eF-site ID 4cbt-B PDB Code 4cbt Chain B click to enlarge Title Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease Classification HYDROLASE Compound HISTONE DEACETYLASE 4 Source Homo sapiens (Human) (HDAC4_HUMAN) Sequence B:  KPRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSR LQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPS DTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVR PPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVD WDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPD EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPI ASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK QLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNDPL PEKVLQQRPNANAVRSMEKVMEIHSKYWRCLQ Description (1)  HISTONE DEACETYLASE 4 (E.C.3.5.1.98) Functional site 1) chain B residue 681 type sequence R description BINDING SITE FOR RESIDUE 9F4 B 2034 source : AC4 2) chain B residue 726 type sequence N description BINDING SITE FOR RESIDUE 9F4 B 2034 source : AC4 3) chain B residue 802 type sequence H description BINDING SITE FOR RESIDUE 9F4 B 2034 source : AC4 4) chain B residue 803 type sequence H description BINDING SITE FOR RESIDUE 9F4 B 2034 source : AC4 5) chain B residue 812 type sequence F description BINDING SITE FOR RESIDUE 9F4 B 2034 source : AC4 6) chain B residue 840 type sequence D description BINDING SITE FOR RESIDUE 9F4 B 2034 source : AC4 7) chain B residue 842 type sequence H description BINDING SITE FOR RESIDUE 9F4 B 2034 source : AC4 8) chain B residue 871 type sequence F description BINDING SITE FOR RESIDUE 9F4 B 2034 source : AC4 9) chain B residue 934 type sequence D description BINDING SITE FOR RESIDUE 9F4 B 2034 source : AC4 10) chain B residue 942 type sequence P description BINDING SITE FOR RESIDUE 9F4 B 2034 source : AC4 11) chain B residue 975 type sequence G description BINDING SITE FOR RESIDUE 9F4 B 2034 source : AC4 12) chain B residue 840 type sequence D description BINDING SITE FOR RESIDUE ZN B 2035 source : AC5 13) chain B residue 842 type sequence H description BINDING SITE FOR RESIDUE ZN B 2035 source : AC5 14) chain B residue 934 type sequence D description BINDING SITE FOR RESIDUE ZN B 2035 source : AC5 15) chain B residue 667 type sequence C description BINDING SITE FOR RESIDUE ZN B 2036 source : AC6 16) chain B residue 669 type sequence C description BINDING SITE FOR RESIDUE ZN B 2036 source : AC6 17) chain B residue 675 type sequence H description BINDING SITE FOR RESIDUE ZN B 2036 source : AC6 18) chain B residue 803 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 667 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 669 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 675 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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