eF-site ID 4cby-B PDB Code 4cby Chain B click to enlarge Title Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease Classification HYDROLASE Compound HISTONE DEACETYLASE 4 Source Homo sapiens (Human) (HDAC4_HUMAN) Sequence B:  FTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQE TGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPANRQ KLDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAA RLAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMG FCYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAF YSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVN MAFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSS GFDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLA LEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNA NAVRSMEKVMEIHSKYWRCL Description (1)  HISTONE DEACETYLASE 4 (E.C.3.5.1.98) Functional site 1) chain B residue 681 type sequence R description BINDING SITE FOR RESIDUE KEE B 2032 source : AC6 2) chain B residue 802 type sequence H description BINDING SITE FOR RESIDUE KEE B 2032 source : AC6 3) chain B residue 803 type sequence H description BINDING SITE FOR RESIDUE KEE B 2032 source : AC6 4) chain B residue 812 type sequence F description BINDING SITE FOR RESIDUE KEE B 2032 source : AC6 5) chain B residue 840 type sequence D description BINDING SITE FOR RESIDUE KEE B 2032 source : AC6 6) chain B residue 842 type sequence H description BINDING SITE FOR RESIDUE KEE B 2032 source : AC6 7) chain B residue 871 type sequence F description BINDING SITE FOR RESIDUE KEE B 2032 source : AC6 8) chain B residue 934 type sequence D description BINDING SITE FOR RESIDUE KEE B 2032 source : AC6 9) chain B residue 974 type sequence G description BINDING SITE FOR RESIDUE KEE B 2032 source : AC6 10) chain B residue 840 type sequence D description BINDING SITE FOR RESIDUE ZN B 2033 source : AC7 11) chain B residue 842 type sequence H description BINDING SITE FOR RESIDUE ZN B 2033 source : AC7 12) chain B residue 934 type sequence D description BINDING SITE FOR RESIDUE ZN B 2033 source : AC7 13) chain B residue 667 type sequence C description BINDING SITE FOR RESIDUE ZN B 2034 source : AC8 14) chain B residue 669 type sequence C description BINDING SITE FOR RESIDUE ZN B 2034 source : AC8 15) chain B residue 675 type sequence H description BINDING SITE FOR RESIDUE ZN B 2034 source : AC8 16) chain B residue 751 type sequence C description BINDING SITE FOR RESIDUE ZN B 2034 source : AC8 17) chain B residue 838 type sequence D description BINDING SITE FOR RESIDUE NA B 2035 source : AC9 18) chain B residue 840 type sequence D description BINDING SITE FOR RESIDUE NA B 2035 source : AC9 19) chain B residue 842 type sequence H description BINDING SITE FOR RESIDUE NA B 2035 source : AC9 20) chain B residue 861 type sequence S description BINDING SITE FOR RESIDUE NA B 2035 source : AC9 21) chain B residue 862 type sequence L description BINDING SITE FOR RESIDUE NA B 2035 source : AC9 22) chain B residue 851 type sequence F description BINDING SITE FOR RESIDUE NA B 2036 source : BC1 23) chain B residue 854 type sequence D description BINDING SITE FOR RESIDUE NA B 2036 source : BC1 24) chain B residue 857 type sequence V description BINDING SITE FOR RESIDUE NA B 2036 source : BC1 25) chain B residue 888 type sequence F description BINDING SITE FOR RESIDUE NA B 2036 source : BC1 26) chain B residue 696 type sequence G description BINDING SITE FOR RESIDUE KEE D 2036 source : BC7 27) chain B residue 803 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 667 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 29) chain B residue 669 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 30) chain B residue 675 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 31) chain B residue 751 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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