eF-site ID 4ccm-ABCD PDB Code 4ccm Chain A, B, C, D click to enlarge Title 60S ribosomal protein L8 histidine hydroxylase (NO66) in complex with Mn(II), N-oxalylglycine (NOG) and 60S ribosomal protein L8 (RPL8 G220C) peptide fragment (complex-1) Classification OXIDOREDUCTASE Compound BIFUNCTIONAL LYSINE-SPECIFIC DEMETHYLASE AND HISTIDYL-HYDROXYLASE NO66 Source (RL8_HUMAN) Sequence A:  MSPLRRVLAELNRIPSSRRRAARLFEWLIAPMPPDHFYRR LWEREAVLVRRQDHTYYQGLFSTADLDSMLRNEEVQFGQH LDAARYINGRRETLNPPGRALPAAAWSLYQAGCSLRLLCP QAFSTTVWQFLAVLQEQFGSMAGSNVYLTPPNSQGFAPHY DDIEAFVLQLEGRKLWRVYRPRVPTEELALTSSPNFSQDD LGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLS TYQRNTWGDFLEAILPLAVQAAMEENVEFRRGLPRDFMDY MGAQHSDSKDPRRTAFMEKVRVLVARLGHFAPVDAVADQR AKDFIHDSLPPVLTDRERALSVYGLPIRWEGEPVNVGAQL TTETEVHMLQDGIARLVGEGGHLFLYYTVENSRVYHLEEP KCLEIYPQQADAMELLLGSYPEFVRVGDLPCDSVEDQLSL ATTLYDKGLLLTKMPLA B:  MSPLRRVLAELNRIPSSRRRAARLFEWLIAPMPPDHFYRR LWEREAVLVRRQDHTYYQGLFSTADLDSMLRNEEVQFGQH LDAARYINGRRETLNPPGRALPAAAWSLYQAGCSLRLLCP QAFSTTVWQFLAVLQEQFGSMAGSNVYLTPPNSQGFAPHY DDIEAFVLQLEGRKLWRVYRPRVPTEELALTSSPNFSQDD LGEPVLQTVLEPGDLLYFPRGFIHQAECQDGVHSLHLTLS TYQRNTWGDFLEAILPLAVQAAMEENVEFRRGLPRDFMDY MGAQHSDSKDPRRTAFMEKVRVLVARLGHFAPVDAVADQR AKDFIHDSLPPVLTDRERALSVYGLPIRWEAGEPVNVGAQ LTTETEVHMLQDGIARLVGEGGHLFLYYTVENSRVYHLEE PKCLEIYPQQADAMELLLGSYPEFVRVGDLPCDSVEDQLS LATTLYDKGLLLTKMPLAL C:  NHQHICKP D:  GGGNHQHICKP Description Functional site 1) chain A residue 340 type sequence H description BINDING SITE FOR RESIDUE MN A 901 source : AC1 2) chain A residue 342 type sequence D description BINDING SITE FOR RESIDUE MN A 901 source : AC1 3) chain A residue 405 type sequence H description BINDING SITE FOR RESIDUE MN A 901 source : AC1 4) chain A residue 328 type sequence Y description BINDING SITE FOR RESIDUE OGA A 902 source : AC2 5) chain A residue 337 type sequence F description BINDING SITE FOR RESIDUE OGA A 902 source : AC2 6) chain A residue 340 type sequence H description BINDING SITE FOR RESIDUE OGA A 902 source : AC2 7) chain A residue 342 type sequence D description BINDING SITE FOR RESIDUE OGA A 902 source : AC2 8) chain A residue 355 type sequence K description BINDING SITE FOR RESIDUE OGA A 902 source : AC2 9) chain A residue 357 type sequence W description BINDING SITE FOR RESIDUE OGA A 902 source : AC2 10) chain A residue 405 type sequence H description BINDING SITE FOR RESIDUE OGA A 902 source : AC2 11) chain A residue 417 type sequence H description BINDING SITE FOR RESIDUE OGA A 902 source : AC2 12) chain A residue 419 type sequence T description BINDING SITE FOR RESIDUE OGA A 902 source : AC2 13) chain A residue 452 type sequence R description BINDING SITE FOR RESIDUE EDO A 903 source : AC3 14) chain B residue 224 type sequence E description BINDING SITE FOR RESIDUE EDO A 903 source : AC3 15) chain B residue 340 type sequence H description BINDING SITE FOR RESIDUE MN B 901 source : AC4 16) chain B residue 