eF-site ID 4cu1-B PDB Code 4cu1 Chain B click to enlarge Title Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-[(2S)-3-amino-2-{5-[2-(6-amino-4-methylpyridin-2-yl)ethyl]pyridin-3-yl}propyl]-4-methylpyridin-2-amine Classification OXIDOREDUCTASE Compound NITRIC OXIDE SYNTHASE, ENDOTHELIAL Source Bos taurus (Bovine) (NOS3_BOVIN) Sequence B:  KFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLVLP RKPAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEAE VASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQVF DARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRAP GRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQ HGWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPLE HPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSGW YMSTEIGTRNLCDPHRYNILEDVAVCMDLDTRTTSSLWKD KAAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQK ARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRYQ PDPW Description (1)  NITRIC OXIDE SYNTHASE, ENDOTHELIAL (E.C.1.14.13.39) Functional site 1) chain B residue 447 type sequence W description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 2) chain B residue 462 type sequence F description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 3) chain B residue 463 type sequence H description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 4) chain B residue 464 type sequence Q description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 5) chain B residue 465 type sequence E description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 6) chain B residue 76 type sequence W description BINDING SITE FOR RESIDUE GOL A 880 source : AC5 7) chain B residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 8) chain B residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 9) chain B residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 10) chain B residue 187 type sequence V description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 11) chain B residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 12) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 13) chain B residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 14) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 15) chain B residue 360 type sequence M description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 16) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 17) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 18) chain B residue 475 type sequence F description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 19) chain B residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM B 500 source : AC6 20) chain B residue 104 type sequence S description BINDING SITE FOR RESIDUE H4B B 600 source : AC7 21) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE H4B B 600 source : AC7 22) chain B residue 448 type sequence A description BINDING SITE FOR RESIDUE H4B B 600 source : AC7 23) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE H4B B 600 source : AC7 24) chain B residue 107 type sequence L description BINDING SITE FOR RESIDUE 71S B 800 source : AC8 25) chain B residue 248 type sequence S description BINDING SITE FOR RESIDUE 71S B 800 source : AC8 26) chain B residue 249 type sequence Q description BINDING SITE FOR RESIDUE 71S B 800 source : AC8 27) chain B residue 336 type sequence P description BINDING SITE FOR RESIDUE 71S B 800 source : AC8 28) chain B residue 338 type sequence V description BINDING SITE FOR RESIDUE 71S B 800 source : AC8 29) chain B residue 340 type sequence N description BINDING SITE FOR RESIDUE 71S B 800 source : AC8 30) chain B residue 355 type sequence F description BINDING SITE FOR RESIDUE 71S B 800 source : AC8 31) chain B residue 357 type sequence G description BINDING SITE FOR RESIDUE 71S B 800 source : AC8 32) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE 71S B 800 source : AC8 33) chain B residue 359 type sequence Y description BINDING SITE FOR RESIDUE 71S B 800 source : AC8 34) chain B residue 363 type sequence E description BINDING SITE FOR RESIDUE 71S B 800 source : AC8 35) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE 71S B 800 source : AC8 36) chain B residue 188 type sequence G description BINDING SITE FOR RESIDUE ACT B 860 source : AC9 37) chain B residue 190 type sequence I description BINDING SITE FOR RESIDUE ACT B 860 source : AC9 38) chain B residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT B 860 source : AC9 39) chain B residue 420 type sequence V description BINDING SITE FOR RESIDUE ACT B 860 source : AC9 40) chain B residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT B 860 source : AC9 41) chain B residue 106 type sequence V description BINDING SITE FOR RESIDUE GOL B 880 source : BC1 42) chain B residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL B 880 source : BC1 43) chain B residue 373 type sequence H description BINDING SITE FOR RESIDUE GOL B 880 source : BC1 44) chain B residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL B 880 source : BC1 45) chain B residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : BC2 46) chain B residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : BC2 47) chain B residue 96 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 48) chain B residue 101 type BINDING sequence C description BINDING => ECO:0000250|UniProtKB:P35228 source Swiss-Prot : SWS_FT_FI1 49) chain B residue 104 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 50) chain B residue 477 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 51) chain B residue 249 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 52) chain B residue 358 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 53) chain B residue 359 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 54) chain B residue 363 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 55) chain B residue 368 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 56) chain B residue 448 type BINDING sequence A description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 57) chain B residue 449 type BINDING sequence W description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 58) chain B residue 462 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI2 59) chain B residue 186 type BINDING sequence C description axial binding residue => ECO:0000250|UniProtKB:P29474 source Swiss-Prot : SWS_FT_FI3 60) chain B residue 185-192 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001

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