eF-site ID 4cg5-ABC PDB Code 4cg5 Chain A, B, C click to enlarge Title Cryo-EM of the Sec61-complex bound to the 80S ribosome translating a secretory substrate Classification PROTEIN TRANSPORT Compound PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1 Source ORGANISM_COMMON: DOG; ORGANISM_SCIENTIFIC: CANIS LUPUS FAMILIARIS; Sequence A:  KIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYW MRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGD TPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMG AGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIA TNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRT DKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVD LPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVI SQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCHY LSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSG SSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFG GLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKE QSEVGSMGALLF B:  FVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAI MGFIGFFVKLIHIPINNIIVGG C:  EDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS Description (1)  PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT GAMMA, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT BETA Functional site 1) chain C residue 72-91 type TRANSMEM sequence PVLVMSLLFIASVFMLHIWG description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 2) chain A residue 98-109 type TRANSMEM sequence KIIEVGDTPKDR description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 3) chain A residue 168-177 type TRANSMEM sequence LLQKGYGLGS description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 4) chain A residue 260-285 type TRANSMEM sequence GFRVDLPIKSARYRGQYNTYPIKLFY description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 5) chain A residue 380-420 type TRANSMEM sequence IEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPT A description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 6) chain A residue 459-476 type TRANSMEM sequence EIFVKEQSEVGSMGALLF description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI1 7) chain C residue 92-96 type TOPO_DOM sequence KYTRS description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 8) chain A residue 81-97 type TOPO_DOM sequence ISPIVTSGLIMQLLAGA description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 9) chain A residue 110-131 type TOPO_DOM sequence ALFNGAQKLFGMIITIGQSIVY description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 10) chain A residue 149-167 type TOPO_DOM sequence LLITIQLFVAGLIVLLLDE description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 11) chain A residue 178-196 type TOPO_DOM sequence GISLFIATNICETIVWKAF description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 12) chain A residue 242-259 type TOPO_DOM sequence LMNLIATIFVFAVVIYFQ description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 13) chain A residue 286-306 type TOPO_DOM sequence TSNIPIILQSALVSNLYVISQ description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 14) chain A residue 357-379 type TOPO_DOM sequence DPVHAVVYIVFMLGSCAFFSKTW description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 15) chain A residue 421-437 type TOPO_DOM sequence AAFGGLCIGALSVLADF description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 16) chain A residue 444-458 type TOPO_DOM sequence GTGILLAVTIIYQYF description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI2 17) chain B residue 62-68 type TOPO_DOM sequence NNIIVGG description Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI3 18) chain A residue 132-148 type TOPO_DOM sequence VMTGMYGDPSEMGAGIC description Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI3 19) chain A residue 197-241 type TOPO_DOM sequence SPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYR QNLPN description Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI3 20) chain A residue 307-356 type TOPO_DOM sequence MLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCHYLS PPESFGSVLE description Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI3 21) chain A residue 438-443 type TOPO_DOM sequence LGAIGS description Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT source Swiss-Prot : SWS_FT_FI3 22) chain B residue 18 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P60059 source Swiss-Prot : SWS_FT_FI5 23) chain A residue 75-94 type prosite sequence TLMELGISPIVTSGLIMQLL description SECY_1 Protein secY signature 1. TLMeLGIsPIVtSGLIMQLL source prosite : PS00755 24) chain A residue 164-182 type prosite sequence LLDELLQKGYGLGSGISLF description SECY_2 Protein secY signature 2. LLdElLQkgyGLGSGiSLF source prosite : PS00756 25) chain B residue 14-42 type prosite sequence FVKDSIRLVKRCTKPDRKEFQKIAMATAI description SECE_SEC61G Protein secE/sec61-gamma signature. FvKDsIrlVkRctKPdrkEfqkiaMATAI source prosite : PS01067

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