eF-site ID 4da4-A PDB Code 4da4 Chain A click to enlarge Title Structure of mouse DNMT1 (731-1602) bound to hemimethylated CpG DNA Classification Transferase/DNA Compound DNA (cytosine-5)-methyltransferase 1 Source Mus musculus (Mouse) (4DA4) Sequence A:  DRISWLGQPMKIEENRTYYQKVSIDEEMLEVGDCVSVIPD DSSKPLYLARVTALWEDKNGQMMFHAHWFCAGTDTVLGAT SDPLELFLVGECENMQLSYIHSKVKVIYKAPSENWAMEGG EDGKTYFFQLWYNQEYARFESPPKTQPTEDNKHKFCLSCI RLAELRQKEMPKVLEQIEEVDGRVYCSSITKNGVVYRLGD SVYLPPEAFTFNIKVASPVKRPKKDPVNETLYPEHYRKYS DYIKGSNLDAPEPYRIGRIKEIHCGKKKGKVNEADIKLRL YKFYRPENTHRSYNGSYHTDINMLYWSDEEAVVNFSDVQG RCTVEYGEDLLESIQDYSQGGPDRFYFLEAYNSKTKNFED PPNHARSPGNIKLPKLRTLDVFSGCGGLSEGFHQAGISET LWAIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKLVMAGEV TNSLGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKF KNSLVVSFLSYCDYYRPRFFLLENVRNFVSYRRSMVLKLT LRCLVRMGYQCTFGVLQAGQYGVAQTRRRAIILAAAPGEK LPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFR TITVRDTMSDLPEIQNGASNSEIPYNGEPLSWFQRQLRGS HYQPILRDHICKDMSPLVAARMRHIPLFPGSDWRDLPNIQ VRLGDGVIAHKLQYTFHDVKNGYSSTGALRGVCSCAEGKA CDPESRQFSTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFS TTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDSYR FFGNILDRHRQVGNAVPPPLAKAIGLEIKLCLLS Description Functional site 1) chain A residue 1148 type sequence F description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 2) chain A residue 1149 type sequence S description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 3) chain A residue 1150 type sequence G description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 4) chain A residue 1152 type sequence G description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 5) chain A residue 1153 type sequence G description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 6) chain A residue 1154 type sequence L description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 7) chain A residue 1171 type sequence E description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 8) chain A residue 1172 type sequence M description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 9) chain A residue 1173 type sequence W description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 10) chain A residue 1193 type sequence D description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 11) chain A residue 1194 type sequence C description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 12) chain A residue 1226 type sequence G description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 13) chain A residue 1247 type sequence K description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 14) chain A residue 1250 type sequence L description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 15) chain A residue 1581 type sequence A description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 16) chain A residue 1582 type sequence V description BINDING SITE FOR RESIDUE SAH A 1701 source : AC1 17) chain A residue 1479 type sequence C description BINDING SITE FOR RESIDUE ZN A 1702 source : AC2 18) chain A residue 1481 type sequence C description BINDING SITE FOR RESIDUE ZN A 1702 source : AC2 19) chain A residue 1487 type sequence C description BINDING SITE FOR RESIDUE ZN A 1702 source : AC2 20) chain A residue 1504 type sequence H description BINDING SITE FOR RESIDUE ZN A 1702 source : AC2 21) chain A residue 796 type sequence H description BINDING SITE FOR RESIDUE ZN A 1703 source : AC3 22) chain A residue 823 type sequence C description BINDING SITE FOR RESIDUE ZN A 1703 source : AC3 23) chain A residue 897 type sequence C description BINDING SITE FOR RESIDUE ZN A 1703 source : AC3 24) chain A residue 900 type sequence C description BINDING SITE FOR RESIDUE ZN A 1703 source : AC3 25) chain A residue 1566 type sequence R description BINDING SITE FOR RESIDUE CIT B 1704 source : AC7 26) chain A residue 1568 type sequence F description BINDING SITE FOR RESIDUE CIT B 1704 source : AC7 27) chain A residue 1569 type sequence G description BINDING SITE FOR RESIDUE CIT B 1704 source : AC7 28) chain A residue 1574 type sequence R description BINDING SITE FOR RESIDUE CIT B 1704 source : AC7 29) chain A residue 1149 type BINDING sequence S description BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PT6, ECO:0007744|PDB:4DA4 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 1229 type ACT_SITE sequence C description ACT_SITE => ECO:0000269|PubMed:17576694 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 735 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P26358 source Swiss-Prot : SWS_FT_FI5 32) chain A residue 882 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P26358 source Swiss-Prot : SWS_FT_FI5 33) chain A residue 1221-1233 type prosite sequence EMLCGGPPCQGFS description C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. EmLcgGpPCqGFS source prosite : PS00094 34) chain A residue 1576-1594 type prosite sequence RQVGNAVPPPLAKAIGLEI description C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RqvGNAVpPpLakaIgleI source prosite : PS00095 35) chain A residue 1153 type BINDING sequence G description BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PT6, ECO:0007744|PDB:3PT9, ECO:0007744|PDB:4DA4 source Swiss-Prot : SWS_FT_FI3 36) chain A residue 1171 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PT6, ECO:0007744|PDB:3PT9, ECO:0007744|PDB:4DA4 source Swiss-Prot : SWS_FT_FI3 37) chain A residue 1582 type BINDING sequence V description BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PT6, ECO:0007744|PDB:3PT9, ECO:0007744|PDB:4DA4 source Swiss-Prot : SWS_FT_FI3 38) chain A residue 1193 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PT6, ECO:0007744|PDB:3PT9 source Swiss-Prot : SWS_FT_FI4 39) chain A residue 752 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P26358 source Swiss-Prot : SWS_FT_FI6 40) chain A residue 1352 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P26358 source Swiss-Prot : SWS_FT_FI6 41) chain A residue 1418 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P26358 source Swiss-Prot : SWS_FT_FI6 42) chain A residue 895 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P26358 source Swiss-Prot : SWS_FT_FI6 43) chain A residue 961 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P26358 source Swiss-Prot : SWS_FT_FI6 44) chain A residue 965 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P26358 source Swiss-Prot : SWS_FT_FI6 45) chain A residue 979 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P26358 source Swiss-Prot : SWS_FT_FI6

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