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eF-site ID
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4ddi-C |
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PDB Code
|
4ddi |
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Chain
|
C |
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click to enlarge
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Title
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Crystal structure of human OTUB1/UbcH5b~Ub/Ub |
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Classification
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HYDROLASE/LIGASE |
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Compound
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Ubiquitin-conjugating enzyme E2 D2, Ubiquitin thioesterase OTUB1 |
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Source
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Homo sapiens (Human) (UBC_HUMAN) |
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Sequence
|
C: |
GAMALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIM
GPNDSPYQGGVFFLTIHFPTDYPFKPPKVAFTTRIYHPNI
NSNGSISLDILRSQWSPALTISKVLLSICSLLCDPNPDDP
LVPEIARIYKTDREKYNRIAREWTQKYAMGGSAYDEAIMA
QQDRIQQEIAVQNPLVSERLELSVLYKEYAEDDNIYQQKI
KDLHKKYSYIRKTRPDGNSFYRAFGFSHLEALLDDSKELQ
RFKAVSAKSKEDLVSQGFTEFTIEDFHNTFMDLIEQVEKQ
TSVADLLASFNDQSTSDYLVVYLRLLTSGYLQRESKFFEH
FIEGGRTVKEFCQQEVEPMCKESDHIHIIALAQALSVSIQ
VEYMDRGEGGTTNPHIFPEGSEPKVYLLYRPGHYDILYK
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Description
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(1) |
Ubiquitin thioesterase OTUB1 (E.C.6.3.2.19, 3.4.19.12), Ubiquitin-conjugating enzyme E2 D2, Polyubiquitin-C
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Functional site
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|
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1)
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chain |
C |
| residue |
1221 |
| type |
MOD_RES |
| sequence |
I
|
| description |
ADP-ribosylglycine => ECO:0000269|PubMed:28525742
|
| source |
Swiss-Prot : SWS_FT_FI5
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2)
|
chain |
C |
| residue |
1235 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
ADP-ribosylglycine => ECO:0000269|PubMed:28525742
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
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3)
|
chain |
C |
| residue |
1237 |
| type |
MOD_RES |
| sequence |
D
|
| description |
ADP-ribosylglycine => ECO:0000269|PubMed:28525742
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
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4)
|
chain |
C |
| residue |
1261 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
ADP-ribosylglycine => ECO:0000269|PubMed:28525742
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
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5)
|
chain |
C |
| residue |
1026 |
| type |
CROSSLNK |
| sequence |
Y
|
| description |
Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)
|
| source |
Swiss-Prot : SWS_FT_FI7
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