eF-site ID 4cby-C PDB Code 4cby Chain C click to enlarge Title Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease Classification HYDROLASE Compound HISTONE DEACETYLASE 4 Source Homo sapiens (Human) (HDAC4_HUMAN) Sequence C:  TTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQET GLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPANRQK LDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAAR LAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGF CYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFY SDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNM AFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSG FDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLAL EGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNAN AVRSMEKVMEIHSKYWRCLQ Description (1)  HISTONE DEACETYLASE 4 (E.C.3.5.1.98) Functional site 1) chain C residue 802 type sequence H description BINDING SITE FOR RESIDUE KEE C 2033 source : BC2 2) chain C residue 803 type sequence H description BINDING SITE FOR RESIDUE KEE C 2033 source : BC2 3) chain C residue 812 type sequence F description BINDING SITE FOR RESIDUE KEE C 2033 source : BC2 4) chain C residue 840 type sequence D description BINDING SITE FOR RESIDUE KEE C 2033 source : BC2 5) chain C residue 842 type sequence H description BINDING SITE FOR RESIDUE KEE C 2033 source : BC2 6) chain C residue 871 type sequence F description BINDING SITE FOR RESIDUE KEE C 2033 source : BC2 7) chain C residue 934 type sequence D description BINDING SITE FOR RESIDUE KEE C 2033 source : BC2 8) chain C residue 840 type sequence D description BINDING SITE FOR RESIDUE ZN C 2034 source : BC3 9) chain C residue 842 type sequence H description BINDING SITE FOR RESIDUE ZN C 2034 source : BC3 10) chain C residue 934 type sequence D description BINDING SITE FOR RESIDUE ZN C 2034 source : BC3 11) chain C residue 667 type sequence C description BINDING SITE FOR RESIDUE ZN C 2035 source : BC4 12) chain C residue 669 type sequence C description BINDING SITE FOR RESIDUE ZN C 2035 source : BC4 13) chain C residue 675 type sequence H description BINDING SITE FOR RESIDUE ZN C 2035 source : BC4 14) chain C residue 751 type sequence C description BINDING SITE FOR RESIDUE ZN C 2035 source : BC4 15) chain C residue 838 type sequence D description BINDING SITE FOR RESIDUE NA C 2036 source : BC5 16) chain C residue 840 type sequence D description BINDING SITE FOR RESIDUE NA C 2036 source : BC5 17) chain C residue 842 type sequence H description BINDING SITE FOR RESIDUE NA C 2036 source : BC5 18) chain C residue 861 type sequence S description BINDING SITE FOR RESIDUE NA C 2036 source : BC5 19) chain C residue 862 type sequence L description BINDING SITE FOR RESIDUE NA C 2036 source : BC5 20) chain C residue 851 type sequence F description BINDING SITE FOR RESIDUE NA C 2037 source : BC6 21) chain C residue 854 type sequence D description BINDING SITE FOR RESIDUE NA C 2037 source : BC6 22) chain C residue 857 type sequence V description BINDING SITE FOR RESIDUE NA C 2037 source : BC6 23) chain C residue 888 type sequence F description BINDING SITE FOR RESIDUE NA C 2037 source : BC6 24) chain C residue 803 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 25) chain C residue 669 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 26) chain C residue 675 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 27) chain C residue 751 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 28) chain C residue 667 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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