eF-site ID 4cg6-A PDB Code 4cg6 Chain A click to enlarge Title Cryo-em of the Sec61-complex bound to the 80s ribosome translating a membrane-inserting substrate Classification PROTEIN TRANSPORT Compound PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1 Source ORGANISM_COMMON: DOG; ORGANISM_SCIENTIFIC: CANIS LUPUS FAMILIARIS; Sequence A:  KIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYW MRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGD TPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMG AGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIA TNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRT DKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVD LPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVI SQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCHY LSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSG SSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFG GLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKE QSEVGSMGALLF Description (1)  PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT GAMMA, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT BETA, PEPTIDE Functional site 1) chain A residue 98-109 type TOPO_DOM sequence KIIEVGDTPKDR description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 2) chain A residue 168-177 type TOPO_DOM sequence LLQKGYGLGS description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 3) chain A residue 260-285 type TOPO_DOM sequence GFRVDLPIKSARYRGQYNTYPIKLFY description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 4) chain A residue 380-420 type TOPO_DOM sequence IEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPT A description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 5) chain A residue 459-476 type TOPO_DOM sequence EIFVKEQSEVGSMGALLF description Cytoplasmic => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 6) chain A residue 444-458 type TRANSMEM sequence GTGILLAVTIIYQYF description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 7) chain A residue 81-97 type TRANSMEM sequence ISPIVTSGLIMQLLAGA description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 8) chain A residue 110-131 type TRANSMEM sequence ALFNGAQKLFGMIITIGQSIVY description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 9) chain A residue 149-167 type TRANSMEM sequence LLITIQLFVAGLIVLLLDE description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 10) chain A residue 178-196 type TRANSMEM sequence GISLFIATNICETIVWKAF description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 11) chain A residue 242-259 type TRANSMEM sequence LMNLIATIFVFAVVIYFQ description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 12) chain A residue 286-306 type TRANSMEM sequence TSNIPIILQSALVSNLYVISQ description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 13) chain A residue 357-379 type TRANSMEM sequence DPVHAVVYIVFMLGSCAFFSKTW description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 14) chain A residue 421-437 type TRANSMEM sequence AAFGGLCIGALSVLADF description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 15) chain A residue 132-148 type TOPO_DOM sequence VMTGMYGDPSEMGAGIC description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI3 16) chain A residue 197-241 type TOPO_DOM sequence SPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYR QNLPN description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI3 17) chain A residue 307-356 type TOPO_DOM sequence MLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCHYLS PPESFGSVLE description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI3 18) chain A residue 438-443 type TOPO_DOM sequence LGAIGS description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI3 19) chain A residue 75-94 type prosite sequence TLMELGISPIVTSGLIMQLL description SECY_1 Protein secY signature 1. TLMeLGIsPIVtSGLIMQLL source prosite : PS00755 20) chain A residue 164-182 type prosite sequence LLDELLQKGYGLGSGISLF description SECY_2 Protein secY signature 2. LLdElLQkgyGLGSGiSLF source prosite : PS00756

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