarkle.CNgenDCgdn.SDErd...C source prosite : PS01209

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