eF-site ID 4ci0-ABC PDB Code 4ci0 Chain A, B, C click to enlarge Title Electron cryo-microscopy of F420-reducing NiFe hydrogenase Frh Classification OXIDOREDUCTASE Compound F420-REDUCING HYDROGENASE, SUBUNIT ALPHA Source ORGANISM_SCIENTIFIC: METHANOTHERMOBACTER MARBURGENSIS; Sequence A:  SERIVISPTSRQEGHAELVMEVDDEGIVTKGRYFSITPVR GLEKMVTGKAPETAPVMVQRICGVCPIPHTLASVEAIDDS LDIEVPKAGRLLRELTLAAHHVNSHAIHHFLIAPDFVPEN LMADAINSVSEIRKNAQYVVDMVAGEGIHPSDVRIGGMAD NITELARKRLYARLKQLKPKVNEHVELMIGLIEDKGLPEG LGVHNQPTLASHQIYGDRTKFDLDRFTEIMPESWYDDPEI AKRACSTIPLYDGRNVEVGPRARMVEFQGFKERGVVAQHV ARALEMKTALSRAIEILDELDTSAPVRADFDERGTGKLGI GAIEAPRGLDVHMAKVENGKIQFYSALVPTTWNIPTMGPA TEGFHHEYGPHVIRAYDPCLSCATH B:  KPRIGYIHLSGCTGDAMSLTENYDILAELLTNMVDIVYGQ TLVDLWEMPEMDLALVEGSVCLQDEHSLHELKELREKAKL VCAFGSCAATGCFTRYSRGGQQAQPSHESFVPIADLIDVD LALPGCPPSPEIIAKTVVALLNNDMDYLQPMLDLAGYTEA CGCDLQTKVVNQGLCIGCGTCAMACQTRALDMTNGRPELN SDRCIKCGICYVQCPRSWWPEEQIKKEL C:  VLGTYKEIVSARSTDREIQKLAQDGGIVTGLLAYALDEGI IEGAVVAGPGEEFWKPQPMVAMSSDELKAAAGTKYTFSPN VMMLKKAVRQYGIEKLGTVAIPCQTMGIRKMQTYPFGVRF LADKIKLLVGIYCMENFPYTSLQTFICEKLGVSMELVEKM DIGKGKFWVYTQDDVLTLPLKETHGYEQAGCKICKDYVAE LADVSTGSVGSPDGWSTVITRTDAGDSIFKQAVEAGLFET KPIEEVKPGLGLLEKLAAQKKEKAEKNIAARKEMGLPTPF Description (1)  F420-REDUCING HYDROGENASE, SUBUNIT ALPHA (E.C.1.12.98.1), F420-REDUCING HYDROGENASE, SUBUNIT GAMMA (E.C.1.12.98.1), F420-REDUCING HYDROGENASE, SUBUNIT BETA (E.C.1.12.98.1) Functional site 1) chain A residue 66 type sequence C description BINDING SITE FOR RESIDUE FE A 1387 source : AC1 2) chain A residue 350 type sequence P description BINDING SITE FOR RESIDUE FE A 1387 source : AC1 3) chain A residue 383 type sequence C description BINDING SITE FOR RESIDUE FE A 1387 source : AC1 4) chain A residue 63 type sequence C description BINDING SITE FOR RESIDUE NI A 1388 source : AC2 5) chain A residue 66 type sequence C description BINDING SITE FOR RESIDUE NI A 1388 source : AC2 6) chain A residue 380 type sequence C description BINDING SITE FOR RESIDUE NI A 1388 source : AC2 7) chain A residue 383 type sequence C description BINDING SITE FOR RESIDUE NI A 1388 source : AC2 8) chain A residue 44 type sequence E description BINDING SITE FOR RESIDUE FE2 A 1389 source : AC3 9) chain A residue 347 type sequence A description BINDING SITE FOR RESIDUE FE2 A 1389 source : AC3 10) chain A residue 386 type sequence H description BINDING SITE FOR RESIDUE FE2 A 1389 source : AC3 11) chain B residue 56 type sequence G description BINDING SITE FOR RESIDUE SF4 B 1274 source : AC4 12) chain B residue 57 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1274 source : AC4 13) chain B residue 58 type sequence T description BINDING SITE FOR RESIDUE SF4 B 1274 source : AC4 14) chain B residue 59 type sequence G description BINDING SITE FOR RESIDUE SF4 B 1274 source : AC4 15) chain B residue 60 type sequence D description BINDING SITE FOR RESIDUE SF4 B 1274 source : AC4 16) chain B residue 130 type sequence G description BINDING SITE FOR RESIDUE SF4 B 1274 source : AC4 17) chain B residue 131 type sequence S description BINDING SITE FOR RESIDUE SF4 B 1274 source : AC4 18) chain B residue 132 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1274 source : AC4 19) chain B residue 171 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1274 source : AC4 20) chain B residue 229 type sequence A description BINDING SITE FOR RESIDUE SF4 B 1275 source : AC5 21) chain B residue 230 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1275 source : AC5 22) chain B residue 232 type sequence T description BINDING SITE FOR RESIDUE SF4 B 1275 source : AC5 23) chain B residue 235 type sequence L description BINDING SITE FOR RESIDUE SF4 B 1275 source : AC5 24) chain B residue 249 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1275 source : AC5 25) chain B residue 250 type sequence I description BINDING SITE FOR RESIDUE SF4 B 1275 source : AC5 26) chain B residue 252 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1275 source : AC5 27) chain B residue 253 type sequence G description BINDING SITE FOR RESIDUE SF4 B 1275 source : AC5 28) chain B residue 255 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1275 source : AC5 29) chain B residue 220 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1276 source : AC6 30) chain B residue 221 type sequence I description BINDING SITE FOR RESIDUE SF4 B 1276 source : AC6 31) chain B residue 222 type sequence G description BINDING SITE FOR RESIDUE SF4 B 1276 source : AC6 32) chain B residue 223 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1276 source : AC6 33) chain B residue 224 type sequence G description BINDING SITE FOR RESIDUE SF4 B 1276 source : AC6 34) chain B residue 225 type sequence T description BINDING SITE FOR RESIDUE SF4 B 1276 source : AC6 35) chain B residue 226 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1276 source : AC6 36) chain B residue 237 type sequence M description BINDING SITE FOR RESIDUE SF4 B 1276 source : AC6 37) chain B residue 242 type sequence P description BINDING SITE FOR RESIDUE SF4 B 1276 source : AC6 38) chain B residue 259 type sequence C description