eF-site ID 4dyo-A PDB Code 4dyo Chain A click to enlarge Title Crystal Structure of Human Aspartyl Aminopeptidase (DNPEP) in complex with Aspartic acid Hydroxamate Classification HYDROLASE Compound Aspartyl aminopeptidase Source Homo sapiens (Human) (DNPEP_HUMAN) Sequence A:  GKARKEAVQTAAKELLKFVNRSPSPFHAVAECRNRLLQAG FSELKETEKWNIKPESKYFMTRNSSTIIAFAVGGQYVPGN GFSLIGAHTDSPCLRVKRRSRRSQVGFQQVGVETYGGGIW STWFDRDLTLAGRVIVKCPTSGRLEQQLVHVERPILRIPH LAIHLQRNINENFGPNTEMHLVPILATAIQEELEKGTERH HSVLMSLLCAHLGLSPKDIVEMELCLADTQPAVLGGAYDE FIFAPRLDNLHSCFCALQALIDSCAGPGSLATEPHVRMVT LYDNEEVGSESAQGAQSLLTELVLRRISASCQHPTAFEEA IPKSFMISADMAHAVHPNYLDKHEENHRPLFHKGPVIKVN SKQRYASNAVSEALIREVANKVKVPLQDLMVRNDTPCGTT IGPILASRLGLRVLDLGSPQLAMHSIREMACTTGVLQTLT LFKGFFELFPSLAENLY Description Functional site 1) chain A residue 264 type sequence D description BINDING SITE FOR RESIDUE ZN A 501 source : AC1 2) chain A residue 302 type sequence E description BINDING SITE FOR RESIDUE ZN A 501 source : AC1 3) chain A residue 440 type sequence H description BINDING SITE FOR RESIDUE ZN A 501 source : AC1 4) chain A residue 94 type sequence H description BINDING SITE FOR RESIDUE ZN A 502 source : AC2 5) chain A residue 264 type sequence D description BINDING SITE FOR RESIDUE ZN A 502 source : AC2 6) chain A residue 302 type sequence E description BINDING SITE FOR RESIDUE ZN A 502 source : AC2 7) chain A residue 346 type sequence D description BINDING SITE FOR RESIDUE ZN A 502 source : AC2 8) chain A residue 94 type sequence H description BINDING SITE FOR RESIDUE SD4 A 504 source : AC4 9) chain A residue 170 type sequence H description BINDING SITE FOR RESIDUE SD4 A 504 source : AC4 10) chain A residue 264 type sequence D description BINDING SITE FOR RESIDUE SD4 A 504 source : AC4 11) chain A residue 301 type sequence E description BINDING SITE FOR RESIDUE SD4 A 504 source : AC4 12) chain A residue 302 type sequence E description BINDING SITE FOR RESIDUE SD4 A 504 source : AC4 13) chain A residue 346 type sequence D description BINDING SITE FOR RESIDUE SD4 A 504 source : AC4 14) chain A residue 347 type sequence M description BINDING SITE FOR RESIDUE SD4 A 504 source : AC4 15) chain A residue 349 type sequence H description BINDING SITE FOR RESIDUE SD4 A 504 source : AC4 16) chain A residue 374 type sequence K description BINDING SITE FOR RESIDUE SD4 A 504 source : AC4 17) chain A residue 381 type sequence Y description BINDING SITE FOR RESIDUE SD4 A 504 source : AC4 18) chain A residue 414 type sequence G description BINDING SITE FOR RESIDUE SD4 A 504 source : AC4 19) chain A residue 415 type sequence T description BINDING SITE FOR RESIDUE SD4 A 504 source : AC4 20) chain A residue 440 type sequence H description BINDING SITE FOR RESIDUE SD4 A 504 source : AC4 21) chain A residue 67 type sequence T description BINDING SITE FOR RESIDUE GOL A 505 source : AC5 22) chain A residue 68 type sequence R description BINDING SITE FOR RESIDUE GOL A 505 source : AC5 23) chain A residue 69 type sequence N description BINDING SITE FOR RESIDUE GOL A 505 source : AC5 24) chain A residue 70 type sequence S description BINDING SITE FOR RESIDUE GOL A 505 source : AC5 25) chain A residue 428 type sequence R description BINDING SITE FOR RESIDUE GOL A 505 source : AC5 26) chain A residue 353 type sequence P description BINDING SITE FOR RESIDUE GOL A 506 