eF-site ID 4deg-A
PDB Code 4deg
Chain A

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Title Crystal structure of c-Met in complex with triazolopyridazine inhibitor 2
Classification TRANSFERASE/TRANSFERASE INHIBITOR
Compound Hepatocyte growth factor receptor
Source Homo sapiens (Human) (MET_HUMAN)
Sequence A:  HIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGC
VYHGTLKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHP
NVLSLLGICLRSPLVVLPYMKHGDLRNFIRNETHNPTVKD
LIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDEKFTVKV
ADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGR
RLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVSRISAI
FSTFIG
Description


Functional site

1) chain A
residue 1084
type
sequence I
description BINDING SITE FOR RESIDUE 0JJ A 1401
source : AC1

2) chain A
residue 1108
type
sequence A
description BINDING SITE FOR RESIDUE 0JJ A 1401
source : AC1

3) chain A
residue 1158
type
sequence P
description BINDING SITE FOR RESIDUE 0JJ A 1401
source : AC1

4) chain A
residue 1160
type
sequence M
description BINDING SITE FOR RESIDUE 0JJ A 1401
source : AC1

5) chain A
residue 1164
type
sequence D
description BINDING SITE FOR RESIDUE 0JJ A 1401
source : AC1

6) chain A
residue 1208
type
sequence R
description BINDING SITE FOR RESIDUE 0JJ A 1401
source : AC1

7) chain A
residue 1211
type
sequence M
description BINDING SITE FOR RESIDUE 0JJ A 1401
source : AC1

8) chain A
residue 1221
type
sequence A
description BINDING SITE FOR RESIDUE 0JJ A 1401
source : AC1

9) chain A
residue 1222
type
sequence D
description BINDING SITE FOR RESIDUE 0JJ A 1401
source : AC1

10) chain A
residue 1226
type
sequence A
description BINDING SITE FOR RESIDUE 0JJ A 1401
source : AC1

11) chain A
residue 1230
type
sequence Y
description BINDING SITE FOR RESIDUE 0JJ A 1401
source : AC1

12) chain A
residue 1289
type MOD_RES
sequence T
description Phosphothreonine => ECO:0007744|PubMed:19369195
source Swiss-Prot : SWS_FT_FI7

13) chain A
residue 1234
type MOD_RES
sequence Y
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12475979
source Swiss-Prot : SWS_FT_FI5

14) chain A
residue 1235
type MOD_RES
sequence Y
description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:12475979, ECO:0000269|PubMed:1655790
source Swiss-Prot : SWS_FT_FI6

15) chain A
residue 1204
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
source Swiss-Prot : SWS_FT_FI1

16) chain A
residue 1084
type BINDING
sequence I
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

17) chain A
residue 1110
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI3

18) chain A
residue 1230
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0000269|PubMed:12475979
source Swiss-Prot : SWS_FT_FI4

19) chain A
residue 1084-1110
type prosite
sequence IGRGHFGCVYHGTLKIHCAVK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGHFGCVYhGtlldndgkkih.......CAVK
source prosite : PS00107

20) chain A
residue 1200-1212
type prosite
sequence FVHRDLAARNCML
description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLAARNCML
source prosite : PS00109


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