eF-site ID 4cfl-A PDB Code 4cfl Chain A click to enlarge Title N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH LY303511 Classification CELL CYCLE Compound BRD4 PROTEIN Source Homo sapiens (Human) (Q6NXE4_HUMAN) Sequence A:  SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAW PFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWN AQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI NELPTEE Description Functional site 1) chain A residue 81 type sequence W description BINDING SITE FOR RESIDUE 8DQ A 1169 source : AC1 2) chain A residue 82 type sequence P description BINDING SITE FOR RESIDUE 8DQ A 1169 source : AC1 3) chain A residue 87 type sequence V description BINDING SITE FOR RESIDUE 8DQ A 1169 source : AC1 4) chain A residue 92 type sequence L description BINDING SITE FOR RESIDUE 8DQ A 1169 source : AC1 5) chain A residue 94 type sequence L description BINDING SITE FOR RESIDUE 8DQ A 1169 source : AC1 6) chain A residue 140 type sequence N description BINDING SITE FOR RESIDUE 8DQ A 1169 source : AC1 7) chain A residue 146 type sequence I description BINDING SITE FOR RESIDUE 8DQ A 1169 source : AC1 8) chain A residue 100 type sequence I description BINDING SITE FOR RESIDUE EDO A 1170 source : AC2 9) chain A residue 101 type sequence I description BINDING SITE FOR RESIDUE EDO A 1170 source : AC2 10) chain A residue 102 type sequence K description BINDING SITE FOR RESIDUE EDO A 1170 source : AC2 11) chain A residue 103 type sequence T description BINDING SITE FOR RESIDUE EDO A 1170 source : AC2 12) chain A residue 135 type sequence N description BINDING SITE FOR RESIDUE EDO A 1170 source : AC2 13) chain A residue 57 type sequence K description BINDING SITE FOR RESIDUE GOL A 1171 source : AC3 14) chain A residue 144 type sequence D description BINDING SITE FOR RESIDUE GOL A 1171 source : AC3 15) chain A residue 145 type sequence D description BINDING SITE FOR RESIDUE GOL A 1171 source : AC3 16) chain A residue 146 type sequence I description BINDING SITE FOR RESIDUE GOL A 1171 source : AC3 17) chain A residue 80-139 type prosite sequence AWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY WNAQECIQDFNTMFTNCYIY description BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY source prosite : PS00633 18) chain A residue 140 type SITE sequence N description Acetylated histone binding => ECO:0000269|PubMed:22464331 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 99 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI2

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