eF-site ID 4cg6-ABCD
PDB Code 4cg6
Chain A, B, C, D

click to enlarge
Title Cryo-em of the Sec61-complex bound to the 80s ribosome translating a membrane-inserting substrate
Classification PROTEIN TRANSPORT
Compound PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1
Source ORGANISM_COMMON: DOG; ORGANISM_SCIENTIFIC: CANIS LUPUS FAMILIARIS;
Sequence A:  KIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYW
MRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGD
TPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMG
AGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIA
TNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRT
DKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVD
LPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVI
SQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCHY
LSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSG
SSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFG
GLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKE
QSEVGSMGALLF
B:  FVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAI
MGFIGFFVKLIHIPINNIIVGG
C:  EDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS
D:  VFIVSVGSFISVLFIVI
Description


Functional site

1) chain A
residue 75-94
type prosite
sequence TLMELGISPIVTSGLIMQLL
description SECY_1 Protein secY signature 1. TLMeLGIsPIVtSGLIMQLL
source prosite : PS00755

2) chain A
residue 164-182
type prosite
sequence LLDELLQKGYGLGSGISLF
description SECY_2 Protein secY signature 2. LLdElLQkgyGLGSGiSLF
source prosite : PS00756

3) chain B
residue 14-42
type prosite
sequence FVKDSIRLVKRCTKPDRKEFQKIAMATAI
description SECE_SEC61G Protein secE/sec61-gamma signature. FvKDsIrlVkRctKPdrkEfqkiaMATAI
source prosite : PS01067

4) chain A
residue 98-109
type TOPO_DOM
sequence KIIEVGDTPKDR
description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

5) chain A
residue 168-177
type TOPO_DOM
sequence LLQKGYGLGS
description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

6) chain A
residue 260-285
type TOPO_DOM
sequence GFRVDLPIKSARYRGQYNTYPIKLFY
description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

7) chain A
residue 380-420
type TOPO_DOM
sequence IEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPT
A
description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

8) chain A
residue 459-476
type TOPO_DOM
sequence EIFVKEQSEVGSMGALLF
description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

9) chain C
residue 72-91
type TRANSMEM
sequence PVLVMSLLFIASVFMLHIWG
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

10) chain A
residue 444-458
type TRANSMEM
sequence GTGILLAVTIIYQYF
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

11) chain A
residue 81-97
type TRANSMEM
sequence ISPIVTSGLIMQLLAGA
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

12) chain A
residue 110-131
type TRANSMEM
sequence ALFNGAQKLFGMIITIGQSIVY
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

13) chain A
residue 149-167
type TRANSMEM
sequence LLITIQLFVAGLIVLLLDE
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

14) chain A
residue 178-196
type TRANSMEM
sequence GISLFIATNICETIVWKAF
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

15) chain A
residue 242-259
type TRANSMEM
sequence LMNLIATIFVFAVVIYFQ
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

16) chain A
residue 286-306
type TRANSMEM
sequence TSNIPIILQSALVSNLYVISQ
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

17) chain A
residue 357-379
type TRANSMEM
sequence DPVHAVVYIVFMLGSCAFFSKTW
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

18) chain A
residue 421-437
type TRANSMEM
sequence AAFGGLCIGALSVLADF
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

19) chain C
residue 92-96
type TOPO_DOM
sequence KYTRS
description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI3

20) chain A
residue 132-148
type TOPO_DOM
sequence VMTGMYGDPSEMGAGIC
description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI3

21) chain A
residue 197-241
type TOPO_DOM
sequence SPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYR
QNLPN
description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI3

22) chain A
residue 307-356
type TOPO_DOM
sequence MLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCHYLS
PPESFGSVLE
description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI3

23) chain A
residue 438-443
type TOPO_DOM
sequence LGAIGS
description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI3


Display surface

Download
Links