eF-site ID 4d33-AB PDB Code 4d33 Chain A, B click to enlarge Title Structure of bovine endothelial nitric oxide synthase heme domain in complex with (N1-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)-N2-(3- fluorophenethyl)ethane-1,2-diamine Classification OXIDOREDUCTASE Compound NITRIC OXIDE SYNTHASE, ENDOTHELIAL Source Bos taurus (Bovine) (NOS3_BOVIN) Sequence A:  GPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLV LPRPAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEA EVASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQV FDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRA PGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCI QHGWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPL EHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSG WYMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWK DKAAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQ KARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRY QPDPW B:  KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLP RKPAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAE VASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVF DARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAP GRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQ HGWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLE HPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGW YMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKD KAAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQK ARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQ PDPW Description (1)  NITRIC OXIDE SYNTHASE, ENDOTHELIAL (E.C.1.14.13.39) Functional site 1) chain A residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 2) chain A residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 3) chain A residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 4) chain A residue 187 type sequence V description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 5) chain A residue 188 type sequence G description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 6) chain A residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 7) chain A residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 8) chain A residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 9) chain A residue 357 type sequence G description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 10) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 11) chain A residue 360 type sequence M description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 12) chain A residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 13) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 14) chain A residue 475 type sequence F description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 15) chain A residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 16) chain A residue 104 type sequence S description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 17) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 18) chain A residue 448 type sequence A description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 19) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 20) chain B residue 447 type sequence W description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 21) chain B residue 462 type sequence F description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 22) chain B residue 463 type sequence H description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 23) chain B residue 464 type sequence Q description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 24) chain B residue 465 type sequence E description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 25) chain A residue 107 type sequence L description BINDING SITE FOR RESIDUE 6J0 A 800 source : AC3 26) chain A residue 249 type sequence Q description BINDING SITE FOR RESIDUE 6J0 A 800 source : AC3 27) chain A residue 336 type sequence P description BINDING SITE FOR RESIDUE 6J0 A 800 source : AC3 28) chain A residue 338 type sequence V description BINDING SITE FOR RESIDUE 6J0 A 800 source : AC3 29) chain A residue 357 type sequence G description BINDING SITE FOR RESIDUE 6J0 A 800 source : AC3 30) chain A residue 477 type sequence Y description BINDING SITE FOR RESIDUE 6J0 A 800 source : AC3 31) chain B residue 76 type sequence W description BINDING SITE FOR RESIDUE 6J0 A 800 source : AC3 32) chain A residue 188 type sequence G description BINDING SITE FOR RESIDUE ACT A 860 source : AC4 33) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT A 860 source : AC4 34) chain A residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT A 860 source : AC4 35) chain A residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT A 860 source : AC4 36) chain A residue 248 type sequence S description BINDING SITE FOR RESIDUE MTL A 870 source : AC5 37) chain A residue 252 type sequence R description BINDING SITE FOR RESIDUE MTL A 870 source : AC5 38) chain A residue 268 type sequence A description BINDING SITE FOR RESIDUE MTL A 870 source : AC5 39) chain A residue 269 type sequence N description BINDING SITE FOR RESIDUE MTL A 870 source : AC5 40) chain A residue 271 type sequence E description BINDING SITE FOR RESIDUE MTL A 870 source : AC5 41) chain A residue 272 type sequence I description BINDING SITE FOR RESIDUE MTL A 870 source : AC5 42) chain A residue 340 type sequence N description BINDING SITE FOR RESIDUE MTL A 870 source : AC5 43) chain A residue 480 type sequence D description BINDING SITE FOR RESIDUE MTL A 870 source : AC5 44) chain A residue 106 type sequence V description BINDING SITE FOR RESIDUE GOL A 880 source : AC6 45) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL A 880 source : AC6 46) chain A residue 373 type sequence H description BINDING SITE FOR RESIDUE GOL A 880 source : AC6 47) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL A 880 source : AC6 48) chain B residue 76 type sequence W description BINDING SITE FOR RESIDUE GOL A 880 source : AC6 49) chain A residue 85 type sequence T description BINDING SITE FOR RESIDUE BME A 960 source : AC7 50) chain A residue 324 type sequence W description BINDING SITE FOR RESIDUE BME A 960 source : AC7 51) chain A residue 328 type sequence L description BINDING SITE FOR RESIDUE BME A 960 source : AC7 52) chain A residue 384 type sequence C description BINDING SITE FOR RESIDUE BME A 960 source : AC7 53) chain A residue 440 type sequence R description BINDING SITE FOR RESIDUE BME A 960 source : AC7 54) chain A residue 441 type sequence G