342 type sequence D description BINDING SITE FOR RESIDUE MN B 901 source : AC4 17) chain B residue 405 type sequence H description BINDING SITE FOR RESIDUE MN B 901 source : AC4 18) chain B residue 328 type sequence Y description BINDING SITE FOR RESIDUE OGA B 902 source : AC5 19) chain B residue 337 type sequence F description BINDING SITE FOR RESIDUE OGA B 902 source : AC5 20) chain B residue 340 type sequence H description BINDING SITE FOR RESIDUE OGA B 902 source : AC5 21) chain B residue 342 type sequence D description BINDING SITE FOR RESIDUE OGA B 902 source : AC5 22) chain B residue 355 type sequence K description BINDING SITE FOR RESIDUE OGA B 902 source : AC5 23) chain B residue 405 type sequence H description BINDING SITE FOR RESIDUE OGA B 902 source : AC5 24) chain B residue 417 type sequence H description BINDING SITE FOR RESIDUE OGA B 902 source : AC5 25) chain B residue 419 type sequence T description BINDING SITE FOR RESIDUE OGA B 902 source : AC5 26) chain A residue 320 type sequence G description BINDING SITE FOR RESIDUE EDO B 903 source : AC6 27) chain A residue 321 type sequence S description BINDING SITE FOR RESIDUE EDO B 903 source : AC6 28) chain A residue 426 type sequence N description BINDING SITE FOR RESIDUE EDO B 903 source : AC6 29) chain A residue 501 type sequence R description BINDING SITE FOR RESIDUE EDO B 903 source : AC6 30) chain B residue 458 type sequence F description BINDING SITE FOR RESIDUE EDO B 903 source : AC6 31) chain A residue 458 type sequence F description BINDING SITE FOR RESIDUE EDO B 904 source : AC7 32) chain B residue 320 type sequence G description BINDING SITE FOR RESIDUE EDO B 904 source : AC7 33) chain B residue 321 type sequence S description BINDING SITE FOR RESIDUE EDO B 904 source : AC7 34) chain B residue 426 type sequence N description BINDING SITE FOR RESIDUE EDO B 904 source : AC7 35) chain B residue 501 type sequence R description BINDING SITE FOR RESIDUE EDO B 904 source : AC7 36) chain C residue 216 type MOD_RES sequence H description (3S)-3-hydroxyhistidine => ECO:0000269|PubMed:23103944 source Swiss-Prot : SWS_FT_FI1 37) chain D residue 216 type MOD_RES sequence H description (3S)-3-hydroxyhistidine => ECO:0000269|PubMed:23103944 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 405 type MOD_RES sequence H description (3S)-3-hydroxyhistidine => ECO:0000269|PubMed:23103944 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 340 type MOD_RES sequence H description (3S)-3-hydroxyhistidine => ECO:0000269|PubMed:23103944 source Swiss-Prot : SWS_FT_FI1 40) chain B residue 342 type MOD_RES sequence D description (3S)-3-hydroxyhistidine => ECO:0000269|PubMed:23103944 source Swiss-Prot : SWS_FT_FI1 41) chain B residue 405 type MOD_RES sequence H description (3S)-3-hydroxyhistidine => ECO:0000269|PubMed:23103944 source Swiss-Prot : SWS_FT_FI1

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