eF-site ID 4cws-A
PDB Code 4cws
Chain A

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Title Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor
Classification CHAPERONE
Compound HEAT SHOCK PROTEIN HSP 90-ALPHA
Source Homo sapiens (Human) (HS90A_HUMAN)
Sequence A:  VETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDAL
DKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTGI
GMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFGV
GFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTDT
GEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIGY
PITLFVE
Description (1)  HEAT SHOCK PROTEIN HSP 90-ALPHA


Functional site

1) chain A
residue 51
type
sequence N
description BINDING SITE FOR RESIDUE G3R A 1224
source : AC1

2) chain A
residue 55
type
sequence A
description BINDING SITE FOR RESIDUE G3R A 1224
source : AC1

3) chain A
residue 58
type
sequence K
description BINDING SITE FOR RESIDUE G3R A 1224
source : AC1

4) chain A
residue 61
type
sequence Y
description BINDING SITE FOR RESIDUE G3R A 1224
source : AC1

5) chain A
residue 93
type
sequence D
description BINDING SITE FOR RESIDUE G3R A 1224
source : AC1

6) chain A
residue 96
type
sequence I
description BINDING SITE FOR RESIDUE G3R A 1224
source : AC1

7) chain A
residue 97
type
sequence G
description BINDING SITE FOR RESIDUE G3R A 1224
source : AC1

8) chain A
residue 98
type
sequence M
description BINDING SITE FOR RESIDUE G3R A 1224
source : AC1

9) chain A
residue 102
type
sequence D
description BINDING SITE FOR RESIDUE G3R A 1224
source : AC1

10) chain A
residue 107
type
sequence L
description BINDING SITE FOR RESIDUE G3R A 1224
source : AC1

11) chain A
residue 138
type
sequence F
description BINDING SITE FOR RESIDUE G3R A 1224
source : AC1

12) chain A
residue 150
type
sequence V
description BINDING SITE FOR RESIDUE G3R A 1224
source : AC1

13) chain A
residue 162
type
sequence W
description BINDING SITE FOR RESIDUE G3R A 1224
source : AC1

14) chain A
residue 38-47
type prosite
sequence YSNKEIFLRE
description HSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE
source prosite : PS00298

15) chain A
residue 51
type BINDING
sequence N
description
source Swiss-Prot : SWS_FT_FI1

16) chain A
residue 93
type BINDING
sequence D
description
source Swiss-Prot : SWS_FT_FI1

17) chain A
residue 138
type BINDING
sequence F
description
source Swiss-Prot : SWS_FT_FI1

18) chain A
residue 112
type BINDING
sequence K
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

19) chain A
residue 58
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000250|UniProtKB:P07901
source Swiss-Prot : SWS_FT_FI3

20) chain A
residue 84
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0000250|UniProtKB:P07901
source Swiss-Prot : SWS_FT_FI3


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