eF-site ID 4cg5-A
PDB Code 4cg5
Chain A

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Title Cryo-EM of the Sec61-complex bound to the 80S ribosome translating a secretory substrate
Classification PROTEIN TRANSPORT
Compound PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1
Source ORGANISM_COMMON: DOG; ORGANISM_SCIENTIFIC: CANIS LUPUS FAMILIARIS;
Sequence A:  KIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYW
MRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGD
TPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMG
AGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIA
TNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRT
DKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVD
LPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVI
SQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCHY
LSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSG
SSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFG
GLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKE
QSEVGSMGALLF
Description (1)  PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 1, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT GAMMA, PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT BETA


Functional site

1) chain A
residue 75-94
type prosite
sequence TLMELGISPIVTSGLIMQLL
description SECY_1 Protein secY signature 1. TLMeLGIsPIVtSGLIMQLL
source prosite : PS00755

2) chain A
residue 164-182
type prosite
sequence LLDELLQKGYGLGSGISLF
description SECY_2 Protein secY signature 2. LLdElLQkgyGLGSGiSLF
source prosite : PS00756

3) chain A
residue 98-109
type TRANSMEM
sequence KIIEVGDTPKDR
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

4) chain A
residue 168-177
type TRANSMEM
sequence LLQKGYGLGS
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

5) chain A
residue 260-285
type TRANSMEM
sequence GFRVDLPIKSARYRGQYNTYPIKLFY
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

6) chain A
residue 380-420
type TRANSMEM
sequence IEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPT
A
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

7) chain A
residue 459-476
type TRANSMEM
sequence EIFVKEQSEVGSMGALLF
description Helical => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI1

8) chain A
residue 444-458
type TOPO_DOM
sequence GTGILLAVTIIYQYF
description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

9) chain A
residue 81-97
type TOPO_DOM
sequence ISPIVTSGLIMQLLAGA
description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

10) chain A
residue 110-131
type TOPO_DOM
sequence ALFNGAQKLFGMIITIGQSIVY
description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

11) chain A
residue 149-167
type TOPO_DOM
sequence LLITIQLFVAGLIVLLLDE
description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

12) chain A
residue 178-196
type TOPO_DOM
sequence GISLFIATNICETIVWKAF
description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

13) chain A
residue 242-259
type TOPO_DOM
sequence LMNLIATIFVFAVVIYFQ
description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

14) chain A
residue 286-306
type TOPO_DOM
sequence TSNIPIILQSALVSNLYVISQ
description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

15) chain A
residue 357-379
type TOPO_DOM
sequence DPVHAVVYIVFMLGSCAFFSKTW
description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

16) chain A
residue 421-437
type TOPO_DOM
sequence AAFGGLCIGALSVLADF
description Lumenal => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI2

17) chain A
residue 132-148
type TOPO_DOM
sequence VMTGMYGDPSEMGAGIC
description Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI3

18) chain A
residue 197-241
type TOPO_DOM
sequence SPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYR
QNLPN
description Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI3

19) chain A
residue 307-356
type TOPO_DOM
sequence MLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCHYLS
PPESFGSVLE
description Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI3

20) chain A
residue 438-443
type TOPO_DOM
sequence LGAIGS
description Extracellular => ECO:0000269|PubMed:36261528, ECO:0007744|PDB:7TM3, ECO:0007744|PDB:7TUT
source Swiss-Prot : SWS_FT_FI3


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