eF-site ID 4cg6-ABCD PDB Code 4cg6 Chain A, B, C, D click to enlarge Title Cryo-em of the Sec61-complex bound to the 80s ribosome translating a membrane-inserting substrate Classification PROTEIN TRANSPORT Compound PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1 Source ORGANISM_COMMON: DOG; ORGANISM_SCIENTIFIC: CANIS LUPUS FAMILIARIS; Sequence A:  KIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYW MRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGD TPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMG AGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIA TNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRT DKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVD LPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVI SQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCHY LSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSG SSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFG GLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKE QSEVGSMGALLF B:  FVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAI MGFIGFFVKLIHIPINNIIVGG C:  EDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS D:  VFIVSVGSFISVLFIVI Description Functional site 1) chain A residue 75-94 type prosite sequence TLMELGISPIVTSGLIMQLL description SECY_1 Protein secY signature 1. TLMeLGIsPIVtSGLIMQLL source prosite : PS00755 2) chain A residue 164-182 type prosite sequence LLDELLQKGYGLGSGISLF description SECY_2 Protein secY signature 2. LLdElLQkgyGLGSGiSLF source prosite : PS00756 3) chain B residue 14-42 type prosite sequence FVKDSIRLVKRCTKPDRKEFQKIAMATAI description SECE_SEC61G Protein secE/sec61-gamma signature. FvKDsIrlVkRctKPdrkEfqkiaMATAI source prosite : PS01067 4) chain A residue 98-109 type TOPO_DOM sequence KIIEVGDTPKDR description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 5) chain A residue 168-177 type TOPO_DOM sequence LLQKGYGLGS description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 6) chain A residue 260-285 type TOPO_DOM sequence GFRVDLPIKSARYRGQYNTYPIKLFY description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 7) chain A residue 380-420 type TOPO_DOM sequence IEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPT A description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 8) chain A residue 459-476 type TOPO_DOM sequence EIFVKEQSEVGSMGALLF description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 9) chain C residue 72-91 type TRANSMEM sequence PVLVMSLLFIASVFMLHIWG description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 10) chain A residue 444-458 type TRANSMEM sequence GTGILLAVTIIYQYF description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 11) chain A residue 81-97 type TRANSMEM sequence ISPIVTSGLIMQLLAGA description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 12) chain A residue 110-131 type TRANSMEM sequence ALFNGAQKLFGMIITIGQSIVY description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 13) chain A residue 149-167 type TRANSMEM sequence LLITIQLFVAGLIVLLLDE description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 14) chain A residue 178-196 type TRANSMEM sequence GISLFIATNICETIVWKAF description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 15) chain A residue 242-259 type TRANSMEM sequence LMNLIATIFVFAVVIYFQ description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 16) chain A residue 286-306 type TRANSMEM sequence TSNIPIILQSALVSNLYVISQ description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 17) chain A residue 357-379 type TRANSMEM sequence DPVHAVVYIVFMLGSCAFFSKTW description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 18) chain A residue 421-437 type TRANSMEM sequence AAFGGLCIGALSVLADF description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 19) chain C residue 92-96 type TOPO_DOM sequence KYTRS description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI3 20) chain A residue 132-148 type TOPO_DOM sequence VMTGMYGDPSEMGAGIC description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI3 21) chain A residue 197-241 type TOPO_DOM sequence SPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYR QNLPN description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI3 22) chain A residue 307-356 type TOPO_DOM sequence MLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCHYLS PPESFGSVLE description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI3 23) chain A residue 438-443 type TOPO_DOM sequence LGAIGS description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI3

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