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eF-site ID
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4d3c-AHL |
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PDB Code
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4d3c |
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Chain
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A, H, L |
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click to enlarge
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Title
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Crystal structure of the NK1 domain of HGF in complex with anti-HGF monoclonal antibody SFN68. |
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Classification
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PROTEIN BINDING |
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Compound
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HEPATOCYTE GROWTH FACTOR |
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Source
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ORGANISM_COMMON: RABBIT; ORGANISM_SCIENTIFIC: ORYCTOLAGUS CUNICULUS; |
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Sequence
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A: |
NTIHEFKKSAKTADQCANRCTRNKGLPFTCKAFVFCLWFP
FNSMSDLYENKDYIRNCIIGKGGSYKGTVSITKSGIKCQP
WSSMIPHEHSFLPSSYRGKDLQENYCRNPRGEEGGPWCFT
SNPEVRYEVCDIPQCSE
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| H: |
QQQLVESGGRLVNPGESLTLTCKASGFTFSTYYMSWVRQA
PGKGLEWIGYIGTSSGTTYYANSVKGRFTISSDNAQNTVF
LQMTSLTDSDTATYFCARGLGRINLWGPGTLVTVSSASTK
GPSVFPLAPCSTAALGCLVKDYFPEPVTVSWNSGALTSGV
HTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPS
NTKVDKRVES
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| L: |
ELDLTQTPSSVSAAVGGTVTINCQASQSVSNLLAWYQQKP
GQPPKLLIYGASNLESGVPSRFRGSGSGTEFTLTISGMKA
EDAATYYCQSGYYSAGATFGAGTNVEIKRTVAAPSVFIFP
PSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS
QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQ
GLSSPVTKS
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Description
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Functional site
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|
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1)
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chain |
A |
| residue |
176-189 |
| type |
prosite |
| sequence |
YCRNPRGEEGGPWC
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| description |
KRINGLE_1 Kringle domain signature. YCRNprgeeggpWC
|
| source |
prosite : PS00021
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|
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2)
|
chain |
L |
| residue |
193-199 |
| type |
prosite |
| sequence |
YACEVTH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
|
| source |
prosite : PS00290
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3)
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chain |
H |
| residue |
197-203 |
| type |
prosite |
| sequence |
YTCNVDH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
|
| source |
prosite : PS00290
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