eF-site ID 4cbt-C PDB Code 4cbt Chain C click to enlarge Title Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease Classification HYDROLASE Compound HISTONE DEACETYLASE 4 Source Homo sapiens (Human) (HDAC4_HUMAN) Sequence C:  GSTKPRFTTGLVYDTLMLKHQCTCSHPEHAGRIQSIWSRL QETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLT IWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVRPP GHHAEESTPMGFCYFNSVAVAAKLLQQRLSKILIVDWDVH HGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGT GPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPIASEF APDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMG LAGGRIVLALEGGHDLTAICDASEACVSALLGNEKVLQQR PNANAVRSMEKVMEIHSKYWRCLQRH Description (1)  HISTONE DEACETYLASE 4 (E.C.3.5.1.98) Functional site 1) chain C residue 681 type sequence R description BINDING SITE FOR RESIDUE 9F4 C 2035 source : AC7 2) chain C residue 726 type sequence N description BINDING SITE FOR RESIDUE 9F4 C 2035 source : AC7 3) chain C residue 802 type sequence H description BINDING SITE FOR RESIDUE 9F4 C 2035 source : AC7 4) chain C residue 803 type sequence H description BINDING SITE FOR RESIDUE 9F4 C 2035 source : AC7 5) chain C residue 811 type sequence G description BINDING SITE FOR RESIDUE 9F4 C 2035 source : AC7 6) chain C residue 812 type sequence F description BINDING SITE FOR RESIDUE 9F4 C 2035 source : AC7 7) chain C residue 840 type sequence D description BINDING SITE FOR RESIDUE 9F4 C 2035 source : AC7 8) chain C residue 842 type sequence H description BINDING SITE FOR RESIDUE 9F4 C 2035 source : AC7 9) chain C residue 871 type sequence F description BINDING SITE FOR RESIDUE 9F4 C 2035 source : AC7 10) chain C residue 934 type sequence D description BINDING SITE FOR RESIDUE 9F4 C 2035 source : AC7 11) chain C residue 974 type sequence G description BINDING SITE FOR RESIDUE 9F4 C 2035 source : AC7 12) chain C residue 840 type sequence D description BINDING SITE FOR RESIDUE ZN C 2036 source : AC8 13) chain C residue 842 type sequence H description BINDING SITE FOR RESIDUE ZN C 2036 source : AC8 14) chain C residue 934 type sequence D description BINDING SITE FOR RESIDUE ZN C 2036 source : AC8 15) chain C residue 667 type sequence C description BINDING SITE FOR RESIDUE ZN C 2037 source : AC9 16) chain C residue 669 type sequence C description BINDING SITE FOR RESIDUE ZN C 2037 source : AC9 17) chain C residue 675 type sequence H description BINDING SITE FOR RESIDUE ZN C 2037 source : AC9 18) chain C residue 803 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 19) chain C residue 669 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 20) chain C residue 675 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 21) chain C residue 667 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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