eF-site ID 4cde-ABCDEF PDB Code 4cde Chain A, B, C, D, E, F click to enlarge Title Human DPP1 in complex with 4-amino-N-((1S)-1-cyano-2-(4-(4- cyanophenyl)phenyl)ethyl)tetrahydropyran-4-carboxamide Classification HYDROLASE Compound DIPEPTIDYL PEPTIDASE 1 EXCLUSION DOMAIN CHAIN Source (CATC_HUMAN) Sequence A:  DTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKV VVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAF FKYKEEGSKVTTYCNETMTGWVHDVLGRNWACFTGKKV B:  HLPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEA RIRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGK YAQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVG GFYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYH H C:  PFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGE NGYFRIRRGTDECAIESIAVAATPIPKL D:  DTPANCTYLDLLGTWVFQVGSSGSQRDVNCSVMGPQEKKV VVYLQKLDTAYDDLGNSGHFTIIYNQGFEIVLNDYKWFAF FKYKKVTTYCNETMTGWVHDVLGRNWACFTGKKV E:  LPTSWDWRNVHGINFVSPVRNQASCGSCYSFASMGMLEAR IRILTNNSQTPILSPQEVVSCSQYAQGCEGGFPYLIAGKY AQDFGLVEEACFPYTGTDSPCKMKEDCFRYYSSEYHYVGG FYGGCNEALMKLELVHHGPMAVAFEVYDDFLHYKKGIYHH T F:  PFNPFELTNHAVLLVGYGTDSASGMDYWIVKNSWGTGWGE NGYFRIRRGTDECAIESIAVAATPIPKL Description Functional site 1) chain C residue 381 type ACT_SITE sequence H description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10089 source Swiss-Prot : SWS_FT_FI1 2) chain F residue 381 type ACT_SITE sequence H description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10089 source Swiss-Prot : SWS_FT_FI1 3) chain C residue 403 type ACT_SITE sequence N description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090 source Swiss-Prot : SWS_FT_FI2 4) chain F residue 403 type ACT_SITE sequence N description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090 source Swiss-Prot : SWS_FT_FI2 5) chain B residue 323 type ACT_SITE sequence Y description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090 source Swiss-Prot : SWS_FT_FI2 6) chain E residue 278 type ACT_SITE sequence F description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090 source Swiss-Prot : SWS_FT_FI2 7) chain E residue 280 type ACT_SITE sequence Y description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090 source Swiss-Prot : SWS_FT_FI2 8) chain E residue 323 type ACT_SITE sequence Y description ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10090 source Swiss-Prot : SWS_FT_FI2 9) chain B residue 252 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329 source Swiss-Prot : SWS_FT_FI3 10) chain E residue 252 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19167329 source Swiss-Prot : SWS_FT_FI3 11) chain C residue 379-389 type prosite sequence TNHAVLLVGYG description THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. TNHAVLLVGYG source prosite : PS00639 12) chain C residue 398-417 type prosite sequence YWIVKNSWGTGWGENGYFRI description THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWIvKNSWgtgWGenGYFrI source prosite : PS00640 13) chain B residue 228-239 type prosite sequence QASCGSCYSFAS description THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QAsCGSCYSfAS source prosite : PS00139

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