eF-site ID 4cu1-A PDB Code 4cu1 Chain A click to enlarge Title Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-[(2S)-3-amino-2-{5-[2-(6-amino-4-methylpyridin-2-yl)ethyl]pyridin-3-yl}propyl]-4-methylpyridin-2-amine Classification OXIDOREDUCTASE Compound NITRIC OXIDE SYNTHASE, ENDOTHELIAL Source Bos taurus (Bovine) (NOS3_BOVIN) Sequence A:  GPKFPRVKNWELGSITYDTLCAQSQQDGPCTPRRCLGSLV LPRPAEQLLSQARDFINQYYSSIKRSGSQAHEERLQEVEA EVASTGTYHLRESELVFGAKQAWRNAPRCVGRIQWGKLQV FDARDCSSAQEMFTYICNHIKYATNRGNLRSAITVFPQRA PGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCI QHGWTPGNGRFDVLPLLLQAPDEAPELFVLPPELVLEVPL EHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFSAAPFSG WYMSTEIGTRNLCDPHRYNILEDVAVXMDLDTRTTSSLWK DKAAVEINLAVLHSFQLAKVTIVDHHAATVSFMKHLDNEQ KARGGCPADWAWIVPPISGSLTPVFHQEMVNYILSPAFRY QPDPW Description (1)  NITRIC OXIDE SYNTHASE, ENDOTHELIAL (E.C.1.14.13.39) Functional site 1) chain A residue 180 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 2) chain A residue 185 type sequence R description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 3) chain A residue 186 type sequence C description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 4) chain A residue 187 type sequence V description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 5) chain A residue 188 type sequence G description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 6) chain A residue 228 type sequence S description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 7) chain A residue 355 type sequence F description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 8) chain A residue 356 type sequence S description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 9) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 10) chain A residue 360 type sequence M description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 11) chain A residue 363 type sequence E description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 12) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 13) chain A residue 475 type sequence F description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 14) chain A residue 477 type sequence Y description BINDING SITE FOR RESIDUE HEM A 500 source : AC1 15) chain A residue 104 type sequence S description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 16) chain A residue 106 type sequence V description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 17) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 18) chain A residue 448 type sequence A description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 19) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE H4B A 600 source : AC2 20) chain A residue 107 type sequence L description BINDING SITE FOR RESIDUE 71S A 800 source : AC3 21) chain A residue 249 type sequence Q description BINDING SITE FOR RESIDUE 71S A 800 source : AC3 22) chain A residue 338 type sequence V description BINDING SITE FOR RESIDUE 71S A 800 source : AC3 23) chain A residue 340 type sequence N description BINDING SITE FOR RESIDUE 71S A 800 source : AC3 24) chain A residue 355 type sequence F description BINDING SITE FOR RESIDUE 71S A 800 source : AC3 25) chain A residue 357 type sequence G description BINDING SITE FOR RESIDUE 71S A 800 source : AC3 26) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE 71S A 800 source : AC3 27) chain A residue 359 type sequence Y description BINDING SITE FOR RESIDUE 71S A 800 source : AC3 28) chain A residue 363 type sequence E description BINDING SITE FOR RESIDUE 71S A 800 source : AC3 29) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE 71S A 800 source : AC3 30) chain A residue 477 type sequence Y description BINDING SITE FOR RESIDUE 71S A 800 source : AC3 31) chain A residue 188 type sequence G description BINDING SITE FOR RESIDUE ACT A 860 source : AC4 32) chain A residue 358 type sequence W description BINDING SITE FOR RESIDUE ACT A 860 source : AC4 33) chain A residue 428 type sequence S description BINDING SITE FOR RESIDUE ACT A 860 source : AC4 34) chain A residue 106 type sequence V description BINDING SITE FOR RESIDUE GOL A 880 source : AC5 35) chain A residue 367 type sequence R description BINDING SITE FOR RESIDUE GOL A 880 source : AC5 36) chain A residue 373 type sequence H description BINDING SITE FOR RESIDUE GOL A 880 source : AC5 37) chain A residue 449 type sequence W description BINDING SITE FOR RESIDUE GOL A 880 source : AC5 38) chain A residue 447 type sequence W description BINDING SITE FOR RESIDUE H4B B 600 source : AC7 39) chain A residue 462 type sequence F description BINDING SITE FOR RESIDUE H4B B 600 source : AC7 40) chain A residue 463 type sequence H description BINDING SITE FOR RESIDUE H4B B 600 source : AC7 41) chain A residue 465 type sequence E description BINDING SITE FOR RESIDUE H4B B 600 source : AC7 42) chain A residue 76 type sequence W description BINDING SITE FOR RESIDUE 71S B 800 source : AC8 43) chain A residue 96 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : BC2 44) chain A residue 101 type sequence C description BINDING SITE FOR RESIDUE ZN B 900 source : BC2 45) chain A residue 185-192 type prosite sequence RCVGRIQW description NOS Nitric oxide synthase (NOS) signature. RCVGRIqW source prosite : PS60001

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