eF-site ID 4d60-ABCDEFGHIJKLMNOP PDB Code 4d60 Chain A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P click to enlarge Title Structure of a dimeric Plasmodium falciparum profilin mutant Classification STRUCTURAL PROTEIN Compound PROFILIN Source Plasmodium falciparum (isolate HB3) (PROF_PLAFX) Sequence A:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S B:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S C:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S D:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S E:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S F:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S G:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S H:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S I:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S J:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S K:  YSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEES DPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGYA PDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGLH LVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAESS L:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S M:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S N:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S O:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S P:  EYSWDSYLNDRLLATNQVSGAGLASEEDGVVYACVAQGEE SDPNFDKWSLFYKEDYDIEVKTTKTINEGQTILVVFNEGY APDGVWLGGTKYQFINIERDLEFEGYNFDVATCAKLKGGL HLVKVPGGNILVVLYDEEKEQDRGNSKIAALTFAKELAES S Description Functional site 1) chain A residue 81 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1165 source : AC1 2) chain A residue 82 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1165 source : AC1 3) chain A residue 102 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1165 source : AC1 4) chain A residue 99 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1166 source : AC2 5) chain A residue 101 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1166 source : AC2 6) chain A residue 150 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1166 source : AC2 7) chain D residue 146 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1166 source : AC2 8) chain D residue 150 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1166 source : AC2 9) chain B residue 50 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1165 source : AC3 10) chain B residue 99 type sequence N description BINDING SITE FOR RESIDUE SO4 B 1166 source : AC4 11) chain B residue 101 type sequence E description BINDING SITE FOR RESIDUE SO4 B 1166 source : AC4 12) chain B residue 146 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1166 source : AC4 13) chain B residue 150 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1166 source : AC4 14) chain E residue 146 type sequence R description BINDING SITE FOR RESIDUE SO4 B 1166 source : AC4 15) chain E residue 150 type sequence K description BINDING SITE FOR RESIDUE SO4 B 1166 source : AC4 16) chain C residue 101 type sequence E description BINDING SITE FOR RESIDUE SO4 C 1165 source : AC5 17) chain C residue 150 type sequence K description BINDING SITE FOR RESIDUE SO4 C 1165 source : AC5 18) chain I residue 101 type sequence E description BINDING SITE FOR RESIDUE SO4 C 1165 source : AC5 19) chain I residue 150 type sequence K description BINDING SITE FOR RESIDUE SO4 C 1165 source : AC5 20) chain K residue 101 type sequence E description BINDING SITE FOR RESIDUE SO4 N 1165 source : AC6 21) chain K residue 146 type sequence R description BINDING SITE FOR RESIDUE SO4 N 1165 source : AC6 22) chain N residue 99 type sequence N description BINDING SITE FOR RESIDUE SO4 N 1165 source : AC6 23) chain N residue 146 type sequence R description BINDING SITE FOR RESIDUE SO4 N 1165 source : AC6 24) chain N residue 150 type sequence K description BINDING SITE FOR RESIDUE SO4 N 1165 source : AC6 25) chain J residue 101 type sequence E description BINDING SITE FOR RESIDUE SO4 L 1165 source : AC7 26) chain J residue 150 type sequence K description BINDING SITE FOR RESIDUE SO4 L 1165 source : AC7 27) chain L residue 101 type sequence E description BINDING SITE FOR RESIDUE SO4 L 1165 source : AC7 28) chain L residue 146 type sequence R description BINDING SITE FOR RESIDUE SO4 L 1165 source : AC7 29) chain L residue 150 type sequence K description BINDING SITE FOR RESIDUE SO4 L 1165 source : AC7 30) chain C residue 80 type sequence N description BINDING SITE FOR RESIDUE SO4 K 1165 source : AC8 31) chain C residue 81 type sequence E description BINDING SITE FOR RESIDUE SO4 K 1165 source : AC8 32) chain K residue 80 type sequence N description BINDING SITE FOR RESIDUE SO4 K 1165 source : AC8 33) chain K residue 81 type sequence E description BINDING SITE FOR RESIDUE SO4 K 1165 source : AC8 34) chain A residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 35) chain J residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 36) chain K residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 37) chain L residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 38) chain M residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 39) chain N residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 40) chain O residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 41) chain P residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 42) chain B residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 43) chain C residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 44) chain D residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 45) chain E residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 46) chain F residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 47) chain G residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 48) chain H residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 49) chain I residue 35 type SITE sequence Y description Interaction with Pro-rich sequence => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 50) chain A residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 51) chain J residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 52) chain K residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 53) chain L residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 54) chain M residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 55) chain N residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 56) chain O residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 57) chain P residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 58) chain B residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 59) chain C residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 60) chain D residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 61) chain E residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 62) chain F residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 63) chain G residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 64) chain H residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 65) chain I residue 89 type SITE sequence W description Interaction with actin => ECO:0000255 source Swiss-Prot : SWS_FT_FI2

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