eF-site ID 4dnc-A
PDB Code 4dnc
Chain A

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Title Crystal structure of human MOF in complex with MSL1
Classification TRANSCRIPTION
Compound Histone acetyltransferase KAT8
Source Homo sapiens (Human) (MSL1_HUMAN)
Sequence A:  YVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYM
KYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHK
IYCQNLCLLAKLFLDHXTLYFDVEPFVFYILTEVDRQGAH
IVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSY
ELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFR
GTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICV
TPKLVEEHLKSAQYKKPPITVDSVCLKWAPPK
Description (1)  Histone acetyltransferase KAT8 (E.C.2.3.1.48), Male-specific lethal 1 homolog


Functional site

1) chain A
residue 210
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 501
source : AC1

2) chain A
residue 213
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 501
source : AC1

3) chain A
residue 226
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 501
source : AC1

4) chain A
residue 230
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 501
source : AC1

5) chain A
residue 317
type BINDING
sequence I
description BINDING => ECO:0000269|PubMed:21217699, ECO:0000269|Ref.23
source Swiss-Prot : SWS_FT_FI3

6) chain A
residue 324
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:21217699, ECO:0000269|Ref.23
source Swiss-Prot : SWS_FT_FI3

7) chain A
residue 354
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:21217699, ECO:0000269|Ref.23
source Swiss-Prot : SWS_FT_FI3

8) chain A
residue 363
type BINDING
sequence S
description BINDING => ECO:0000269|PubMed:21217699, ECO:0000269|Ref.23
source Swiss-Prot : SWS_FT_FI3

9) chain A
residue 432
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:21217699, ECO:0000269|Ref.23
source Swiss-Prot : SWS_FT_FI3

10) chain A
residue 207-232
type ZN_FING
sequence LWLCEYCLKYMKYEKSYRFHLGQCQW
description C2HC MYST-type => ECO:0000255|PROSITE-ProRule:PRU01063, ECO:0000269|PubMed:22020126
source Swiss-Prot : SWS_FT_FI1

11) chain A
residue 350
type ACT_SITE
sequence E
description Proton donor/acceptor => ECO:0000303|PubMed:21217699, ECO:0000303|PubMed:22020126, ECO:0000305
source Swiss-Prot : SWS_FT_FI2

12) chain A
residue 274
type MOD_RES
sequence X
description N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:21691301, ECO:0000269|PubMed:22020126, ECO:0000269|PubMed:22547026, ECO:0000269|Ref.23
source Swiss-Prot : SWS_FT_FI4

13) chain A
residue 348
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI5


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