eF-site ID 4cfh-A PDB Code 4cfh Chain A click to enlarge Title Structure of an active form of mammalian AMPK Classification TRANSFERASE Compound 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 Source (AAKG1_RAT) Sequence A:  RVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILNR QKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSDI FMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVDY CHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEF LRXSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALLC GTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHML QVDPMKRATIKDIREHEWFKQDLPKYLFPEDAVAYHLIID NRRIMNEAKDFYLATSPPDSFLDDHHLTRPHPERVPFLVA ETPRAAKWHLGIRSQSRPNDIMAEVCRAIKQLDYEWKVVN PYYLRVRRKNPVTSTFSKMSLQLYQVDSRTYLLDFRSIDD EI Description Functional site 1) chain A residue 22 type sequence L description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 2) chain A residue 23 type sequence G description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 3) chain A residue 24 type sequence V description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 4) chain A residue 25 type sequence G description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 5) chain A residue 43 type sequence A description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 6) chain A residue 45 type sequence K description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 7) chain A residue 93 type sequence M description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 8) chain A residue 94 type sequence E description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 9) chain A residue 95 type sequence Y description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 10) chain A residue 96 type sequence V description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 11) chain A residue 99 type sequence G description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 12) chain A residue 100 type sequence E description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 13) chain A residue 143 type sequence E description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 14) chain A residue 144 type sequence N description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 15) chain A residue 146 type sequence L description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 16) chain A residue 157 type sequence D description BINDING SITE FOR RESIDUE STU A 1550 source : AC3 17) chain A residue 344 type MOD_RES sequence T description Phosphoserine; by ULK1 => ECO:0000305|PubMed:21460634 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 371 type MOD_RES sequence T description Phosphoserine; by ULK1 => ECO:0000305|PubMed:21460634 source Swiss-Prot : SWS_FT_FI3 19) chain A residue 345 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:Q13131 source Swiss-Prot : SWS_FT_FI6 20) chain A residue 456 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:Q13131 source Swiss-Prot : SWS_FT_FI6 21) chain A residue 349 type MOD_RES sequence S description Phosphoserine; by ULK1 => ECO:0000305|PubMed:21460634 source Swiss-Prot : SWS_FT_FI7 22) chain A residue 357 type MOD_RES sequence T description Phosphothreonine; by ULK1 => ECO:0000305|PubMed:21460634 source Swiss-Prot : SWS_FT_FI8 23) chain A residue 22-45 type prosite sequence LGVGTFGKVKVGKHELTGHKVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGVGTFGKVKvGkheltghk..........VAVK source prosite : PS00107 24) chain A residue 135-147 type prosite sequence VVHRDLKPENVLL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpeNVLL source prosite : PS00108

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