eF-site ID 4cby-D PDB Code 4cby Chain D click to enlarge Title Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease Classification HYDROLASE Compound HISTONE DEACETYLASE 4 Source Homo sapiens (Human) (HDAC4_HUMAN) Sequence D:  TTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQET GLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPANRQK LDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAAR LAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGF CYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFY SDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNM AFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSG FDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLAL EGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNAN AVRSMEKVMEIHSKYWRCLQRHH Description (1)  HISTONE DEACETYLASE 4 (E.C.3.5.1.98) Functional site 1) chain D residue 677 type sequence E description BINDING SITE FOR RESIDUE KEE D 2036 source : BC7 2) chain D residue 681 type sequence R description BINDING SITE FOR RESIDUE KEE D 2036 source : BC7 3) chain D residue 802 type sequence H description BINDING SITE FOR RESIDUE KEE D 2036 source : BC7 4) chain D residue 803 type sequence H description BINDING SITE FOR RESIDUE KEE D 2036 source : BC7 5) chain D residue 812 type sequence F description BINDING SITE FOR RESIDUE KEE D 2036 source : BC7 6) chain D residue 840 type sequence D description BINDING SITE FOR RESIDUE KEE D 2036 source : BC7 7) chain D residue 842 type sequence H description BINDING SITE FOR RESIDUE KEE D 2036 source : BC7 8) chain D residue 871 type sequence F description BINDING SITE FOR RESIDUE KEE D 2036 source : BC7 9) chain D residue 934 type sequence D description BINDING SITE FOR RESIDUE KEE D 2036 source : BC7 10) chain D residue 840 type sequence D description BINDING SITE FOR RESIDUE ZN D 2037 source : BC8 11) chain D residue 842 type sequence H description BINDING SITE FOR RESIDUE ZN D 2037 source : BC8 12) chain D residue 934 type sequence D description BINDING SITE FOR RESIDUE ZN D 2037 source : BC8 13) chain D residue 667 type sequence C description BINDING SITE FOR RESIDUE ZN D 2038 source : BC9 14) chain D residue 669 type sequence C description BINDING SITE FOR RESIDUE ZN D 2038 source : BC9 15) chain D residue 675 type sequence H description BINDING SITE FOR RESIDUE ZN D 2038 source : BC9 16) chain D residue 751 type sequence C description BINDING SITE FOR RESIDUE ZN D 2038 source : BC9 17) chain D residue 838 type sequence D description BINDING SITE FOR RESIDUE NA D 2039 source : CC1 18) chain D residue 840 type sequence D description BINDING SITE FOR RESIDUE NA D 2039 source : CC1 19) chain D residue 842 type sequence H description BINDING SITE FOR RESIDUE NA D 2039 source : CC1 20) chain D residue 861 type sequence S description BINDING SITE FOR RESIDUE NA D 2039 source : CC1 21) chain D residue 862 type sequence L description BINDING SITE FOR RESIDUE NA D 2039 source : CC1 22) chain D residue 851 type sequence F description BINDING SITE FOR RESIDUE NA D 2040 source : CC2 23) chain D residue 854 type sequence D description BINDING SITE FOR RESIDUE NA D 2040 source : CC2 24) chain D residue 857 type sequence V description BINDING SITE FOR RESIDUE NA D 2040 source : CC2 25) chain D residue 888 type sequence F description BINDING SITE FOR RESIDUE NA D 2040 source : CC2 26) chain D residue 803 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 27) chain D residue 667 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 28) chain D residue 669 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 29) chain D residue 675 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 30) chain D residue 751 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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