eF-site ID 4cby-A PDB Code 4cby Chain A click to enlarge Title Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease Classification HYDROLASE Compound HISTONE DEACETYLASE 4 Source Homo sapiens (Human) (HDAC4_HUMAN) Sequence A:  TTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRLQET GLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPANRQK LDSKKLLGSLASVFVRLPCGGVGVDSDTIWNEVHSAGAAR LAVGCVVELVFKVATGELKNGFAVVRPPGHHAEESTPMGF CYFNSVAVAAKLLQQRLSVSKILIVDWDVHHGNGTQQAFY SDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNM AFTGGLDPPMGDAEYLAAFRTVVMPIASEFAPDVVLVSSG FDAVEGHPTPLGGYNLSARCFGYLTKQLMGLAGGRIVLAL EGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNAN AVRSMEKVMEIHSKYWRCLQ Description (1)  HISTONE DEACETYLASE 4 (E.C.3.5.1.98) Functional site 1) chain A residue 681 type sequence R description BINDING SITE FOR RESIDUE KEE A 2033 source : AC1 2) chain A residue 802 type sequence H description BINDING SITE FOR RESIDUE KEE A 2033 source : AC1 3) chain A residue 803 type sequence H description BINDING SITE FOR RESIDUE KEE A 2033 source : AC1 4) chain A residue 812 type sequence F description BINDING SITE FOR RESIDUE KEE A 2033 source : AC1 5) chain A residue 840 type sequence D description BINDING SITE FOR RESIDUE KEE A 2033 source : AC1 6) chain A residue 842 type sequence H description BINDING SITE FOR RESIDUE KEE A 2033 source : AC1 7) chain A residue 871 type sequence F description BINDING SITE FOR RESIDUE KEE A 2033 source : AC1 8) chain A residue 934 type sequence D description BINDING SITE FOR RESIDUE KEE A 2033 source : AC1 9) chain A residue 974 type sequence G description BINDING SITE FOR RESIDUE KEE A 2033 source : AC1 10) chain A residue 840 type sequence D description BINDING SITE FOR RESIDUE ZN A 2034 source : AC2 11) chain A residue 842 type sequence H description BINDING SITE FOR RESIDUE ZN A 2034 source : AC2 12) chain A residue 934 type sequence D description BINDING SITE FOR RESIDUE ZN A 2034 source : AC2 13) chain A residue 667 type sequence C description BINDING SITE FOR RESIDUE ZN A 2035 source : AC3 14) chain A residue 669 type sequence C description BINDING SITE FOR RESIDUE ZN A 2035 source : AC3 15) chain A residue 675 type sequence H description BINDING SITE FOR RESIDUE ZN A 2035 source : AC3 16) chain A residue 751 type sequence C description BINDING SITE FOR RESIDUE ZN A 2035 source : AC3 17) chain A residue 838 type sequence D description BINDING SITE FOR RESIDUE NA A 2036 source : AC4 18) chain A residue 840 type sequence D description BINDING SITE FOR RESIDUE NA A 2036 source : AC4 19) chain A residue 842 type sequence H description BINDING SITE FOR RESIDUE NA A 2036 source : AC4 20) chain A residue 861 type sequence S description BINDING SITE FOR RESIDUE NA A 2036 source : AC4 21) chain A residue 862 type sequence L description BINDING SITE FOR RESIDUE NA A 2036 source : AC4 22) chain A residue 851 type sequence F description BINDING SITE FOR RESIDUE NA A 2037 source : AC5 23) chain A residue 854 type sequence D description BINDING SITE FOR RESIDUE NA A 2037 source : AC5 24) chain A residue 857 type sequence V description BINDING SITE FOR RESIDUE NA A 2037 source : AC5 25) chain A residue 888 type sequence F description BINDING SITE FOR RESIDUE NA A 2037 source : AC5 26) chain A residue 803 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 27) chain A residue 667 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 669 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 675 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 751 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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