eF-site ID 4e0s-AB PDB Code 4e0s Chain A, B click to enlarge Title Crystal Structure of C5b-6 Classification IMMUNE SYSTEM Compound Complement C5 Source ORGANISM_COMMON: human; ORGANISM_SCIENTIFIC: Homo sapiens; Sequence A:  EQTYVISAPKIFRVGASENIVIQVYGYTEAFDATISIKSY PDKKFSYSSGHVHLSSENKFQNSAILTIQPKQLPGGQNPV SYVYLEVVSKHFSKSKRMPITYDNGFLFIHTDKPVYTPDQ SVKVRVYSLNDDLKPAKRETVLTFIDPEGSEVDMVEEIDH IGIISFPDFKIPSNPRYGMWTIKAKYKEDFSTTGTAYFEV KEYVLPHFSVSIEPEYNFIGYKNFKNFEITIKARYFYNKV VTEADVYITFGIREDLKDDQKEMMQTAMQNTMLINGIAQV TFDSETAVKELSYYSLEDLNNKYLYIAVTVIESTGGFSEE AEIPGIKYVLSPYKLNLVATPLFLKPGIPYPIKVQVKDSL DQLVGGVPVTLNAQTIDVNQETSDLDPSKSVTRVDDGVAS FVLNLPSGVTVLEFNVKTDAPDLPEENQAREGYRAIAYSS LSQSYLYIDWTDNHKALLVGEHLNIIVTPKSPYIDKITHY NYLILSKGKIIHFGTREKFSDASYQSINIPVTQNMVPSSR LLVYYIVTGEQTAELVSDSVWLNIEEKCGNQLQVHLSPDA DAYSPGQTVSLNMATGMDSWVALAAVDSAVYGVQRGAKKP LERVFQFLEKSDLGCGAGGGLNNANVFHLAGLTFLTNANA DDSQENDEPCKEILRPRSKPEIRSYFPESWLWEVHLVPRR KQLQFALPDSLTTWEIQGIGISNTGICVADTVKAKVFKDV FLEMNIPYSVVRGEQIQLKGTVYNYRTSGMQFCVKMSAVE GICTSESKCVRQKVEGSSSHLVTFTVLPLEIGLHNINFSL ETWFGKEILVKTLRVVPEGVKRESYSGVTLDPRGIYGTIS RRKEFPYRIPLDLVPKTEIKRILSVKGLLVGEILSAVLSQ EGINILTHLPKGSAEAELMSVVPVFYVFHYLETGNHWNIF HSDPLIEKQKLKKKLKEGMLSIMSYRNADYSYSVWKGGSA STWLTAFALRVLGQVNKYVEQNQNSICNSLLWLVENYQLD NGSFKENSQYQPIKLQGTLPVEARENSLYLTAFTVIGIRK AFDICPLVKIDTALIKADNFLLENTLPAQSTFTLAISAYA LSLGDKTHPQFRSIVSALKREALVKGNPPIYRFWKDNLQH KDSSVPNTGTARMVETTAYALLTSLNLKDINYVNPVIKWL SEEQRYGGGFYSTQDTINAIEGLTEYSLLVKQLRLSMDID VSYKHKGALHNYKMTDKNFLGRPVEVLLNDDLIVSTGFGS GLATVHVTTVVHKTSTSEEVCSFYLKIDTQDIEDYKRIVA CASYKPSREESSSGSSHAVMDISLPTGISANEEDLKALVE GVDQLFTDYQIKDGHVILQLNSIPSSDFLCVRFRIFELFE VGFLSPATFTVYEYHRPDKQCTMFYSTSNIKIQKVCEGAA CKCVEADCGQMQEELDLTISAETRKQTACKPEIAYAYKVS ITSITVENVFVKYKATLLDIYKTGEAVAEKDSEITFIKKV TCTNAELVKGRQYLIMGKEALQIKYNFSFRYIYPLDSLTW IEYWPRDTTCSSCQAFLANLDEFAEDIFLNGC B:  CFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFC EQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQS KVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEADCK NKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVCT RKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTV KSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFYKDLTSL GHNENQQGVPIFYSSKRSENINHNSAFKQAIQASHKKDSS FIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSA LYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLT EEEAKHCVRIETKKRVLFAKKTKVEHRCTTNKLSEKHEGS FIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEW LESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQ EYAAKFDPCQCAPCPNNGRPTLSGTECLCVCQSGTYGENC EKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNP APQRGGKRCEGEKRQEEDCTFSIMENNGQPCINDDEEMKE VDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISC LTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEV LTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWT PPISNSLTCEKDTLGHCQLGQKQSGSECICMSPEEDCSHH SEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGS CQDGRQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSAS TSKCVCLLPPQCFKGGNQLYCVKMGSSTSEKTLNICEVGT IRCANRKMEILHPGKCLA Description Functional site 1) chain B residue 8 type CARBOHYD sequence W description C-linked (Man) tryptophan => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 11 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 3) chain B residue 69 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 4) chain B residue 547 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 5) chain B residue 550 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 6) chain B residue 553 type CARBOHYD sequence W description C-linked (Man) tryptophan; partial => ECO:0000269|PubMed:10551839 source Swiss-Prot : SWS_FT_FI2 7) chain B residue 17 type CARBOHYD sequence T description O-linked (Fuc...) threonine => ECO:0000305|PubMed:22267737 source Swiss-Prot : SWS_FT_FI3 8) chain B residue 371 type CARBOHYD sequence T description O-linked (Fuc...) threonine => ECO:0000305|PubMed:22267737 source Swiss-Prot : SWS_FT_FI3 9) chain B residue 303 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:22267737 source Swiss-Prot : SWS_FT_FI4 10) chain B residue 834 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952 source Swiss-Prot : SWS_FT_FI5 11) chain B residue 520-531 type prosite sequence CVCQSGTYGENC description EGF_1 EGF-like domain signature 1. CvCqsGtyGEnC source prosite : PS00022 12) chain B residue 333-344 type prosite sequence YSRIFDDFGTHY description MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YsrifddFGTHY source prosite : PS00279 13) chain B residue 130-152 type prosite sequence CIARKLECNGENDCGDNSDERDC description LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CIarkle.CNgenDCgdn.SDErd...C source prosite : PS01209

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