eF-site ID 4dc0-AB PDB Code 4dc0 Chain A, B click to enlarge Title Crystal Structure of F189W Actinorhodin Polyketide Ketoreductase with NADPH Classification OXIDOREDUCTASE Compound Ketoacyl reductase Source Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) (ACT3_STRCO) Sequence A:  QDSEVALVTGATSGIGLEIARRLGKEGLRVFVCARGEEGL RTTLKELREAGVEADGRTCDVRSVPEIEALVAAVVERYGP VDVLVNNAGRPGGGATAELADELWLDVVETNLTGVFRVTK QVLKAGGMLERGTGRIVNIASTGGKQGVVHAAPYSASKHG VVGFTKALGLELARTGITVNAVCPGWVETPMAASVREHYS DIWEVSTEEAFDRITARVPIGRYVQPSEVAEMVAYLIGPG AAAVTAQALNVCGGLGNY B:  MATQDSEVALVTGATSGIGLEIARRLGKEGLRVFVCARGE EGLRTTLKELREAGVEADGRTCDVRSVPEIEALVAAVVER YGPVDVLVNNAGRPGGGATAELADELWLDVVETNLTGVFR VTKQVLKAGGMLERGTGRIVNIASTGGKQGVVHAAPYSAS KHGVVGFTKALGLELARTGITVNAVCPGWVETPMAASVRE HYSDIWEVSTEEAFDRITARVPIGRYVQPSEVAEMVAYLI GPGAAAVTAQALNVCGGLGNY Description Functional site 1) chain A residue 13 type sequence G description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 2) chain A residue 15 type sequence T description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 3) chain A residue 16 type sequence S description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 4) chain A residue 17 type sequence G description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 5) chain A residue 18 type sequence I description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 6) chain A residue 37 type sequence A description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 7) chain A residue 38 type sequence R description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 8) chain A residue 39 type sequence G description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 9) chain A residue 62 type sequence C description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 10) chain A residue 63 type sequence D description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 11) chain A residue 64 type sequence V description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 12) chain A residue 90 type sequence N description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 13) chain A residue 142 type sequence I description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 14) chain A residue 143 type sequence A description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 15) chain A residue 144 type sequence S description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 16) chain A residue 157 type sequence Y description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 17) chain A residue 161 type sequence K description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 18) chain A residue 187 type sequence P description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 19) chain A residue 188 type sequence G description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 20) chain A residue 190 type sequence V description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 21) chain A residue 192 type sequence T description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 22) chain A residue 193 type sequence P description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 23) chain A residue 194 type sequence M description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 24) chain B residue 51 type sequence R description BINDING SITE FOR RESIDUE NDP A 301 source : AC1 25) chain B residue 13 type sequence G description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 26) chain B residue 15 type sequence T description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 27) chain B residue 16 type sequence S description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 28) chain B residue 18 type sequence I description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 29) chain B residue 37 type sequence A description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 30) chain B residue 38 type sequence R description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 31) chain B residue 39 type sequence G description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 32) chain B residue 62 type sequence C description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 33) chain B residue 63 type sequence D description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 34) chain B residue 64 type sequence V description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 35) chain B residue 90 type sequence N description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 36) chain B residue 91 type sequence A description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 37) chain B residue 92 type sequence G description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 38) chain B residue 143 type sequence A description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 39) chain B residue 144 type sequence S description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 40) chain B residue 157 type sequence Y description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 41) chain B residue 161 type sequence K description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 42) chain B residue 187 type sequence P description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 43) chain B residue 188 type sequence G description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 44) chain B residue 190 type sequence V description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 45) chain B residue 192 type sequence T description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 46) chain B residue 193 type sequence P description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 47) chain B residue 194 type sequence M description BINDING SITE FOR RESIDUE NDP B 301 source : AC2 48) chain A residue 157 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 source Swiss-Prot : SWS_FT_FI1 49) chain B residue 157 type ACT_SITE sequence Y description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001 source Swiss-Prot : SWS_FT_FI1 50) chain A residue 11 type BINDING sequence V description BINDING => ECO:0000269|PubMed:15458634, ECO:0000269|PubMed:15544323 source Swiss-Prot : SWS_FT_FI2 51) chain A residue 63 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15458634, ECO:0000269|PubMed:15544323 source Swiss-Prot : SWS_FT_FI2 52) chain A residue 161 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15458634, ECO:0000269|PubMed:15544323 source Swiss-Prot : SWS_FT_FI2 53) chain B residue 11 type BINDING sequence V description BINDING => ECO:0000269|PubMed:15458634, ECO:0000269|PubMed:15544323 source Swiss-Prot : SWS_FT_FI2 54) chain B residue 63 type BINDING sequence D description BINDING => ECO:0000269|PubMed:15458634, ECO:0000269|PubMed:15544323 source Swiss-Prot : SWS_FT_FI2 55) chain B residue 161 type BINDING sequence K description BINDING => ECO:0000269|PubMed:15458634, ECO:0000269|PubMed:15544323 source Swiss-Prot : SWS_FT_FI2 56) chain A residue 144 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 57) chain B residue 144 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 58) chain A residue 144-172 type prosite sequence STGGKQGVVHAAPYSASKHGVVGFTKALG description ADH_SHORT Short-chain dehydrogenases/reductases family signature. StggkqgvvhAapYSASKHGVvGFTkALG source prosite : PS00061

Display surface Download Links