source : AC6 27) chain A residue 354 type sequence N description BINDING SITE FOR RESIDUE GOL A 506 source : AC6 28) chain A residue 355 type sequence Y description BINDING SITE FOR RESIDUE GOL A 506 source : AC6 29) chain A residue 356 type sequence L description BINDING SITE FOR RESIDUE GOL A 506 source : AC6 30) chain A residue 357 type sequence D description BINDING SITE FOR RESIDUE GOL A 506 source : AC6 31) chain A residue 105 type sequence R description BINDING SITE FOR RESIDUE GOL A 507 source : AC7 32) chain A residue 362 type sequence N description BINDING SITE FOR RESIDUE GOL A 507 source : AC7 33) chain A residue 364 type sequence R description BINDING SITE FOR RESIDUE GOL A 507 source : AC7 34) chain A residue 403 type sequence Q description BINDING SITE FOR RESIDUE GOL A 507 source : AC7 35) chain A residue 404 type sequence D description BINDING SITE FOR RESIDUE GOL A 507 source : AC7 36) chain A residue 169 type sequence I description BINDING SITE FOR RESIDUE GOL A 508 source : AC8 37) chain A residue 170 type sequence H description BINDING SITE FOR RESIDUE GOL A 508 source : AC8 38) chain A residue 173 type sequence R description BINDING SITE FOR RESIDUE GOL A 508 source : AC8 39) chain A residue 440 type sequence H description BINDING SITE FOR RESIDUE GOL A 508 source : AC8 40) chain A residue 424 type sequence R description BINDING SITE FOR RESIDUE GOL A 509 source : AC9 41) chain A residue 424 type sequence R description BINDING SITE FOR RESIDUE GOL A 509 source : AC9 42) chain A residue 424 type sequence R description BINDING SITE FOR RESIDUE GOL A 509 source : AC9 43) chain A residue 357 type sequence D description BINDING SITE FOR RESIDUE GOL A 510 source : BC1 44) chain A residue 358 type sequence K description BINDING SITE FOR RESIDUE GOL A 510 source : BC1 45) chain A residue 408 type sequence R description BINDING SITE FOR RESIDUE GOL A 510 source : BC1 46) chain A residue 410 type sequence D description BINDING SITE FOR RESIDUE GOL A 510 source : BC1 47) chain A residue 104 type BINDING sequence R description BINDING => ECO:0000269|PubMed:22720794 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 450 type BINDING sequence G description BINDING => ECO:0000269|PubMed:22720794 source Swiss-Prot : SWS_FT_FI1 49) chain A residue 180 type BINDING sequence G description BINDING => ECO:0000269|PubMed:22720794 source Swiss-Prot : SWS_FT_FI1 50) chain A residue 274 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:22720794 source Swiss-Prot : SWS_FT_FI1 51) chain A residue 311 type BINDING sequence A description BINDING => ECO:0000269|PubMed:22720794 source Swiss-Prot : SWS_FT_FI1 52) chain A residue 312 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:22720794 source Swiss-Prot : SWS_FT_FI1 53) chain A residue 356 type BINDING sequence L description BINDING => ECO:0000269|PubMed:22720794 source Swiss-Prot : SWS_FT_FI1 54) chain A residue 359 type BINDING sequence H description BINDING => ECO:0000269|PubMed:22720794 source Swiss-Prot : SWS_FT_FI1 55) chain A residue 384 type BINDING sequence N description BINDING => ECO:0000269|PubMed:22720794 source Swiss-Prot : SWS_FT_FI1 56) chain A residue 391 type BINDING sequence I description BINDING => ECO:0000269|PubMed:22720794 source Swiss-Prot : SWS_FT_FI1

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