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eF-site ID
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4d5n-AX |
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PDB Code
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4d5n |
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Chain
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A, X |
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click to enlarge
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Title
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Cryo-EM structures of ribosomal 80S complexes with termination factors and cricket paralysis virus IRES reveal the IRES in the translocated state |
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Classification
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RIBOSOME/RNA |
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Compound
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EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1 |
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Source
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Homo sapiens (Human) (4D5N) |
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Sequence
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A: |
PSAADRNVEIWKIKKLIKSLEAARGNGTSMISLIIPPKDQ
ISRVAKMLADEFGTASNIKSRVNRLSVLGAITSVQQRLKL
YNKVPPNGLVVYCGTIVTEEGKEKKVNIDFEPFKPINTSL
YLCDNKFHTEALTALLSDDSKFGFIVIDGSGALFGTLQGN
TREVLHKFTVDLPKKHGRGGQSALRFARLRMEKRHNYVRK
VAETAVQLFISGDKVNVAGLVLAGSADFKTELSQSDMFDQ
RLQSKVLKLVDISYGGENGFNQAIELSTEVLSNVKFIQEK
KLIGRYFDEISQDTGKYCFGVEDTLKALEMGAVEILIVYE
NLDIMRYVLHCQGTEEEKILYLTPEQEKDKSHFTDKETGQ
EHELIESMPLLEWFANNYKKFGATLEIVTDKSQEGSQFVK
GFGGIGGILRYRVDFQGMEYQGGDDEFFDLDDYLEH
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| X: |
AAAAAUGUGAUCUUGCUUGUAAAUACAAUUUUGAGAGGUU
AAUAAAUUACAAGUAGUGCUAUUUUUGUAUUUAGGUUAGC
UAUUUAGCUUUACGUUCCAGGAUGCCUAGUGGCAGCCCCA
CAAUAUCCAGGAAGCCCUCUCUGCGGUUAUUCAGAUUAGG
UAGUCGAAAAACCUAAGAAAUUUACCUUAAGGCUUCCUCG
A
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Description
|
(1) |
EUKARYOTIC PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1
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Functional site
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1)
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chain |
A |
| residue |
279 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:37651229
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| source |
Swiss-Prot : SWS_FT_FI5
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2)
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chain |
A |
| residue |
63 |
| type |
MOD_RES |
| sequence |
K
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| description |
4-hydroxylysine => ECO:0000269|PubMed:24486019
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| source |
Swiss-Prot : SWS_FT_FI1
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3)
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chain |
A |
| residue |
185 |
| type |
MOD_RES |
| sequence |
Q
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| description |
N5-methylglutamine => ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:20606008, ECO:0000269|PubMed:26797129
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| source |
Swiss-Prot : SWS_FT_FI2
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4)
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chain |
A |
| residue |
347 |
| type |
MOD_RES |
| sequence |
T
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| description |
Phosphothreonine => ECO:0007744|PubMed:23186163
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| source |
Swiss-Prot : SWS_FT_FI3
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|
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5)
|
chain |
A |
| residue |
404 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
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| source |
Swiss-Prot : SWS_FT_FI4
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6)
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chain |
A |
| residue |
87 |
| type |
CROSSLNK |
| sequence |
K
|
| description |
Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
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| source |
Swiss-Prot : SWS_FT_FI4
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