BINDING SITE FOR RESIDUE SF4 B 1276 source : AC6 39) chain B residue 260 type sequence P description BINDING SITE FOR RESIDUE SF4 B 1276 source : AC6 40) chain B residue 206 type sequence C description BINDING SITE FOR RESIDUE ZN B 1277 source : AC7 41) chain B residue 208 type sequence C description BINDING SITE FOR RESIDUE ZN B 1277 source : AC7 42) chain B residue 221 type sequence I description BINDING SITE FOR RESIDUE SF4 C 1282 source : AC8 43) chain C residue 102 type sequence I description BINDING SITE FOR RESIDUE SF4 C 1282 source : AC8 44) chain C residue 103 type sequence P description BINDING SITE FOR RESIDUE SF4 C 1282 source : AC8 45) chain C residue 104 type sequence C description BINDING SITE FOR RESIDUE SF4 C 1282 source : AC8 46) chain C residue 134 type sequence C description BINDING SITE FOR RESIDUE SF4 C 1282 source : AC8 47) chain C residue 135 type sequence M description BINDING SITE FOR RESIDUE SF4 C 1282 source : AC8 48) chain C residue 136 type sequence E description BINDING SITE FOR RESIDUE SF4 C 1282 source : AC8 49) chain C residue 137 type sequence N description BINDING SITE FOR RESIDUE SF4 C 1282 source : AC8 50) chain C residue 192 type sequence C description BINDING SITE FOR RESIDUE SF4 C 1282 source : AC8 51) chain C residue 195 type sequence C description BINDING SITE FOR RESIDUE SF4 C 1282 source : AC8 52) chain C residue 261 type sequence K description BINDING SITE FOR RESIDUE SF4 C 1282 source : AC8 53) chain C residue 23 type sequence A description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 54) chain C residue 24 type sequence Q description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 55) chain C residue 25 type sequence D description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 56) chain C residue 26 type sequence G description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 57) chain C residue 27 type sequence G description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 58) chain C residue 28 type sequence I description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 59) chain C residue 29 type sequence V description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 60) chain C residue 30 type sequence T description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 61) chain C residue 47 type sequence V description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 62) chain C residue 48 type sequence A description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 63) chain C residue 72 type sequence A description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 64) chain C residue 73 type sequence G description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 65) chain C residue 74 type sequence T description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 66) chain C residue 75 type sequence K description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 67) chain C residue 76 type sequence Y description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 68) chain C residue 77 type sequence T description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 69) chain C residue 81 type sequence N description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 70) chain C residue 102 type sequence I description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 71) chain C residue 105 type sequence Q description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 72) chain C residue 132 type sequence I description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 73) chain C residue 133 type sequence Y description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 74) chain C residue 134 type sequence C description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 75) chain C residue 135 type sequence M description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 76) chain C residue 137 type sequence N description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 77) chain C residue 198 type sequence Y description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 78) chain C residue 207 type sequence T description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 79) chain C residue 208 type sequence G description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 80) chain C residue 209 type sequence S description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 81) chain C residue 210 type sequence V description BINDING SITE FOR RESIDUE FAD C 1283 source : AC9 82) chain A residue 41-66 type prosite sequence RGLEKMVTGKAPETAPVMVQRICGVC description NI_HGENASE_L_1 Nickel-dependent hydrogenases large subunit signature 1. RGLEkmvtgkapetapvmvQRiCGVC source prosite : PS00507 83) chain A residue 377-386 type prosite sequence YDPCLSCATH description NI_HGENASE_L_2 Nickel-dependent hydrogenases large subunit signature 2. YDPCLSCat.H source prosite : PS00508 84) chain B residue 249-260 type prosite sequence CIKCGICYVQCP description 4FE4S_FER_1 4Fe-4S ferredoxin-type iron-sulfur binding region signature. CiKCGiCYvQCP source prosite : PS00198

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