eF-site ID 4cbt-A PDB Code 4cbt Chain A click to enlarge Title Design, synthesis, and biological evaluation of potent and selective Class IIa HDAC inhibitors as a potential therapy for Huntington's disease Classification HYDROLASE Compound HISTONE DEACETYLASE 4 Source Homo sapiens (Human) (HDAC4_HUMAN) Sequence A:  PRFTTGLVYDTLMLKHQCTCGSSSSHPEHAGRIQSIWSRL QETGLRGKCECIRGRKATLEELQTVHSEAHTLLYGTNPLS DTIWNEVHSAGAARLAVGCVVELVFKVATGELKNGFAVVR PPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVD WDVHHGNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPD EVGTGPGVGFNVNMAFTGGLDPPMGDAEYLAAFRTVVMPI ASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTK QLMGLAGGRIVLALEGGHDLTAICDASEACVSALLGNELL QQRPNANAVRSMEKVMEIHSKYWRCLQRH Description (1)  HISTONE DEACETYLASE 4 (E.C.3.5.1.98) Functional site 1) chain A residue 726 type sequence N description BINDING SITE FOR RESIDUE 9F4 A 2035 source : AC1 2) chain A residue 728 type sequence L description BINDING SITE FOR RESIDUE 9F4 A 2035 source : AC1 3) chain A residue 765 type sequence V description BINDING SITE FOR RESIDUE 9F4 A 2035 source : AC1 4) chain A residue 802 type sequence H description BINDING SITE FOR RESIDUE 9F4 A 2035 source : AC1 5) chain A residue 803 type sequence H description BINDING SITE FOR RESIDUE 9F4 A 2035 source : AC1 6) chain A residue 812 type sequence F description BINDING SITE FOR RESIDUE 9F4 A 2035 source : AC1 7) chain A residue 840 type sequence D description BINDING SITE FOR RESIDUE 9F4 A 2035 source : AC1 8) chain A residue 842 type sequence H description BINDING SITE FOR RESIDUE 9F4 A 2035 source : AC1 9) chain A residue 871 type sequence F description BINDING SITE FOR RESIDUE 9F4 A 2035 source : AC1 10) chain A residue 934 type sequence D description BINDING SITE FOR RESIDUE 9F4 A 2035 source : AC1 11) chain A residue 943 type sequence L description BINDING SITE FOR RESIDUE 9F4 A 2035 source : AC1 12) chain A residue 974 type sequence G description BINDING SITE FOR RESIDUE 9F4 A 2035 source : AC1 13) chain A residue 840 type sequence D description BINDING SITE FOR RESIDUE ZN A 2036 source : AC2 14) chain A residue 842 type sequence H description BINDING SITE FOR RESIDUE ZN A 2036 source : AC2 15) chain A residue 934 type sequence D description BINDING SITE FOR RESIDUE ZN A 2036 source : AC2 16) chain A residue 667 type sequence C description BINDING SITE FOR RESIDUE ZN A 2037 source : AC3 17) chain A residue 669 type sequence C description BINDING SITE FOR RESIDUE ZN A 2037 source : AC3 18) chain A residue 675 type sequence H description BINDING SITE FOR RESIDUE ZN A 2037 source : AC3 19) chain A residue 803 type ACT_SITE sequence H description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 667 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 669 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 22) chain A residue 675 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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