description BINDING SITE FOR RESIDUE BME A 960 source : AC7 55) chain B residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 56) chain B residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 57) chain B residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 58) chain B residue 187 type sequence V description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 59) chain B residue 188 type sequence G description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 60) chain B residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 61) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 62) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 63) chain B residue 357 type sequence G description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 64) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 65) chain B residue 360 type sequence M description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 66) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 67) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 68) chain B residue 475 type sequence F description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 69) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM B 500 source : AC8 70) chain A residue 447 type sequence W description BINDING SITE FOR RESIDUE H4B B 600 source : AC9 71) chain A residue 462 type sequence F description BINDING SITE FOR RESIDUE H4B B 600 source : AC9 72) chain A residue 465 type sequence E description BINDING SITE FOR RESIDUE H4B B 600 source : AC9 73) chain B residue 104 type sequence S description BINDING SITE FOR RESIDUE H4B B 600 source : AC9 74) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE H4B B 600 source : AC9 75) chain B residue 448 type sequence A description BINDING SITE FOR RESIDUE H4B B 600 source : AC9 76) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE H4B B 600 source : AC9 77) chain A residue 76 type sequence W description BINDING SITE FOR RESIDUE 6J0 B 800 source : BC1 78) chain B residue 107 type sequence L description BINDING SITE FOR RESIDUE 6J0 B 800 source : BC1 79) chain B residue 249 type sequence Q description BINDING SITE FOR RESIDUE 6J0 B 800 source : BC1 80) chain B residue 336 type sequence P description BINDING SITE FOR RESIDUE 6J0 B 800 source : BC1 81) chain B residue 337 type sequence A description BINDING SITE FOR RESIDUE 6J0 B 800 source : BC1 82) chain B residue 338 type sequence V description BINDING SITE FOR RESIDUE 6J0 B 800 source : BC1 83) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE 6J0 B 800 source : BC1 84) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT B 860 source : BC2 85) chain B residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT B 860 source : BC2 86) chain B residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT B 860 source : BC2 87) chain B residue 248 type sequence S description BINDING SITE FOR RESIDUE MTL B 870 source : BC3 88) chain B residue 252 type sequence R description BINDING SITE FOR RESIDUE MTL B 870 source : BC3 89) chain B residue 268 type sequence A description BINDING SITE FOR RESIDUE MTL B 870 source : BC3 90) chain B residue 269 type sequence N description BINDING SITE FOR RESIDUE MTL B 870 source : BC3 91) chain B residue 271 type sequence E description BINDING SITE FOR RESIDUE MTL B 870 source : BC3 92) chain B residue 272 type sequence I description BINDING SITE FOR RESIDUE MTL B 870 source : BC3 93) chain B residue 340 type sequence N description BINDING SITE FOR RESIDUE MTL B 870 source : BC3 94) chain B residue 480 type sequence D description BINDING SITE FOR RESIDUE MTL B 870 source : BC3 95) chain A residue 76 type sequence W description BINDING SITE FOR RESIDUE GOL B 880 source : BC4 96) chain B residue 106 type sequence V description BINDING SITE FOR RESIDUE GOL B 880 source : BC4 97) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL B 880 source : BC4 98) chain B residue 373 type sequence H description BINDING SITE FOR RESIDUE GOL B 880 source : BC4 99) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL B 880 source : BC4 100) chain A residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : BC5 101) chain A residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : BC5 102) chain B residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : BC5 103) chain B residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : BC5 104) chain A residue 104 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 105) chain A residue 477 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 106) chain B residue 104 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 107) chain B residue 249 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 108) chain B residue 358 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 109) chain B residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 110) chain B residue 363 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 111) chain B residue 368 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 112) chain B residue 448 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 113) chain B residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 114) chain B residue 462 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 115) chain A residue 249 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 116) chain B residue 477 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 117) chain A residue 358 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 118) chain A residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 119) chain A residue 363 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 120) chain A residue 368 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 121) chain A residue 448 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 122) chain A residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 123) chain A residue 462 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 124) chain A residue 186 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 125) chain B residue 186 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 126) chain A residue 185-192 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001 127) chain A residue 96 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 128) chain A residue 101 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 129) chain B residue 96 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 130) chain B residue 101 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1

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