eF-site ID 4cwf-A PDB Code 4cwf Chain A click to enlarge Title Human HSP90 alpha N-terminal domain in complex with an Aminotriazoloquinazoline inhibitor Classification CHAPERONE Compound HEAT SHOCK PROTEIN HSP 90-ALPHA Source Homo sapiens (Human) (HS90A_HUMAN) Sequence A:  EVETFAFQAEIAQLMSLIINTFYSNKEIFLRELISNSSDA LDKIRYESLTDPSKLDSGKELHINLIPNKQDRTLTIVDTG IGMTKADLINNLGTIAKSGTKAFMEALQAGADISMIGQFG VGFYSAYLVAEKVTVITKHNDDEQYAWESSAGGSFTVRTD TGEPMGRGTKVILHLKEDQTEYLEERRIKEIVKKHSQFIG YPITLFVE Description (1)  HEAT SHOCK PROTEIN HSP 90-ALPHA Functional site 1) chain A residue 51 type sequence N description BINDING SITE FOR RESIDUE H05 A 1224 source : AC1 2) chain A residue 111 type sequence A description BINDING SITE FOR RESIDUE H05 A 1224 source : AC1 3) chain A residue 135 type sequence G description BINDING SITE FOR RESIDUE H05 A 1224 source : AC1 4) chain A residue 138 type sequence F description BINDING SITE FOR RESIDUE H05 A 1224 source : AC1 5) chain A residue 139 type sequence Y description BINDING SITE FOR RESIDUE H05 A 1224 source : AC1 6) chain A residue 162 type sequence W description BINDING SITE FOR RESIDUE H05 A 1224 source : AC1 7) chain A residue 51 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI1 8) chain A residue 93 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 9) chain A residue 138 type BINDING sequence F description source Swiss-Prot : SWS_FT_FI1 10) chain A residue 112 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 11) chain A residue 58 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P07901 source Swiss-Prot : SWS_FT_FI3 12) chain A residue 84 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P07901 source Swiss-Prot : SWS_FT_FI3 13) chain A residue 38-47 type prosite sequence YSNKEIFLRE description HSP90 Heat shock hsp90 proteins family signature. YsNKEIFLRE source prosite : PS00298

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